Podcasts · Health & Fitness · Education

The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey

300 episodes

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

More about the show

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

Episodes page 1 of 6

  1. The Easiest Treatment That Made Me 15 Years Younger : 1563

    · 43 min · Episode 1563

    Explore House of Evolution: https://daveasprey.com/house-of-evolution/ Host Dave Asprey sits down with Dr. Tim Cook, a physician and longevity medicine expert who previously served as personal physician to two…

  2. How To Reverse Your Age For $5 Day (Budget Biohacking) : 1562

    · 24 min · Episode 1562

    I have spent $2.5 million on this body, and Bryan Johnson spends about $5,400 a day on his. But does it need to be that expensive to biohack? So I gave myself a challenge: build a complete anti-aging protocol for…

  3. Avoid THESE "Healthy" Superfoods : 1561

    · 1 h 16 min · Episode 1561

    We just had to bring this one back for you. Today, we’re digging once again into specifics about food that you haven’t heard on the show before. This one may very well influence you to rethink your “healthy” diet and…

  4. How to Trigger Flow States From The 5 Brain Chemicals You Need : 1559

    · 56 min · Episode 1559

    The Neuroscience of Flow, Peak Performance, Psychedelics, Trauma, Intuition & Consciousness with Steven Kotler Host Dave Asprey sits down with Steven Kotler, New York Times bestselling author and leading researcher in…

  5. The 6-Minute Morning Routine That Can Change Your Life : 1558

    · 49 min · Episode 1558

    The Miracle Morning, Visualization, Affirmations, Meditation, Morning Routines, Productivity & the Psychology of Success with Hal Elrod Host Dave Asprey sits down with Hal Elrod, bestselling author of The Miracle…

  6. 400mg Before Bed Improves Deep Sleep by 1700% : 1557

    · 13 min · Episode 1557

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ I slept 8 hours a night and got 5 minutes of deep sleep,…

  7. John Gray: Why Men Stop Wanting Their Wives : 1556

    · 1 h 45 min · Episode 1556

    The king is back! You probably recognize his name as the author of the famous book, Men Are From Mars, Women Are From Venus. But what's especially exciting is how John has evolved his insights to address the changing…

  8. Sleep Expert: 80% of Sleep Problems Come From THIS : 1555

    · 40 min · Episode 1555

    Sleep Anxiety, Insomnia, Circadian Rhythms, Chronotypes, Sleep Trackers & How to Sleep Better with Dr. Michael Breus Host Dave Asprey sits down with Dr. Michael Breus, clinical psychologist, sleep specialist, and…

  9. The Science Behind Joint and Cartilidge Repair : 1554

    · 49 min · Episode 1554

    Explore Calroy's vascular health and joint support supplements, including Arterosil, Vascanox, and Cartigenix, at https://calroy.com/dave Cartilage Regeneration, Joint Pain, Nitric Oxide, Blood Flow, Muscle Strength &…

  10. Your Brain Has a Focus Switch (Here's How to Turn It On) : 1553

    · 19 min · Episode 1553

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ This video reveals that the brain has a documented…

  11. Infections & Cancer, Finasteride Side Effects, Blueberry Benefits, Vitamin D & Fertility, and CoQ10 : 1552

    · 11 min · Episode 1552

    Infections Were Linked to About 1 in 8 Cancer Cases Worldwide A new global analysis estimates that infections were responsible for roughly 2.3 million new cancer cases in 2024, about 12% of all cancers worldwide. H.…

  12. How to Unlock Psychic Abilities to Know When You’ll Die : 1551

    · 1 h 04 min · Episode 1551

    Get a free digital and audiobook copy of Angelic Attendants at https://askjulieryan.com/request-ebook/ Psychic Abilities, Medical Intuition, Energy Healing, Remote Viewing & What Happens When We Die with Julie Ryan…

  13. How to Live Healthier Without Obsessing Over Health : 1550

    · 52 min · Episode 1550

    Grab 20% off KORA Organics with code HUMAN20 at https://koraorganics.pxf.io/9VdD0E. Clean Living, Stress Reduction, Sleep, Skincare & Simple Wellness Habits with Miranda Kerr Host Dave Asprey sits down with Miranda…

  14. It's Boring, But It Slashed ALL My Visceral Fat In My 50s : 1549

    · 19 min · Episode 1549

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ I'm in the best shape of my life, and it has nothing to do…

  15. Vagus Nerve Memory, Cat Cancer Genes, Inherited Intelligence, Mulberry Microbes, and Vitamin D : 1548

    · 11 min · Episode 1548

    Vagus Nerve Stimulation Improves Cognitive Scores in a Small Trial In a 24-week trial involving people with mild cognitive impairment, participants assigned to electrical stimulation at vagus-innervated parts of the…

  16. Dave’s Anti-Aging Skincare Routine: Exosomes, Methylene Blue & NAD+ : 1547

    · 47 min · Episode 1547

    Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode. Skin Longevity, Cellular Repair, Red Light Therapy & the Biology of Younger Skin with Young…

  17. The Silent Fatty Liver Epidemic: Why Thin, Sober People Are Still at Risk : 1546

    · 57 min · Episode 1546

    Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode. Host Dave Asprey sits down with Siggi Clavien, Founder and CEO of The Liver Clinic and…

  18. Every Way to Melt Visceral Fat FAST In 14 Minutes : 1545

    · 14 min · Episode 1545

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies:…

  19. Ozempic Hair, GLP-1 Kids, Gut-Brain Anxiety, Food Additives, Taurine, and more : 1544

    · 15 min · Episode 1544

    Novo Nordisk Eyes Hair-Loss Market in Consumer-Health Expansion Novo Nordisk, the company behind Ozempic and Wegovy, is exploring hair loss as one of several possible areas for future expansion, alongside menopause…

  20. The Best Singular Hack To Change EVERYTHING About Your Life : 1543

    · 1 h 14 min · Episode 1543

    Back again with one of the best episodes we've done on the channel. So good that we had to play it once more for you! Today you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness…

  21. 15g Every Morning for Anti-Aging Mitochondria : 1541

    · 59 min · Episode 1541

    Catharine Arnston on Spirulina, Chlorella, Mitochondria, Detox, Brain Energy, and Longevity Visit https://energybits.com/ and use code HUMANUPGRADE for 20% off. Could one of the oldest foods on Earth also be one of…

  22. I Wasted 10 Years Stuck With Brain Fog Until I Learned This : 1540

    · 21 min · Episode 1540

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies:…

  23. Teal Swan - Beyond the Veil of Ego, AI & Wisdom : 1539

    · 1 h 03 min · Episode 1539

    Back with another all-time classic. Teal's is one of those episodes I keep going back to because it was just that good. Now more than ever, we need to ask ourselves: what is the role of Ego? Do we need to worry about…

  24. How to Hack Your Smell for Memory and Longevity WHILE YOU SLEEEP! : 1538

    · 54 min · Episode 1538

    Dr. Michael Leon on Smell Training, Memory, Sleep, Alzheimer’s Risk, and Brain Longevity Your sense of smell may reveal more about your brain health than you realize, and stimulating it while you sleep may improve…

  25. Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537

    · 56 min · Episode 1537

    **Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation!** At 53, Josh Duhamel says he feels better than he did in his 30s. Host Dave Asprey sits down with actor and Gatlan Health founder…

  26. The Peptide Secrets to a Youthful Face : 1536

    · 56 min · Episode 1536

    Carolina Reis de Oliveira on Reversing Skin Age, Menopause, GLP-1 Skin, and the Science of Senescent Cells Your skin is likely biologically older than you are, but new research suggests some of that aging may be…

  27. What 36 Hours Without Sugar Does to Your Body : 1535

    · 12 min · Episode 1535

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies:…

  28. New Seafood Superfood, Apple Watch Health Age, Botanical Drugs, Cannabis IQ, and Blueberries : 1534

    · 9:48 · Episode 1534

    Sea Squirt Plasmalogens Show Brain And Aging Benefits In Old Mice Aged mice given purified plasmalogen supplements showed better memory performance, healthier synaptic structure, lower neuroinflammation, and increased…

  29. Everything You Need To Know About Your Poop | Gut Surgeon Explains : 1533

    · 1 h 09 min · Episode 1533

    Dr. Karan Rajan on Fiber Fermentation, Sodium Myths, and What Your Poop Reveals About Disease Risk Your poop is more predictive than almost any other health signal, and you are flushing that data away every single day…

  30. If I Had To Lose 50 Pounds FAST, I’d Do THIS : 1532

    · 10 min · Episode 1532

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies:…

  31. Raw Garlic, Egg Yolks, Heat Strokes, and Melatonin : 1531

    · 7:48 · Episode 1531

    Raw Garlic "Ultimate Biohack" Trend Faces Scientific Scrutiny Raw garlic has gone viral as a morning ritual, with fans crushing a clove, mixing it with honey, and crediting it with everything from lower cholesterol…

  32. Jenny McCarthy | The 3 Questions You’re NEVER Supposed to Ask : 1530

    · 1 h 58 min · Episode 1530

    Jenny McCarthy on Reversing Autism, Healing Mold Toxicity, and the Biohacking Protocol Big Pharma Doesn't Want You to Know Back with another long one! Autism, mold poisoning, and cognitive decline share more root…

  33. 3 Longevity Drugs I QUIT (And the 4 I Take Instead) : 1529

    · 36 min · Episode 1529

    The 3 "Longevity Drugs" That Fail the Data, and 4 Repurposed Ones Worth Considering Back with another solo episode, this one on Big Pharma! Metformin, rapamycin, and statins are three of the most trusted names in…

  34. 7 Brain Compounds I Take For Superhuman Focus : 1528

    · 9:43 · Episode 1528

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies:…

  35. Change Your Morning, Change Your Life! Hal Elrod : 1527

    · 1 h 14 min · Episode 1527

    Starting your weekend off right, with the king of mindset. We had to replay this one because it's too goo not to! Meet a man who makes miracles happen. Today, I’m joined in the studio by Hal Elrod, author of the…

  36. Learn THIS And You’ll Become Impossible To Trigger : 1526

    · 1 h 02 min · Episode 1526

    Jonny Miller on Nervous System Mastery, Grief, and Why High Performers Can't Afford to Stay Stuck in Their Heads Your nervous system is running every decision, relationship, and reaction in your life, and you won't…

  37. Jim Kwik: If You're Using AI Like This, You're Killing Your Brain : 1525

    · 1 h 02 min · Episode 1525

    Jim Kwik on Memory, AI, and Why Natural Intelligence Beats Artificial Intelligence Your brain is quietly outsourcing itself to AI, and you won't notice until it's gone. This episode gives you the exact framework to…

  38. The Most Important Longevity Molecule I've Ever Found : 1524

    · 15 min · Episode 1524

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies:…

  39. The Scientist Monk: Gurudev Sri Sri Ravi Shankar : 1523

    · 36 min · Episode 1523

    This Friday, I had to play back an all-time favorite. I was honored and grateful to bring you a conversation that I recorded in person with Gurudev Sri Sri Ravi Shankar at the Art of Living Center in Los Angeles.…

  40. The Wild New Theory of Cancer (It's GOOD For You?) : 1522

    · 1 h 03 min · Episode 1522

    Quantum Scientist Patrick Coles Reveals How Tumors Protect Your Mitochondria From Toxic Overload Cancer might not be the enemy your doctor says it is. What if tumors are actually your body's emergency detox system,…

  41. Scream Cream and Weekly Injections (Double Episode) | Gabby Reece : 1521

    · 2 h 47 min · Episode 1521

    Dave Asprey and Gabby Reece Talk Testosterone Therapy, Scream Cream, Autism as a Superpower, Cancer Protocols, and Surviving Fame in This Double Interview Episode Mega-Episode time! Your hormones might be causing…

  42. It's Weird, But It Turns On Your Anti-Aging Switch : 1520

    · 15 min · Episode 1520

    Save Up To $600: SUNLIGHTEN.COM/DAVE Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Most people see…

  43. Depressing Fruit, Vitamin (C)ancer, Sheep Wool, Oral GLP-1s, Endless Exercise, and more : 1519

    · 11 min · Episode 1519

    PhenoNet Cleared By FDA To Begin Phase 3 Trial Of Inhaled Alzheimer's Drug PhenoNet has received FDA clearance to begin a Phase 3 trial of PHENOGENE-1A, an inhaled formulation of cromolyn sodium, an asthma drug with…

  44. Dave Solo Pod: The Original Smart Drug Masterclass : 1518

    · 41 min · Episode 1518

    Piracetam, Racetams & Nootropics: Dave Asprey on the Original Smart Drug, Brain Optimization and How to Biohack Memory, Focus and Cognitive Decline We're excited to bring you another Dave solo education masterclass,…

  45. Steven Greer | UAP’s and Remote Viewing Techniques for Non-Human Life : 1517

    · 1 h 11 min · Episode 1517

    UFOs, UAPs, Non-Human Contact & Zero-Point Energy: Dr. Steven Greer on Government Disclosure, Consciousness and the Truth About Extraterrestrial Intelligence Get ready to have your entire understanding of reality…

  46. 300mg Improves Appearance of Wrinkles In 7 Days (Study) : 1516

    · 14 min · Episode 1516

    This video reveals how your skin uses glutathione to defend itself, how Dr. Nayan Patel solved its delivery problem, and why his topical antioxidant serum was clinically shown to improve the appearance of fine lines,…

  47. Longevity Music, Anti-Aging Nasal Spray, How To Look 20, and more... : 1515

    · 11 min · Episode 1515

    Subtitle: A Nasal Spray Longevity Screen, Why Less Protein May Age You Better, Cadaver Skin Injectables, Art's Effect on Biological Age, and Which Anti-Aging Interventions Actually Move the Needle Nasal Spray…

  48. Here's How You Can Have a 3-hour Orgasm (real!) : 1514

    · 1 h 01 min · Episode 1514

    The Orgasm Code: How Pleasure Rewires Your Nervous System for Longevity & Healing | Regena Thomashauer (Mama Gena) Most people think pleasure is a distraction from performance. This episode proves the opposite: your…

  49. I Take 150 Pills a Day (But This One Is My Workhorse) | Resbiotic : 1513

    · 1 h 13 min · Episode 1513

    The Gut-Lung Axis: The Missing Link in Chronic Inflammation & Aging | Dr. Vivek Lal Your lungs have a microbiome, and almost no one is talking about it. This episode reveals the hidden pathway behind asthma, chronic…

  50. I Wish I Knew This Anti-Aging Hack Sooner : 1512

    · 14 min · Episode 1512

    There is one molecule your body already makes that helps protect your cells from aging, but your production of it drops as you get older. In this video, I explain why glutathione is known as the body’s master…

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