Podcasts · Health & Fitness

Extend Podcast with Darshan Shah, MD

Darshan Shah, MD

212 episodes

Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan.

More about the show

Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results.

That's why this podcast is all about cutting through the noise on how to turn back the aging clock. I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health.

Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.

Episodes page 1 of 5

  1. 211. Emma Heming Willis and Dr. Nicole Beurkens: Why Women Face a Higher Alzheimer's Risk—Menopause, Brain Fog & Prevention

    · 1 h 10 min

    What if the brain fog, forgetfulness, poor sleep, and mood changes so many women experience in midlife aren't just signs of getting older—but signals that their brains need more support? Women account for nearly…

  2. 210. Dr. Rena Malik: Why Erectile Dysfunction Could Be an Early Warning Sign of Heart Disease

    · 1 h 07 min

    What if problems in the bedroom were actually an early warning sign of something much bigger happening in your body? Most people think of sexual health as separate from their overall health. But erectile dysfunction,…

  3. 209. Dr. David Barzilai: Can We Reverse Aging? Harvard's Latest Longevity Science Explained

    · 1 h 05 min

    What if aging isn't just something that happens to us—but a biological process we can actually influence? For decades, medicine has focused on treating diseases after they develop. But a growing field called…

  4. 208. Dr. Thais Aliabadi: PCOS & Endometriosis—The Symptoms Women Should Never Ignore

    · 1 h 07 min

    What if the painful periods, irregular cycles, unexplained weight gain, acne, and fertility struggles so many women experience aren't something they should simply learn to live with? Too often, women are told their…

  5. 207. Dr. Jason Wersland: The Science of Recovery—Pain, HRV, Sleep & Your Nervous System

    · 55 min

    We spend so much time thinking about exercise, nutrition, and performance—but I believe recovery may be one of the most overlooked pieces of longevity. In this episode, I'm joined by Dr. Jason Wersland, chiropractor…

  6. 206. Dr. Pamela Smith: The Truth About Hormone Replacement Therapy—HRT, Menopause & Cancer Risk

    · 54 min

    Hormones influence far more than reproductive health. They affect your sleep, mood, metabolism, muscle, bone health, brain function, stress response, and how you age—yet hormone health is still often reduced to a…

  7. 205. Rajeev Kapur: How AI Is Transforming Healthcare

    · 1 h 03 min

    What if AI could change the way we understand, manage, and optimize our health? In today's episode, my guest is Rajeev Kapur, a leading AI advisor, educator, speaker, and author who helps non technical leaders…

  8. 204. Dr. Cassie Smith: Fix Your Gut, Fix Your Hormones, Fix Your Health

    · 56 min

    What if your gut health is the missing piece behing your hormones, energy, metabolism, and how you feel every day? Today, I sit down with Dr. Cassie Smith, a double board-certiied endocrinologist and internal medicine…

  9. 203. Sat Randhawa: Can You Train Your Brain? QEEG & Neurofeedback

    · 1 h 11 min

    What if we stopped guessing about the brain and started measuring it? In today's episode, my guest is Sat Randhawa of One-Hype Wellness, where he and his team are focused on using brain mapping and neurotechnology to…

  10. 202. Dr. Colleen Cutcliffe: The Fiber-Gut Connection: How to Improve Your Microbiome, Blood Sugar & Cholesterol

    · 53 min

    Most people know they should eat more fiber. But what we're learning about fiber, gut health, and the microbiome goes far beyond digestion. Your gut contains trillions of microbes that depend on what you eat—and…

  11. 201: Joey Munoz: The Truth About Nutrition, Protein, Weight Loss & Muscle

    · 1 h 23 min

    What if the biggest mistake you're making with your health isn't what you're eating - but the way you're thinking about nutrition in the first place? In this episode, I'm joined by Dr. Joey Munoz, a PhD in Nutrition…

  12. 200. Dr. Will Cole: How to Heal Your Cells—Mitochondria, Peptides & the Science of Aging

    · 1 h 10 min

    What if the fatigue, brain fog, low energy, and other symptoms we associate with getting older actually begin much deeper—at the level of our cells? I've followed Dr. Will Cole's work for years, and his approach to…

  13. 199. Dr. Jeffrey Wiegers: Stem Cells Explained—What They Can Do Now & What's Coming Next

    · 1 h 10 min

    What if medicine could do more than manage disease—and actually help the body repair itself? Regenerative medicine is moving quickly, but the world of stem cells, PRP, exosomes, and cellular therapies can be…

  14. 198. Dr. Bryce Appelbaum: Your Eyes Are Connected to Everything—Focus, Balance, Brain Health & Aging

    · 59 min

    What if your eyesight is 20/20—but your vision still isn't working the way it should? Dr. Bryce Appelbaum specializes in functional vision and the connection between the eyes and the brain. In this conversation, he…

  15. 197. Ben Greenfield: When Biohacking Goes Too Far—What Actually Matters for Longevity

    · 58 min

    What happens when optimizing your health starts taking over your life? Ben Greenfield has spent decades at the forefront of biohacking, fitness, human performance, and longevity—testing the technologies, tracking the…

  16. 196: Dr. Jill Carnahan: Is Mold Making You Sick? Hidden Toxins, Symptoms & Detox

    · 54 min

    What if the fatigue, brain fog, inflammation, or unexplained symptoms you're experiencing aren't starting inside your body—but in the environment around you? Dr. Jill Carnahan knows this story from both sides of the…

  17. 195: Jeff Byers: Inside the Supplement Industry: The 4 Supplements That Actually Matter

    · 1 h 20 min

    Walk into any supplement aisle—or scroll through social media—and you'll find thousands of products promising better energy, performance, brain health, and longevity. But which supplements actually work? And how do you…

  18. 194: Dr. Mark Hyman: Why You're Still Sick—Finding the Root Cause With Functional Medicine

    · 59 min

    What if the reason you're still sick isn't because there's no answer—but because no one has looked deeply enough for the root cause? My guest, Dr. Mark Hyman, is one of the world's leading voices in functional…

  19. 193: Dr. Sasha Hamdani: ADHD, Anxiety and How to Regulate your Emotions

    · 51 min

    What if ADHD isn't just an attention problem—but also a problem of emotional regulation? My guest, Dr. Sasha Hamdani, is a board-certified psychiatrist, ADHD specialist, author, and someone who has lived with ADHD…

  20. 192: Dr. Perlmutter: How to Protect Your Brain From Alzheimer's & Cognitive Decline

    · 1 h 09 min

    What if your risk of Alzheimer's isn't predetermined by your genes—but influenced by the metabolic health of your brain? My guest, Dr. David Perlmutter, is a board-certified neurologist, six-time New York Times…

  21. 191: Kiran Krishnan: How to Rebuild Your Gut Microbiome & Reduce Inflammation

    · 1 h 12 min

    What if the biggest mistake we're making with gut health is treating the microbiome like a list of bacteria instead of a living ecosystem? Your gut is home to trillions of microorganisms that influence inflammation,…

  22. 190. Dr. William Harris: 90% of Americans Are Low in This Critical Longevity Nutrient

    · 58 min

    What if one of the most important markers for your heart, brain, and longevity is something most people have never measured? AND roughly 90% of Americans aren't in the optimal range for? In this episode, I sit down…

  23. 189. Dr. Florence Comite: The 5 Biomarkers That Predict How You'll Age

    · 36 min

    What if aging isn't something you simply accept - but something you can measure, predict, and even reverse? Most of us are told our lab work is "normal," yet chronic disease often develops silently for years before…

  24. 188. James Beshara: How to Find Productivity Without the Hustle

    · 1 h 07 min

    We're living in a culture that celebrates being busy. More coffee. More hours. More hustle. But what if those things are actually making you less productive? The truth is, many high performers are stuck in a cycle of…

  25. 187. Dr. Izabella Wentz: 30+ Root Causes Behind An IBS Diagnosis

    · 59 min · Episode 187

    Hashimotos isn't just a thyroid disease-it may actually begin in the gut. If you've been told your thyroid labs are "normal" but you still struggle with fatigue, bloating, constipation, IBS, or autoimmune symptoms,…

  26. 186. Raj Sisodia: The Inner Work Behind Better Leadership

    · 1 h 09 min

    A leader's unresolved pain rarely stays contained within that leader. It can show up as control, aggression, emotional distance, relentless pressure, or a workplace where people are treated as resources rather than…

  27. 185. Dr. Neha Sangwan: The 5 Questions That Predict a Health Crisis Before It Happens

    · 53 min

    I have operated on patients whose bodies had been sending them warning signals for years before a crisis ever put them in front of me. Stress alone causes or worsens more than 80 percent of the illness I see, and most…

  28. 184. Dr. Sahil Chopra & Sagar Chopra: Why Your Sleep Apnea Machine Might Be Lying to You

    · 1 h 06 min · Episode 184

    Millions of people wear a CPAP machine every night, the standard breathing device prescribed for sleep apnea. They trust the number on the screen to tell them their sleep apnea is under control. I've had patients tell…

  29. 183. Rachel Lambert & Angie Noack: Why 70% Of ADHD Diagnoses Are Wrong

    · 54 min

    For most people, an ADHD diagnosis, an anxiety diagnosis, or a depression diagnosis is made entirely from a symptom checklist. No one looks at the brain producing those symptoms. In this episode, I sit down with…

  30. 182. Michael Easter: The Hidden Health Cost of Modern Comfort

    · 58 min

    A lot of people do not need to be convinced that the stairs are better than the escalator, walking is better than sitting all day, and reaching for the phone every quiet second is probably not helping their focus. The…

  31. 181. Dr. Taz: The Hormone Conversation Women Should Have Before Birth Control, IVF, or HRT

    · 50 min

    For many women, the hormone conversation starts only when something becomes hard to ignore. Painful periods. Irregular cycles. Acne. Hair loss. Fertility struggles. Perimenopause symptoms. Too often, the answer is a…

  32. 180. Dr. John Kim: The Hidden Stressors Keeping Your Body in Defense Mode

    · 57 min

    When labs look normal, it is easy to assume the body is fine or that the biggest risks have been ruled out. Dr. John Kim's story challenges that belief. At 33, after a normal lipid panel and without the classic heart…

  33. 179. Dr. Scott McMahon: The Hidden Trigger Behind Your Unexplained Symptoms

    · 46 min · Episode 179

    Most people assume that once they leave a mold-exposed building, their body should recover. But I see this all the time in my clinic, the mold exposure ends, and the symptoms don't. In this episode of Extend, I sit…

  34. 178. Dr. Matt Kaeberlein: The Science, Risk, and Hype Behind Today's Longevity Trends

    · 1 h 14 min

    If you care about longevity, you have probably seen the same pattern over and over again. A new peptide, supplement, biological age test, off-label drug, or protocol starts gaining attention, and suddenly it sounds…

  35. 177. Dr. Jila Senemar: The Hormone Conversation Women Should Have Before Menopause

    · 42 min

    A lot of women are taught to think about hormones only when something becomes impossible to ignore. Painful periods. Birth control decisions. Fertility anxiety. Postpartum changes. Perimenopause symptoms. Menopause.…

  36. 176. Dr. Labib Ghulmiyyah: What Fertility Can Reveal About Your Long-Term Health

    · 57 min

    When a couple is trying to get pregnant and it is not happening, the conversation can become very intense very quickly. Suddenly, you are hearing about IVF, egg freezing, AMH, sperm count, hormones, age, cost, and…

  37. 175. Justin Roethlingshoefer: Why Your Body Needs More Than "Healthy Habits" To Heal

    · 53 min

    Your body is constantly repairing, renewing, and rebuilding itself. Hundreds of millions of cells are replaced every few months, which sounds incredible until you ask the question most people skip: if the body is…

  38. 174. Dr. Dave Rabin: Why Being Human Feels Harder Than It Should in 2026

    · 1 h 01 min

    A lot of people are trying to do the right things. They are learning more, tracking their health, working on their stress, trying to be more present, and using the tools they have been told should help. But if the…

  39. 173. Brian Le Gette: The Hidden Reason Your Body Struggles To Heal

    · 1 h 00 min

    When your body feels wired, depleted, foggy, inflamed, or slow to recover, the usual instinct is to add something else. Another supplement. Another device. Another protocol. But the body does not respond to tools just…

  40. 172. Dr. William Von Hippel: The Connection-Autonomy Paradox: Why More Freedom Can Make Us Feel More Alone

    · 51 min

    Modern life tells us that more freedom should make us happier. More independence, more control, more convenience, more space to do life on our own terms. But what if the thing we keep chasing is also the thing quietly…

  41. 171. Dr. Kristen Holmes: The Sleep Debt Problem Affecting Your Brain, Mood, and Relationships

    · 59 min

    Sleep debt is usually treated like a personal problem. You sleep less, feel tired, and try to catch up later. But Dr. Kristen Holmes explains why that belief is too small. When your body is missing the sleep it…

  42. 170. Dr. Sonya Jensen: The Hormone-Trauma Connection: Why Midlife Symptoms Are Not Just Physical

    · 57 min

    Hormone symptoms are usually treated like a problem with levels. Progesterone is low. Estrogen is shifting. Cortisol is high. Testosterone is dropping. So the conversation often becomes about what to replace, what to…

  43. 169. Natalie Lefevre: How to Find the Toxins Blocking Your Body's Ability to Heal

    · 47 min

    You can do the supplements, the IVs, the sauna, the clean eating, and the wellness routine, but if your body is still being exposed to toxins every day, you may be cleaning up a mess while the tap is still running.…

  44. 168. Peter Crone: Why You Can't Access True Vitality Until You Free Your Mind

    · 56 min

    When we talk about health, longevity, and performance, the conversation often starts with the body. We look at biomarkers, sleep, nutrition, exercise, recovery, and protocols, hoping that if we get enough of the…

  45. 167. Dr. Amie Hornaman: The Thyropause Problem: Why So Many Women Feel Off in Midlife Despite "Normal" Labs

    · 56 min · Episode 167

    Have you entered midlife and started gaining weight, feeling exhausted, waking up foggy, losing motivation, or noticing your mood shift while your labs keep coming back "normal"? For a lot of women over 40, that answer…

  46. 166. Carolina Reis de Oliveira: The Missing Link Between Skin and Longevity

    · 57 min · Episode 166

    If you think your skincare routine is protecting your skin, this conversation may make you look at your bathroom shelf differently. You've been taught to treat your skin like something cosmetic, something you maintain…

  47. 165. Cynthia Thurlow: The Menopause Gut - Why Healing Your Hormones Starts With Healing Your Gut

    · 1 h 05 min

    The gut and hormones have always been treated as two completely separate conversations in medicine, and that disconnect is quietly behind some of the most frustrating symptoms women experience in midlife. From bloating…

  48. 164. SXSW Panel: How To Actually Take Control Of Your Health In 2026 and Beyond

    · 56 min · Episode 164

    A lot of us are doing everything we can to stay healthy, taking supplements, wearing trackers, getting our labs done, and still ending up sick. And if you are like most people, you probably thought that was on you,…

  49. 163. Steve Chua: How Your Identity Is Either Healing Or Destroying Your Health

    · 1 h 00 min · Episode 163

    Most high performing executives will spend thousands optimizing their glucose levels, their sleep, and their body composition without ever stopping to ask why none of it makes them feel any better. The answer almost…

  50. 162. Dr. Meredith Broderick: What An Undiagnosed Sleep Disorder Is Quietly Doing To Your Brain And Body

    · 1 h 15 min · Episode 162

    A lot of people are walking around exhausted, foggy, moody, and struggling with their cardiovascular health blaming stress, diet, age, and everything in between, never once considering that the real culprit might be…

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