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Extend Podcast with Darshan Shah, MD

Darshan Shah, MD

214 episodes

Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan.

More about the show

Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results.

That's why this podcast is all about cutting through the noise on how to turn back the aging clock. I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health.

Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.

Episodes page 2 of 5

  1. 163. Steve Chua: How Your Identity Is Either Healing Or Destroying Your Health

    · 1 h 00 min · Episode 163

    Most high performing executives will spend thousands optimizing their glucose levels, their sleep, and their body composition without ever stopping to ask why none of it makes them feel any better. The answer almost…

  2. 162. Dr. Meredith Broderick: What An Undiagnosed Sleep Disorder Is Quietly Doing To Your Brain And Body

    · 1 h 15 min · Episode 162

    A lot of people are walking around exhausted, foggy, moody, and struggling with their cardiovascular health blaming stress, diet, age, and everything in between, never once considering that the real culprit might be…

  3. 161. McCall McPherson: Why Your Thyroid Is Being Undertested And Undertreated

    · 47 min

    Fatigue, brain fog, weight gain, hair loss, low libido, high cholesterol, and a doctor who keeps telling you your labs look normal. For the millions of people walking around with an undetected or poorly managed thyroid…

  4. 160. Dr. Kara Fitzgerald on Biological Age, Epigenetic Clocks, and the Future of Aging Reversal

    · 47 min · Episode 160

    Biological aging is no longer just a concept tied to time. It is something we can now measure, track, and influence through data, lifestyle, and targeted interventions that directly impact how our cells function and…

  5. 159: Dr. Anurag Singh: Urolithin A, Mitophagy, and Mitochondrial Health

    · 59 min · Episode 159

    Mitochondrial decline is one of the most overlooked drivers of aging, impacting energy, muscle function, cognitive performance, and immune resilience long before symptoms become obvious. Many of the changes we…

  6. 158. Dr. Kavin Mistry: Primal Health Design, Biological Aging, and Reconnecting with Human Biology

    · 1 h 02 min · Episode 158

    Modern life is quietly accelerating biological aging, from posture and movement patterns to sleep disruption, chronic stress, and constant digital stimulation. Many of the symptoms people experience daily, like pain,…

  7. 157. Dr. Tania Elliott: Allergies, Immune Health, and Hidden Toxins in Your Home

    · 1 h 04 min · Episode 157

    Allergies, chronic inflammation, and constant exposure to environmental toxins are reshaping how our immune system functions, often in ways that go unnoticed until symptoms appear. What many people see as isolated…

  8. 156. Dr. Judith Joseph: High-Functioning Depression, Anhedonia, and Reclaiming Joy

    · 42 min

    High-performing individuals often appear successful on the outside while quietly experiencing a loss of joy, emotional numbness, and chronic internal stress. This disconnect, often overlooked in traditional…

  9. 155. Dr. Eboni Cornish: Neural Longevity, Brain Inflammation, and the Hidden Root Causes of Mental Health Symptoms

    · 55 min

    Cognitive decline, mood disorders, and persistent neurological symptoms are often treated in isolation, even as underlying drivers like inflammation, infections, and blood flow dysfunction continue to go unaddressed.…

  10. 154. Dr. Rick Doblin - Part 2: Psychedelics, MDMA Therapy, and the Future of Mental Health

    · 56 min · Episode 154

    Mental health conditions like depression, PTSD, and trauma related disorders remain difficult to treat, especially when underlying cognitive and emotional patterns persist over time. Emerging research suggests…

  11. 153. Dr. Rick Doblin - Part 1: Psychedelics, MDMA Therapy, and the Future of Mental Health

    · 1 h 04 min

    Depression, PTSD, and trauma related disorders continue to challenge modern medicine, even as our understanding of the brain and consciousness rapidly evolves. New research suggests that certain therapies may help…

  12. 152. Nick Norwitz: Cholesterol Myths, Insulin Resistance, and the Real Drivers of Heart Disease

    · 1 h 18 min · Episode 152

    Cholesterol remains one of the most debated biomarkers in cardiovascular medicine, yet many people still misunderstand what it actually tells us about metabolic health and disease risk. As research evolves, the…

  13. 151. Ramses Alcaide: Brain Wearables, EEG, and the Future of Brain Health Tracking

    · 45 min · Episode 151

    Chronic stress, cognitive overload, and neurodegenerative disease are rising as modern life pushes the brain beyond what it was designed to handle. At the same time, most people still have almost no visibility into how…

  14. 150. Dr. Terry Grossman: Plasma Exchange, Detoxification, and the Future of Longevity Medicine

    · 1 h 41 min

    Chronic inflammation, environmental toxins, and metabolic dysfunction continue to accelerate aging and chronic disease across modern populations. Many of the biggest drivers of health decline remain invisible, quietly…

  15. 149. Kim Rogers: Parasites, Hidden Infections, and the Cleanse Protocol for Gut Health, Energy, and Recovery

    · 45 min

    Chronic symptoms often get labeled, managed, and medicated, yet the root cause can remain hidden. Parasites, mold exposure, Lyme disease, and microbial imbalances may quietly disrupt energy, digestion, immunity, and…

  16. 148. Fitz Koehler: The Four Pillars of Fitness and the Exact Formula for Strength, Fat Loss, and Longevity

    · 1 h 01 min

    Strength is the foundation of longevity. When muscle, cardiovascular fitness, mobility, balance, sleep, and nutrition align, performance improves, metabolism sharpens, and aging becomes something you influence rather…

  17. 147. Dr. David Luu: How AI Is Reshaping Preventive Care

    · 57 min · Episode 136

    Most people think medicine is about treating disease. What if the real future of healthcare is preventing illness and optimizing human potential long before symptoms appear. In this episode of Extend, we sit down with…

  18. 146. Dr. Joel Warsh: Vaccines, Ultra-Processed Foods for Kids, Screen Time, and the Modern Parent's Playbook

    · 1 h 08 min · Episode 146

    Raising healthy children today requires more discernment than ever. Between conflicting vaccine guidance, ultra processed food marketing, and the explosion of screen exposure, modern parents are navigating a landscape…

  19. 145. Dr. Dave Rabin: HRV, Vagal Tone, and the Science of Safety for Performance and Mental Health

    · 1 h 32 min · Episode 145

    Chronic stress is quietly reshaping how we think, perform, sleep, and recover. In a world optimized for productivity, we rarely prioritize the one variable that determines long term resilience: recovery. In this…

  20. 144. Dr. Mao Shing Ni: Fertility Optimization, Egg Freezing, and Menopause as "Second Spring"

    · 59 min · Episode 144

    Fertility is declining while menopausal symptoms are appearing earlier. Metabolic dysfunction, chronic stress, and environmental exposures are reshaping reproductive health for both women and men. In this episode of…

  21. 143. The Teen Health Revolution: Raising Resilient Teens in Digital Chaos

    · 51 min · Episode 143

    Teen mental health is deteriorating in real time, fueled by ultra processed food, chronic stress, and constant screen exposure. The earlier we intervene, the more resilient the biology and brain become. In this…

  22. 142. Dr. Tommy Wood: The Science of Brain Performance Optimization

    · 1 h 18 min

    Most conversations about brain health focus on intelligence or genetics. True cognitive performance depends on how the brain is trained, supported, and allowed to recover across decades of life. In this episode of…

  23. 141. Dr. Amy Shah: Hormone Havoc, Gut Health, and the New Menopause Playbook

    · 1 h 09 min · Episode 141

    Most women are taught to accept fatigue, weight gain, brain fog, and mood changes as a normal part of aging. What if the real issue has been overlooked gut health, muscle loss, and a medical system that failed to…

  24. 140. Dr. Kelly Casperson: The Hormone Truth About Women's Longevity

    · 1 h 28 min · Episode 140

    Most women are taught that aging means decline, less energy, less strength, and less desire. What if the real problem has never been age itself, but untreated hormone loss and outdated medical narratives. In this…

  25. 139. JJ Virgin: Muscle Over Weight Loss

    · 1 h 24 min · Episode 139

    Most people are told to lose weight to get healthy. What if that mindset is the reason metabolic health keeps getting worse, muscle keeps disappearing, and fat loss never lasts. In this episode of Extend, we sit down…

  26. 138. Dr. Idrees Mughal: Why Most Viral Health Claims Fail

    · 1 h 07 min · Episode 138

    Most people assume viral health advice is backed by solid science. What if much of it is built on cherry-picked studies, misleading mechanisms, and narratives designed to sell certainty rather than protect long-term…

  27. 137. Ariana Thacker: Mold Toxicity, Treatment Protocols + Genetic Susceptibility

    · 46 min

    Most people assume mold exposure causes allergies or respiratory issues. What if it is actually driving chronic inflammation, hormone disruption, and neurological symptoms that standard labs fail to detect. In this…

  28. 136. Dr. Goodenowe: Plasmalogens and the Hidden Science of Longevity

    · 1 h 09 min

    Most people think brain aging is inevitable. What if the real future of longevity is protecting cellular health long before symptoms appear. In this episode of Extend, we sit down with Dr. Dayan Goodenowe,…

  29. 135. Sarah Ann Macklin: Self-Compassion and Sustainable Behavior Change

    · 1 h 08 min · Episode 135

    Most people know what they should do to be healthy, yet still struggle to follow through. What if the real barrier is not discipline or knowledge, but mindset. In this episode of Extend, we sit down with Sarah Ann…

  30. 134. Dr. Jessica Shepherd: Stop the Decline: Perimenopause Strategies

    · 51 min · Episode 134

    Most people assume losing strength, energy, and bone health is inevitable as we age. But what if maintaining muscle, optimizing hormones, and protecting bone density were about targeting the right systems early rather…

  31. 133. Dr. Abid Husain: The Hidden Drivers of Heart Disease

    · 1 h 02 min · Episode 133

    Most people focus on cholesterol and plaque when thinking about heart health. The truth is, there are hidden drivers that can silently damage your arteries and increase cardiovascular risk. In this episode of Extend,…

  32. 132. Nathalie Niddam: Reverse Aging Signals with Bioregulators and Peptides

    · 50 min · Episode 132

    Most people assume fatigue, low energy, and age-related decline are unavoidable. What if supporting your body, optimizing recovery, and enhancing longevity were about activating the right systems, rather than chasing…

  33. 131. Dr. Elizabeth Yurth: The Science of Ketones, Hormones, and Faster Recovery

    · 1 h 04 min · Episode 131

    Most people assume joint pain, fatigue, and limited mobility are inevitable with age. But what if protecting your joints, optimizing recovery, and maintaining energy were about targeting the right systems early, rather…

  34. 130. Smarter Drinking: Cut Alcohol Without Sacrifice

    · 26 min · Episode 130

    How much control do you really have over your alcohol consumption and its effects on your health? Many people assume drinking is just part of social life, but science shows there are practical steps to reduce intake…

  35. 129. Ashley Koff: The GLP-1 Conversation Most People Are Missing

    · 1 h 02 min

    Most people think weight loss is about discipline, calories, or finding the right medication. But what if the real issue is that we've misunderstood how hormones, digestion, and recovery actually regulate metabolism in…

  36. 128. Hidden Environmental Toxins Are Destroying Your Health

    · 21 min · Episode 128

    How much control do you actually have over the toxins in your daily environment? Most people assume chemical exposure is unavoidable, but the science shows there are practical steps that can significantly reduce your…

  37. 127. Allison Evans: Hidden Household Toxins That Are Making You Sick

    · 1 h 13 min · Episode 127

    Toxin exposure rarely announces itself loudly, yet it quietly shapes hormone balance, immune resilience, mood, and neurological health long before a diagnosis appears. The real tension lies in the fact that these…

  38. 126. How to Fix Your Metabolic Health at Any Age

    · 29 min · Episode 126

    Most people think they're doing "enough" for their health, yet nearly 90% of Americans are metabolically unhealthy and don't know it. In this episode, I challenge outdated metrics like BMI, explain why sleep quality…

  39. 125. Best of Mental Health: The Foundation of Brain and Whole Body Health

    · 46 min · Episode 125

    Mental health is shaped by how well the brain produces energy, how well the nervous system remains under stress, and how effectively the mind adapts over time. When these systems begin to break down, problems often…

  40. 124. Best of Strength Training: Why Strength Determines How You Age

    · 31 min · Episode 124

    Over the past year on Extend, I've had powerful conversations with experts who all kept pointing back to the same foundation: strength training. So in this episode, I'm bringing together a Best Of compilation featuring…

  41. 123. Best of Metabolic Health: Why Metabolic Health Changes Everything

    · 24 min · Episode 123

    Metabolic health is the foundation that determines how your body produces energy, manages inflammation, regulates hormones, and protects you from chronic disease. When it breaks down, problems show up years later, long…

  42. 122. Dr. Mayim Bialik on Stress, Mental Health, and Human Connection

    · 1 h 19 min · Episode 122

    What if the stress you feel every day is not a personal failure, but a biological response to how modern life pulls at your nervous system? In this episode, I sit down with Dr. Mayim Bialik to explore why so many…

  43. 121. How to Protect Your Brain at Every Age

    · 36 min · Episode 121

    How much control do you actually have over how your brain ages? Most people assume memory loss and cognitive decline are inevitable, but the science tells a very different story. In this solo episode, I break down why…

  44. 120. Jess Kane: Your Cells Are Leaking, Here's How to Fix Them

    · 46 min · Episode 120

    Have you ever wondered why you can be "doing everything right" with your health and still feel inflamed, foggy, or depleted? The more I study longevity, the more I am convinced this has less to do with the latest hack…

  45. 119. Dr. Rocio Salas Whalen: How To Lose Weight On GLP-1s Without Losing Muscle

    · 1 h 01 min · Episode 119

    Most people still think GLP-1s are "weight loss shots," but what we are really doing is changing biology at the level of appetite and inflammation, with ripple effects across future generations. In this conversation, I…

  46. 118. Dr. Suzanne Steinbaum: A New Roadmap to Female Heart Health

    · 55 min

    Most people think heart disease is obvious and predictable, yet women often present with completely different warning signs that traditional testing fails to catch. We now have the tools to identify risk decades…

  47. 117. Dr. Steven Gundry: The Microbiome War Shaping Your Mind

    · 1 h 11 min

    Most people think about the gut as a digestive system, yet emerging research shows it functions more like a command center shaping immunity, metabolism, mood, and even coronary artery calcification. The surprising…

  48. 116. Dr. Stephanie Venn-Watson: The New Essential Fatty Acid

    · 48 min · Episode 116

    Most people hear "saturated fat" and think of something harmful, yet emerging research reveals that one specific fatty acid supports stronger cell membranes, healthier metabolic function, and better long-term…

  49. 115. Dr. Shivani Gupta: Heal Inflammation Through Ayurvedic Science

    · 1 h 06 min · Episode 115

    Most of us think inflammation is something we can fix with supplements, lab tests, or the latest diet trend. But what if the real solution comes from ancient wisdom that modern science is finally catching up to? In…

  50. 114. Julia Putzeys: The App That Decodes Your Food Lies

    · 45 min

    Most of us grew up thinking anything sold at the grocery store was safe to eat. But behind every "heart healthy," "high protein," or "low fat" label lies a different truth one built on ultra-processed ingredients,…

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