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Course10210300260 lectures

Transport Phenomena in Bioprocess Engineering

Prof. Selvaraju Narayanasamy · IIT Guwahati

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About

This course involves the study of momentum, heat, and mass transfer essential to understand and optimize biotechnological systems. This course introduces the fundamental principles, covering definitions, units, and dimensionless numbers critical to analyzing transport processes. It explores fluid flow dynamics, including rheology and the behavior of Newtonian and non-Newtonian fluids like fermentation broths. Also, heat and mass transfer principles are addressed, focusing on conduction, convection, diffusion, and their applications in bioprocess systems such as fermenters, packed beds, fluidized beds and distillation columns. Through theoretical insights and case studies, this course bridges concepts to practical bioprocess applications.

Intended audience: Undergraduate, Postgraduate & PhD students from Biotechnology, Industrial Biotechnology, Biochemical Engineering, Biosciences and Chemical Engineering

Prerequisites: Basics of Engineering mathematics

Lectures

Week 01: Introduction to Transport Processes

  1. Lecture 01: Course Introduction: Transport Phenomena YouTube
  2. Lecture 02: Fundamentals of Transport Phenomena - Part I YouTube
  3. Lecture 03: Fundamentals of Transport Phenomena - Part II YouTube
  4. Lecture 04: Dimensional Analysis and Dimensionless Numbers in Bioprocess Engineering - Part I YouTube
  5. Lecture 05: Dimensional Analysis and Dimensionless Numbers in Bioprocess Engineering - Part II YouTube

Week 02: Aspects of Rheology in Bioprocess

  1. Lecture 01: Aspect of Rheology in Bioprocess Engineering​ - Part I YouTube
  2. Lecture 02: Aspect of Rheology in Bioprocess Engineering​ - Part II YouTube
  3. Lecture 03: Non-Newtonian Fluids in Bioprocess Engineering YouTube
  4. Lecture 04: Rheology of Fermentation Broth: Behavior and its implications YouTube
  5. Lecture 05: Viscoelastic Fluids and Rheological Measurement Techniques YouTube

Week 03: Fluid Flow Dynamics

  1. Lecture 01: Introduction to Boundary Layer YouTube
  2. Lecture 02: Fluid flow Dynamics in Flat Plate YouTube
  3. Lecture 03: Fluid flow Dynamics in Circular Tube YouTube
  4. Lecture 04: Fluid flow Dynamics in Circular Tube (Contd.,) YouTube
  5. Lecture 05: Bernoulli's Equation YouTube

Week 04: Pumps in Bioprocess Engineering

  1. Lecture 1: Pumps in Bioprocess Engineering YouTube
  2. Lecture 2: NPSH and Cavitation: Concepts and Prevention Strategies YouTube
  3. Lecture 3: Fluid Flow Measurement YouTube
  4. Lecture 4: Fluid Flow Measurement (Contd.,) YouTube
  5. Lecture 5: Pressure Measurement YouTube

Week 05: Fluid Flow in Packed-Bed and Fluidized-Bed Column

  1. Lecture 01: Fundamentals of Flow Through Porous Media YouTube
  2. Lecture 02: Fundamentals of Darcy's Law and Packed-Bed Reactor Hydrodynamics YouTube
  3. Lecture 03: Hydrodynamics of Laminar Flow in Packed Beds and the Kozeny–Carman Equation YouTube
  4. Lecture 04: Turbulent Flow in Packed Beds and the Ergun Equation YouTube
  5. Lecture 05: Particle Shape Effects and Effective Particle Diameter in PBR YouTube

Week 06: Fluid Flow in Packed-Bed and Fluidized-Bed Column – cont.

  1. Lecture 01: Case Study: Design of an Enzyme Immobilized Packed-Bed Bioreactor for Continuous Operation YouTube
  2. Lecture 02: Fundamentals of Fluidized Bed Reactors YouTube
  3. Lecture 03: Minimum Fluidization Velocity and Bed Expansion in Fluidized-Bed Reactors YouTube
  4. Lecture 04: Minimum Bubbling Velocity in Fluidized-Bed Reactors YouTube
  5. Lecture 05: Case Study: Designing a Fluidized-Bed Bioreactor for Wastewater Treatment YouTube

Week 07: Introduction to Heat Transfer in Bioprocess

  1. Lecture 1: Fundamentals of Heat Transfer and Steady-State Conduction in Bioprocess Engineering​ YouTube
  2. Lecture 2: Convection and Radiation Heat Transfer​ YouTube
  3. Lecture 3: Heat Transfer Between Two Fluids​ YouTube
  4. Lecture 4: Principle of Heat Transfer: Condensation and Evaporation YouTube
  5. Lecture 5: Heat Transfer in Different Geometries YouTube

Week 08: Introduction to Heat Transfer in Bioprocess – cont.

  1. Lecture 01: Heat Exchangers in Bioprocess Engineering: Principles, Configurations, LMTD YouTube
  2. Lecture 02: Heat Exchanger Analysis : ε–NTU Method & Concept of Fouling YouTube
  3. Lecture 03: Introduction to Unsteady-State Heat Transfer & its application YouTube
  4. Lecture 04: Applications of Heat Transfer : Freezing and Agitated-Vessel Heat Transfer YouTube
  5. Lecture 05: Heat Transfer and Thermal Sterilisation in Bioprocess Engineering: Coils, Batch and Continuous Sterilisation Systems YouTube

Week 9: Introduction to Mass Transfer in Bioprocess

  1. Lecture 01: Fundamentals of Mass Transfer and Molecular Diffusion in Bioprocess Engineering YouTube
  2. Lecture 02: Interphase Mass Transfer and Convective Transport in Bioprocess Engineering YouTube
  3. Lecture 03: Convective and Liquid–Solid Mass Transfer in Bioprocess Engineering YouTube
  4. Lecture 04: Liquid–Liquid Mass Transfer in Bioprocess Engineering YouTube
  5. Lecture 05: Gas–Liquid Mass Transfer and Oxygen Transfer in Shake Flask System YouTube

Week 10: Introduction to Mass Transfer in Bioprocess – cont.

  1. Lecture 01: Mass Transfer Coefficients: Fundamentals, Significance and Experimental Determination YouTube
  2. Lecture 02: Measurement of Mass Transfer Coefficients (Contd.) and Scale-Up Considerations YouTube
  3. Lecture 03: Case Study: Gas-liquid and liquid-liquid mass transfer in a stirred-tank bioreactor YouTube
  4. Lecture 04: Case study: Gas-liquid and liquid-liquid mass transfer in stirred-tank bioreactor contd., YouTube
  5. Lecture 05: Analysis of diffusion through porous solids, crystalline solids and polymers YouTube

Week 11: Application of Heat and Mass Transfer

  1. Lecture 01: Fundamentals and Operations of Adsorption in Bioprocess Engineering YouTube
  2. Lecture 02: Adsorption Isotherms and Fixed-Bed Adsorption: Equilibrium, Mass Transfer and Column Design YouTube
  3. Lecture 03: Introduction to Distillation and Vapor–Liquid Equilibrium YouTube
  4. Lecture 04: Binary Distillation with Reflux — McCabe–Thiele Method and Tray Efficiency YouTube
  5. Lecture 05: Distillation of Multicomponent Mixtures: Equilibrium, Shortcut Design and Column Analysis YouTube

Week 12: Application of Heat and Mass Transfer – cont.

  1. Lecture 01: Fundamentals of Drying in Bioprocess Technology YouTube
  2. Lecture 02: Drying Kinetics, Transport Mechanism, and Freeze-Drying Fundamentals YouTube
  3. Lecture 03: Case Study: Application of Heat and Mass Transfer in Freeze-Drying YouTube
  4. Lecture 04: Case Study: Application of Heat and Mass Transfer in Freeze-Drying contd., YouTube
  5. Lecture 05: Downstream Processing in Bioprocess Engineering YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Guwahati
Department
Biotechnology
Teacher
Prof. Selvaraju Narayanasamy
Level
Undergraduate
Language
English
Subjects
Biology
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
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