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Course8.591J / 7.81J,7.3224 lectures31 h 49 min

Systems Biology

Prof. Jeff Gore · Massachusetts Institute of Technology

Start with lecture 1 At MIT OpenCourseWare

About

This course provides an introduction to cellular and population-level systems biology with an emphasis on synthetic biology, modeling of genetic networks, cell-cell interactions, and evolutionary dynamics. Cellular systems include genetic switches and oscillators, network motifs, genetic network evolution, and cellular decision-making. Population-level systems include models of pattern formation, cell-cell communication, and evolutionary systems biology.

Lectures

Lecture Videos

  1. Introduction to the Class and Overview of Topics 1 h 8 min · Video
  2. Input Function, Michaelis-Menten kinetics, and Cooperativity 1 h 18 min · Video
  3. Autoregulation, Feedback and Bistability 1 h 19 min · Video
  4. Synthetic Biology and Stability Analysis in the Toggle Switch 1 h 20 min · Video
  5. Oscillatory Genetic Networks 1 h 22 min · Video
  6. Graph Properties of Transcription Networks 1 h 22 min · Video
  7. Feed-forward Loop Network Motif 1 h 22 min · Video
  8. Introduction to Stochastic Gene Expression 1 h 21 min · Video
  9. Causes and Consequences of Stochastic Gene Expression 1 h 21 min · Video
  10. Stochastic Modeling 1 h 22 min · Video
  11. Life at Low Reynolds Number 1 h 20 min · Video
  12. Robustness and Bacterial Chemotaxis 1 h 19 min · Video
  13. Robustness in Development and Pattern Formation 1 h 22 min · Video
  14. Microbial Evolution Experiments and Optimal Gene Circuit Design 1 h 20 min · Video
  15. Evolution in Finite Populations 1 h 21 min · Video
  16. Clonal Interference and the Distribution of Beneficial Mutations 1 h 22 min · Video
  17. Fitness Landscapes and Sequence Spaces 1 h 19 min · Video
  18. Evolutionary Games 1 h 21 min · Video
  19. Survival in Fluctuating Environments 1 h 19 min · Video
  20. Parasites, the Evolution of Virulence and Sex 1 h 19 min · Video
  21. Interspecies Interactions 1 h 22 min · Video
  22. Ecosystem Stability, Critical Transitions, and Biodiversity 1 h 21 min · Video
  23. Dynamics of Populations in Space 1 h 21 min · Video
  24. The Neutral Theory of Ecology 1 h 18 min · Video

Syllabus and materials

At MIT OpenCourseWare, as the course publishes them.

Credits and licence

Institution
Massachusetts Institute of Technology
Department
Physics; Biology
Teacher
Prof. Jeff Gore
Term
Fall 2014
Level
Undergraduate
Language
English
Subjects
Physics, Biology, Computer science, Engineering
Source
MIT OpenCourseWare
Licence
CC BY-NC-SA 4.0, as MIT OpenCourseWare states it. Non-commercial use only. MIT OpenCourseWare's terms
Attribution
Prof. Jeff Gore. Systems Biology. Fall 2014. Massachusetts Institute of Technology: MIT OpenCourseWare, https://ocw.mit.edu/. License: Creative Commons BY-NC-SA.
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