A Laboratory Guide to Clinical Hematology

by Valentin Villatoro and Michelle To

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This text explores the principles of clinical hematology and is written for aspiring clinical laboratory professionals who perform a wide variety of basic and advanced hematology testing on whole blood, serum, urine, cerebrospinal fluids and other body fluids.

Description from LibreTexts.

Publisher
Northern Alberta Institute of Technology
Subjects
Medicine, Allied Health
Licence
CC BY-NC 4.0, as LibreTexts states it. Non-commercial use only.
Who can read
Teens profiles and older, judged from its title and subjects

Contents

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  1. Front Matter
  2. TitlePage
  3. InfoPage
  4. Table of Contents
  5. Licensing
  6. 1: Red Blood Cells- Normal Morphology
  7. 1.1: Red Blood Cell Maturation
  8. 1.2: Red Blood Cell Indices, Colour, and Size
  9. 2: Red Blood Cells- Abnormal RBC Morphology
  10. 2.1: Poikilocytosis
  11. 2.2: Acanthocytes (Spur Cells)
  12. 2.3: Agglutination
  13. 2.4: Bite (Keratocyte) and Blister (Helmet) Cells
  14. 2.5: Dimorphic Population
  15. 2.6: Echinocytes (Burr Cells)
  16. 2.7: Elliptocytes and Ovalocytes
  17. 2.8: Pyknocytes
  18. 2.9: Rouleaux
  19. 2.10: Schistocytes
  20. 2.11: Sickle Cells (Drepanocytes)
  21. 2.12: Spherocytes
  22. 2.13: Stomatocytes
  23. 2.14: Target Cells (Codocytes)
  24. 2.15: Tear Cells (Dacrocytes, Teardrops)
  25. 3: Red Blood Cells- Abnormal RBC Inclusions
  26. 3.1: Basophilic Stippling
  27. 3.2: Cabot Rings
  28. 3.3: Heinz Bodies
  29. 3.4: Hemoglobin H (Hb H)
  30. 3.5: Hemoglobin C Crystals
  31. 3.6: Hemoglobin SC Crystals
  32. 3.7: Howell-Jolly Bodies
  33. 3.8: Pappenheimer Bodies (Siderotic Granules)
  34. 3.9: Bacteria and Fungi
  35. 3.10: Malaria
  36. 3.11: Babesia
  37. 3.12: Trypanosomes
  38. 4: Red Blood Cells- Hypochromic, Microcytic Anemias
  39. 4.1: Iron Deficiency Anemia (IDA)
  40. 4.2: Anemia of Chronic Inflammation/Disease (ACI/ACD)
  41. 4.3: Sideroblastic Anemia
  42. 4.4: Thalassemia
  43. 4.5: Iron Studies
  44. 5: Red Blood Cells- DNA Metabolism Abnormalities and Bone Marrow Failure
  45. 5.1: Megaloblastic Anemia
  46. 5.2: Non-Megaloblastic Macrocytic Anemia
  47. 5.3: Aplastic Anemia
  48. 6: Red Blood Cells- Introduction to Hemolytic Anemias
  49. 6.1: Introduction to Hemolytic Anemias
  50. 7: Red Blood Cells- Hemoglobinopathies
  51. 7.1: Normal Hemoglobin Structure
  52. 7.2: Sickle Cell (Hemoglobin SS) Disease
  53. 7.3: Sickle Cell Trait (Hemoglobin AS)
  54. 7.4: Hemoglobin C (Hb CC) Disease
  55. 7.5: Hemoglobin SC Disease
  56. 8: Red Blood Cells- Extrinsic Defects Causing Hemolytic Anemias
  57. 8.1: Microangiopathic Hemolytic Anemias (MAHAs)
  58. 8.2: Macroangiopathic Hemolytic Anemias
  59. 8.3: Immune-Mediated Hemolytic Anemias
  60. 8.4: Infectious Agents
  61. 9: Red Blood Cells- Intrinsic Defects of the RBC Membrane Causing Hemolytic Anemia
  62. 9.1: Hereditary Spherocytosis
  63. 9.2: Hereditary Elliptocytosis and Related Variants
  64. 9.3: Hereditary Stomatocytosis Syndromes
  65. 9.4: Hereditary Acanthocytosis (Abetalipoproteinemia)
  66. 9.5: Paroxysmal Nocturnal Hemoglobinuria (PNH)
  67. 9.6: Glucose-6-phosphate Dehydrogenase (G6PD) Deficiency
  68. 9.7: Pyruvate Kinase (PK) Deficiency
  69. 10: White Blood Cells and Platelets- Normal Morphology
  70. 10.1: Granulocytes and Granulocyte Maturation
  71. 10.2: Lymphocytes
  72. 10.3: Plasma Cells
  73. 10.4: Monocytes
  74. 10.5: Macrophages
  75. 10.6: Megakaryocytes
  76. 10.7: Platelets
  77. 11: White Blood Cells- Non-Malignant Leukocyte Disorders
  78. 11.1: Neutrophil Hyposegmentation
  79. 11.2: Neutrophil Hypersegmentation
  80. 11.3: Toxic Changes
  81. 11.4: Pelger-Huet Anomaly
  82. 11.5: Chediak-Higashi Syndrome
  83. 11.6: Alder-Reilly Anomaly
  84. 11.7: May-Hegglin Anomaly
  85. 11.8: Chronic Granulomatous Disease
  86. 11.9: Infectious Mononucleosis/Reactive Lymphocytes
  87. 12: White Blood Cells- Acute Leukemia
  88. 12.1: Introduction to Leukemias
  89. 12.2: Acute Lymphoblastic Leukemia (ALL)
  90. 12.3: Acute Myelogenous Leukemia (AML)
  91. 12.4: Acute Promyelocytic Leukemia (APL)
  92. 12.5: Cytochemical Testing
  93. 12.6: Flow Cytometry, Cytogenetics and Molecular Genetics
  94. 13: White Blood Cells- Mature Lymphoid Neoplasms
  95. 13.1: Introduction to Mature Lymphoid Neoplasms
  96. 13.2: Chronic Lymphocytic Leukemia (CLL)
  97. 13.3: Hairy Cell Leukemia (HCL)
  98. 13.4: Waldenstrom Macroglobulinemia
  99. 13.5: Monoclonal Gammopathy of Undetermined Significance (MGUS)
  100. 13.6: Plasma Cell Myeloma (Multiple Myeloma)
  101. 14: White Blood Cells- Myeloproliferative Neoplasms (MPN)
  102. 14.1: Introduction to Myeloproliferative Neoplasms (MPNs)
  103. 14.2: Chronic Myelogenous Leukemia (CML)
  104. 14.3: Polycythemia Vera (PV)
  105. 14.4: Essential Thrombocythemia (ET)
  106. 14.5: Primary Myelofibrosis (PMF)
  107. 15: White Blood Cells- Myelodysplastic Syndromes (MDS)
  108. 15.1: Introduction to Myelodysplastic Syndromes (MDS)
  109. 15.2: MDS- Dyserythropoiesis, Dysmyelopoiesis and Dysmegakaryopoiesis
  110. Back Matter
  111. Index
  112. Glossary
  113. Detailed Licensing