8: Red Blood Cells- Extrinsic Defects Causing Hemolytic Anemias

A Laboratory Guide to Clinical Hematology · LibreTexts

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    • 8.1: Microangiopathic Hemolytic Anemias (MAHAs)
      This page discusses Microangiopathic Hemolytic Anemias (MAHAs), which involve red blood cell fragmentation due to microthrombi, leading to hemolysis and thrombocytopenia. Key indicators include schistocytes, polychromasia, and low platelet counts. It covers associated conditions like DIC, TTP, HUS, and HELLP Syndrome, along with laboratory findings such as decreased hemoglobin and platelets, increased reticulocytes, and elevated unconjugated bilirubin.
    • 8.2: Macroangiopathic Hemolytic Anemias
      This page covers three types of traumatic hemolytic anemia: Traumatic Cardiac Hemolytic Anemia, caused by mechanical trauma from prosthetic valves, showing decreased hemoglobin and increased reticulocytes; Exercise-induced Hemoglobinuria, resulting from exercise stress; and Thermal Injury, due to burns damaging red blood cells.
    • 8.3: Immune-Mediated Hemolytic Anemias
      This page covers hemolytic anemias, which result from auto-antibodies and allo-antibodies. They are classified into warm (IgG) and cold (IgM) types, with conditions such as WAIHA and CAD. Additionally, it explores drug-induced hemolytic anemia, detailing mechanisms like autoantibody induction.
    • 8.4: Infectious Agents
      This page covers malarial infection caused by Plasmodium parasites from Anopheles mosquitoes, detailing its life cycle, symptoms (fever and chills), diagnostics, and treatment. It highlights malaria's significant global health impact in tropical areas and preventive measures like insecticide-treated nets and antimalarial drugs. Additionally, it discusses emerging challenges in malaria control, including drug resistance and climate change.

    This page titled 8: Red Blood Cells- Extrinsic Defects Causing Hemolytic Anemias was last modified on Fri, 11 Sep 2026 16:39:55 GMT and is shared under a CC BY-NC 4.0 license and was authored, remixed, and/or curated by Valentin Villatoro and Michelle To (Open Education Alberta) via source content that was edited to the style and standards of the LibreTexts platform.