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: An image from a bone marrow smear showing a plasma cell. Note the perinuclear clearing surrounding the nucleus. 100z oil immersion. From MLS Collection, University of Alberta, https://doi.org/10.7939/R30C4T111

: An image from a bone marrow smear with a plasma cell (indicated by an arrow). 100x oil immersion. From MLS Collection, University of Alberta, https://doi.org/10.7939/R3JM23X5J

Notes: The maturation of a lymphocyte to a plasma cell marks the production of immunoglobulins. Lymphocytes that mature into plasma cells are of B lineage.¹

Nucleus-to-Cytoplasm Ratio: 2:1 to 1:1 ²

Nucleoli: None ^1,2

Nucleus:^1,2

Round or oval

Eccentrically located

Coarse, clumpy, dark purple staining chromatin

Cytoplasm:^1,2

Abundant

Darkly basophilic

Perinuclear (clear) zone may be seen around the nucleus (Representing the golgi body)

Vacuoles may be present

Normal % in Bone Marrow: 0-1% ^1,2

Normal % in Peripheral Blood: 0% ^1,2

References:

1. Williams L, Finnegan K. Lymphocytes. In: Clinical laboratory hematology. 3rd ed. New Jersey: Pearson; 2015. p. 122-43.

2. Rodak BF, Carr JH. Lymphocyte maturation. In: Clinical hematology atlas. 5th ed. St. Louis, Missouri: Elsevier Inc.; 2017. p. 79-88.

This page titled 10.3: Plasma Cells was last modified on Sat, 02 Sep 2023 08:16:18 GMT and is shared under a CC BY-NC 4.0 license and was authored, remixed, and/or curated by Valentin Villatoro and Michelle To (Open Education Alberta) via source content that was edited to the style and standards of the LibreTexts platform.

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