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Course10310678460 lectures

Pharmaceutical Crystal Engineering for Design, Development and Scale-up for Pharmaceutical Solids

Prof. Dinesh Kumar · IIT (BHU) Varanasi

Start with lecture 1 At NPTEL

About

The course will cover all aspects of the subject including crystallization of active pharmaceutical ingredient, intermediates as well as final products. In addition, precipitations and amorphous solids will be covered and the differences between amorphous solids and crystalline solids will be discussed. Solid state pharmaceutics supporting advanced characterization tools are included as well. Upon the completion of the course, student shall be able to apply scientific principles to the design and development of pharmaceutical crystallization processes.

Intended audience: UG PG students interested in pharmaceutical crystal engineering and solid-state pharmaceutical characterization

Prerequisites: Basics understanding of crystals, crystal engineering, solid pharmaceutical formulations

Lectures

Week 1

  1. Introduction to Crystallisation Terminologies YouTube
  2. Crystalline Solids - Introduction & Types YouTube
  3. Stages of Crystallization YouTube
  4. Crystal Growth Theories & Solubility YouTube
  5. Metastable Zone Width MSZW & Ostwald Steprule YouTube

Week 2

  1. Crystallization Basics & Types of Crystalline Materials YouTube
  2. Crystallization Process, Methods of Crystallization, Factors Affecting Crystallization YouTube
  3. Evaporative Crystallization YouTube
  4. Anti Solvent Crystallization YouTube
  5. Melt Crystallization, Crystallization of Chiral Compounds YouTube

Week 3

  1. Phases & Phase Diagrams YouTube
  2. Yield & Productivity of Pharmaceutical Crystallization Process YouTube
  3. Filtration, Washing & drying after crystallization YouTube
  4. Miscellaneouse facter for Desigen a Crystallization Process YouTube
  5. Problems due to Improper Process Design and Industrial Aspects YouTube

Week 4

  1. Batch vs Continuous Crystallization YouTube
  2. Crystallizers Used in Continuous Crystallization YouTube
  3. Cooling Continuous Crystallization YouTube
  4. Continuous Manufacturing in Pharma Industry YouTube
  5. AI ML in Pharmaceutical Manufaturing and Pharma Indusary 4 0 YouTube

Week 5

  1. Polymorphism & It's Impact on Prarmaceutical Properties YouTube
  2. Disappearing Polymorphs & Mechanisms of Polymorphic Interconversion YouTube
  3. Methods of Polymorph Screening YouTube
  4. Solid State Characterization of Polymorphs YouTube
  5. Effect of Polymorphism on Pharmaceutical Processing YouTube

Week 6

  1. Basic Introduction, History, Type of Cocrystals YouTube
  2. Prerequisite Criteria for Coformers Selection to Design Cocrystals YouTube
  3. Compution Approaches for the Selection of Coformers YouTube
  4. Laboratory Methods for Sereening of Cocrystals YouTube
  5. Application, Characterization & Regulatory Aspects of Cocrystals YouTube

Week 7

  1. Introduction, Thermodynamics & Pharmaceutical Importance of Hydrates or Solvates YouTube
  2. Classification of Hydrates YouTube
  3. Kinetics & Mechanism of Dehydration or Hydration YouTube
  4. Preparation & Characterization of Hydrates & Solvates YouTube
  5. Stability & Regulatory aspects of Hydrae Solvates YouTube

Week 8

  1. FTIR Spectroscopy for Solid State Pharmaceutics YouTube
  2. XRD for Solid State Pharmaceutics YouTube
  3. Electon Diffraction & ssNMR Application in Pharmaceuticals YouTube
  4. Raman Spectrocopy for Solid State Pharmaceutiecs YouTube
  5. Solid State UV & Surface Free Energy Calculations YouTube

Week 9

  1. Introduction to Thermal Analysis & Its Applications in Pharmaceutical Industry YouTube
  2. Applications of DSC in Pharmaceutical Industry YouTube
  3. Practical Considerations & Celibration of DSC YouTube
  4. Thermolravimetric Analysis & Its Applications in Pharmaceuticals YouTube
  5. Isothermal Microcalorimetry, Hot Stage Microscopy & Dynamic Vapor Sorption Analyis YouTube

Week 10

  1. Quality by Design QbD for DS & DP Manufacturing YouTube
  2. Process Analytical Technology PAT YouTube
  3. Other PAT Tools, Benefits & Industrial Concerns YouTube
  4. Pharmaceutical Crystallization Scale up & SUPAC YouTube
  5. Process Safety in DS & DP Manufacturing YouTube

Week 11

  1. Physicochemical Characterization of Pharmaceuticas Solid Forms YouTube
  2. Impact of Amorphous forms on Pharmaceutical Properties YouTube
  3. Mechanical Studies of Pharmaceutical Solid Forms YouTube
  4. Impact of Pharmaceutical Solid forms on Powder Flow Properties YouTube
  5. Advancements in Solid Particle Size & Shame Measurements YouTube

Week 12

  1. Stability Studies of DS and DP YouTube
  2. Stability Testing Aspects of Formulation Development and Preformulation Studies YouTube
  3. API Coprocessing Introduction and Routes of Coprocessing YouTube
  4. Molecular Modelling & Simulation studies for Polymorph & Crystal Habit YouTube
  5. Molecular Modelling & Simulation studies of Amorphous Solid Dispersions & Cocrystals YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT (BHU) Varanasi
Department
Chemical Engineering
Teacher
Prof. Dinesh Kumar
Level
Undergraduate
Language
English
Subjects
Chemistry, Engineering
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge. Coordinated by IIT Madras.
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