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Course10310600164 lectures

Medicinal Chemistry of Antimicrobial Agent

Prof. Deepak Kumar · IIT (BHU) Varanasi

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About

The course aims to provide students with a comprehensive understanding of antimicrobial drugs structure, chemistry and therapeutic values. The subject will emphasize on the chemistry, mechanism of action, metabolism, adverse effects, Structure Activity Relationships (SAR), therapeutic uses and synthesis of important drugs. This course sets the stage for exploring the fascinating world of antimicrobial drugs.

Intended audience: UG PG students interested in Chemistry and Medicinal ChemistryPREREQUISITES: Basics understanding of Chemistry, Pharmaceutical Chemistry, and Pharmacology

Lectures

Week 1

  1. Introduction & Historical Foundations: Historical background and General principles of antibiotics YouTube
  2. Discovery and development of b-Lactam antibiotics YouTube
  3. b-Lactam antibiotics (Penicillin) YouTube
  4. β-lactam antibiotics: Cephalosporin YouTube
  5. β-lactam antibiotics: Carbapenem and Monobactam YouTube
  6. β Lactam Antibiotics MCQs YouTube

Week 2

  1. Aminoglycosides YouTube
  2. Streptomycin YouTube
  3. Kanamycin YouTube
  4. Neomycin YouTube
  5. General Overview of other aminoglycosides YouTube
  6. Aminoglycosides MCQs YouTube

Week 3

  1. Tetracyclins YouTube
  2. Tetracyclin (as an individual drug) YouTube
  3. Doxycycline YouTube
  4. Tetracycline Synthesis by the Myers route YouTube
  5. Tigecycline YouTube
  6. Tetracyclines MCQs YouTube

Week 4

  1. Antitubercular Agents YouTube
  2. Isoniazid and Ethambutol YouTube
  3. Pyrazinamide YouTube
  4. Rifampicin YouTube
  5. Dapsone YouTube
  6. Anti mycobacterial Agents MCQs YouTube

Week 5

  1. Quinolones YouTube
  2. Fluoroquinolone and Synthesis of Ciprofloxacin YouTube
  3. Quinolones MCQs YouTube
  4. Fluoroquinolones- Ofloxacin and Levofloxacin YouTube
  5. Fluoroquinolones- MCQs YouTube

Week 6

  1. Overview on Viruses YouTube
  2. Amantadine and Rimantidien YouTube
  3. Amantadine and Rimantadine MCQs YouTube
  4. Acyclovir: Synthesis and Mechanism of Action YouTube
  5. Lamivudine: Synthesis and Mechanism of Action YouTube

Week 7

  1. Antiretrovirals (HIV therapy): Introduction and Classification YouTube
  2. Antiretrovirals (HIV therapy): Classifications YouTube
  3. Antiretrovirals (HIV therapy) MCQs YouTube
  4. Retroviral Protease Inhibitors - PIs YouTube
  5. Ritonavir Synthesis and SAR YouTube

Week 8

  1. Introduction to fungal pathogens YouTube
  2. Polyene Antibiotics YouTube
  3. MCQ on Antifungal Agents & Polyene Antibiotics YouTube
  4. Inhibitors of Cell wall Biosynthesis- Echinocandins YouTube
  5. Drugs Acting through other mechanisms YouTube

Week 9

  1. Synthesis of Fungal Cell Wall Components: Ergosterol Biosynthesis YouTube
  2. Azole Antifungals Mechanism of Action & Metabolism YouTube
  3. MCQs on Ergosterol biosynthesis and Azole inhibitors YouTube
  4. Ketoconazole and Clotromoxazole YouTube
  5. Classification of Antifungal Drugs and MCQs YouTube

Week 10

  1. Introduction to Antimalarial Drugs YouTube
  2. MCQs on Antimalarial Drugs YouTube
  3. Life Cycle of the Malarial Parasite and Antimalarial Drugs YouTube
  4. Quinoline based Antimalarial Drugs YouTube
  5. Artemisinin and Other Antimalarial Drugs YouTube

Week 11

  1. Metronidazole - Synthesis & Mechanism of Action YouTube
  2. Nitroimidazole, Synthesis & Mechanism of Action YouTube
  3. Emetin Synthesis & Mechanism of Action YouTube
  4. Dehydroemtin & Luminal Amoebicides YouTube
  5. Anti-Protozoal or Amoebic Drugs YouTube

Week 12

  1. Helminth Infection YouTube
  2. Helminth Infection, Anthelmintics, Classification, Introduction YouTube
  3. Anthelmintics Synthesis YouTube
  4. Anthelmintics - Ivermectin & Praziquantel YouTube
  5. MCQs on Antihelmintic Drugs YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT (BHU) Varanasi
Department
Chemical Engineering
Teacher
Prof. Deepak Kumar
Level
Undergraduate
Language
English
Subjects
Chemistry, Engineering
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge. Coordinated by IIT Madras.
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