Course10310678559 lectures
Pharmacological and Toxicological Screening Methods
Prof. Vinod Tiwari · IIT (BHU) Varanasi
About
This 12-week course, Pharmacological and Toxicological Screening Methods, offers a comprehensive exploration of the methodologies and tools vital for assessing the therapeutic potential and safety profiles of new drugs, chemicals, and biological compounds. The program begins with foundational principles of Pharmacological assays, emphasizing toxicity types, dose-response relationships, and safety thresholds. As the course progresses, participants delve into advanced screening techniques, including in vitro assays (e.g., cell-based models, enzyme inhibition studies) and in vivo methods (e.g., animal models for efficacy and toxicity). Additionally, the curriculum incorporates OECD guidelines, ethical considerations in animal research, and alternatives to animal experimentation, providing a well-rounded understanding of preclinical evaluation techniques.
Intended audience: Pharmacy professionals, Pharmacologists, Biologists, Biotechnologists
Prerequisites: The participants should have basic knowledge of biology. A keen interest in the domains of biochemistry, physiology, and molecular biology is desirable.
Lectures
Week 1
- Morals of Animal Testing & 3R Strategy
- Common Laboratory Animals & Maintenance Part - A
- Common Laboratory Animals & Maintenance Part - B
- CCSEA Guidelines for Experimentation on Animals Part - 1
- CCSEA Gidelines for Experimentation on Animals - Part 2
Week 2
- Form B per rule 8a for Submission of Research protocols
- Anesthesia and Euthanasia of Experimental Animals
- Alternatives to Animals Usage in Research
- In vitro Models
- Stem Cell Therapy, Skin Patch Test
Week 3
- In silico Models, Microfluidic Chips & Recent Trends
- High Throughput Screening HTS Assays
- Western Blotting
- Assay and its Types - Part A
- Assay & its Types - Part B
Week 4
- Introduction to Alzheimer's Disease
- Symptoms & Pathophysiology of Alzheimer's Disease
- Screening Models of Alzheimer's Disease
- Introduction to Parkinson's Desease
- Models of Parkinson,s Disease
Week 5
- Introduction to Depression
- Diagnosis & Pharmacotherapeutics for the Treatment of Depression
- Models for the Screening of Anti depressant Drugs
- Behavioural Tests for the Assessment of Anti depressant Activity
Week 6
- Introduction to Pain and Its Pathobiology
- Preclinical Models for Neuropathic Pain
- Preclinical Models for Inflammatory Pain
- Behavioural Assays for Pain Measurement in Animals
- Behavioural Assays for Spontaneous Pain Assessment
Week 7
- Introduction to Diabetes
- Pathophysiology & Diagnosis of Diabetes
- Current Pharmacotherapeutics Used for the Treatment of Diabetes Mellitus
- In Vitro Models of Diabetes Mellitus
- In Vitro Models of Diabetes Mellitus
Week 8
- Pharmacological Screening & Its Types
- Transgenic Animals Production & Maintenance
- Humanized Mouse Introduction
- Application of Transgenic Animals
- Applications of Humanized Mouse Model
Week 9
- Introduction to Toxicology
- Mechanisms of Toxicity & Toxicant Action
- Toxicity Testing Studies as per OECD Guidelines
- ICH Guidelines for Drug Toxicity Studies
- Good Laboratry Practices for Safety Studies
Week 10
- Acute & Sb Acute Toxicity Studies
- Chronic Toxicity Studies
- Mutagenicity & Genotoxicity Studies
- Teratogenicity Studies
- Reproductive Toxicology
Week 11
- Neurobehavioral Toxicology
- Cardiovascular Toxicity
- Respiratory Toxicology
- Dermal Toxicology
- Toxicology of The Liver
Week 12
Syllabus and materials
At NPTEL, as the course publishes them.
Credits and licence
- Institution
- IIT (BHU) Varanasi
- Department
- Chemical Engineering
- Teacher
- Prof. Vinod Tiwari
- Level
- Undergraduate
- Language
- English
- Subjects
- Chemistry, Engineering
- Source
- NPTEL
- Licence
- CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
- Attribution
- NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge. Coordinated by IIT Madras.
- Who can watch
- NPTEL gives no rating. Invisible Network shows it to Teens profiles and older, judged from what the source says about it. How courses are placed