Learn · Pharmaceutical Crystal Engineering for Design, Development and Scale-up for Pharmaceutical Solids
Lecture 49 of 60Week 10
Pharmaceutical Crystallization Scale up & SUPAC
Prof. Dinesh Kumar · IIT (BHU) Varanasi
Credits and licence
- From
- Pharmaceutical Crystal Engineering for Design, Development and Scale-up for Pharmaceutical Solids, IIT (BHU) Varanasi (at NPTEL)
- Licence
- CC BY-NC-SA, as NPTEL states it. Non-commercial use only.
- Attribution
- NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge. Coordinated by IIT Madras.
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All the lectures
- Introduction to Crystallisation Terminologies
- Crystalline Solids - Introduction & Types
- Stages of Crystallization
- Crystal Growth Theories & Solubility
- Metastable Zone Width MSZW & Ostwald Steprule
- Crystallization Basics & Types of Crystalline Materials
- Crystallization Process, Methods of Crystallization, Factors Affecting Crystallization
- Evaporative Crystallization
- Anti Solvent Crystallization
- Melt Crystallization, Crystallization of Chiral Compounds
- Phases & Phase Diagrams
- Yield & Productivity of Pharmaceutical Crystallization Process
- Filtration, Washing & drying after crystallization
- Miscellaneouse facter for Desigen a Crystallization Process
- Problems due to Improper Process Design and Industrial Aspects
- Batch vs Continuous Crystallization
- Crystallizers Used in Continuous Crystallization
- Cooling Continuous Crystallization
- Continuous Manufacturing in Pharma Industry
- AI ML in Pharmaceutical Manufaturing and Pharma Indusary 4 0
- Polymorphism & It's Impact on Prarmaceutical Properties
- Disappearing Polymorphs & Mechanisms of Polymorphic Interconversion
- Methods of Polymorph Screening
- Solid State Characterization of Polymorphs
- Effect of Polymorphism on Pharmaceutical Processing
- Basic Introduction, History, Type of Cocrystals
- Prerequisite Criteria for Coformers Selection to Design Cocrystals
- Compution Approaches for the Selection of Coformers
- Laboratory Methods for Sereening of Cocrystals
- Application, Characterization & Regulatory Aspects of Cocrystals
- Introduction, Thermodynamics & Pharmaceutical Importance of Hydrates or Solvates
- Classification of Hydrates
- Kinetics & Mechanism of Dehydration or Hydration
- Preparation & Characterization of Hydrates & Solvates
- Stability & Regulatory aspects of Hydrae Solvates
- FTIR Spectroscopy for Solid State Pharmaceutics
- XRD for Solid State Pharmaceutics
- Electon Diffraction & ssNMR Application in Pharmaceuticals
- Raman Spectrocopy for Solid State Pharmaceutiecs
- Solid State UV & Surface Free Energy Calculations
- Introduction to Thermal Analysis & Its Applications in Pharmaceutical Industry
- Applications of DSC in Pharmaceutical Industry
- Practical Considerations & Celibration of DSC
- Thermolravimetric Analysis & Its Applications in Pharmaceuticals
- Isothermal Microcalorimetry, Hot Stage Microscopy & Dynamic Vapor Sorption Analyis
- Quality by Design QbD for DS & DP Manufacturing
- Process Analytical Technology PAT
- Other PAT Tools, Benefits & Industrial Concerns
- Pharmaceutical Crystallization Scale up & SUPAC
- Process Safety in DS & DP Manufacturing
- Physicochemical Characterization of Pharmaceuticas Solid Forms
- Impact of Amorphous forms on Pharmaceutical Properties
- Mechanical Studies of Pharmaceutical Solid Forms
- Impact of Pharmaceutical Solid forms on Powder Flow Properties
- Advancements in Solid Particle Size & Shame Measurements
- Stability Studies of DS and DP
- Stability Testing Aspects of Formulation Development and Preformulation Studies
- API Coprocessing Introduction and Routes of Coprocessing
- Molecular Modelling & Simulation studies for Polymorph & Crystal Habit
- Molecular Modelling & Simulation studies of Amorphous Solid Dispersions & Cocrystals