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Illustration showing basic steps used in microarray technology.

CourseHST.51219 lectures

Genomic Medicine

Prof. Isaac Kohane · Massachusetts Institute of Technology

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About

This course reviews the key genomic technologies and computational approaches that are driving advances in prognostics, diagnostics, and treatment. Throughout the semester, emphasis will return to issues surrounding the context of genomics in medicine including: what does a physician need to know? what sorts of questions will s/he likely encounter from patients? how should s/he respond? Lecturers will guide the student through real world patient-doctor interactions. Outcome considerations and socioeconomic implications of personalized medicine are also discussed. The first part of the course introduces key basic concepts of molecular biology, computational biology, and genomics. Continuing in the informatics applications portion of the course, lecturers begin each lecture block with a scenario, in order to set the stage and engage the student by showing: why is this important to know? how will the information presented be brought to bear on medical practice? The final section presents the ethical, legal, and social issues surrounding genomic medicine. A vision of how genomic medicine relates to preventative care and public health is presented in a discussion forum with the students where the following questions are explored: what is your level of preparedness now? what challenges must be met by the healthcare industry to get to where it needs to be?

Lecturers

Dr. Atul J. Butte

Dr. Steven A. Greenberg

Dr. Alvin Thong-Juak Kho

Dr. Peter Park

Dr. Marco F. Ramoni

Dr. Alberto A. Riva

Dr. Zoltan Szallasi

Dr. Jeffrey Mark Drazen

Dr. Todd Golub

Dr. Joel Hirschhorn

Lectures

Audio Lectures

  1. Lecture 1: Genomic Introduction Video
  2. Lecture 2: Introduction to Biology and Genomic Measurement Video
  3. Lecture 3: Measurement Techniques Video
  4. Lecture 4: Microarray - Massively Parallel Measurement Video
  5. Lecture 5: Limits of Technologies Video
  6. Lecture 6: Information Science at the Center of Genomic Medicine Video
  7. Lecture 7: Informational Resources Video
  8. Lecture 8: Complex Traits: What to Believe Video
  9. Lecture 9: Machine-learning Approach Video
  10. Lecture 10: Association with Markers Video
  11. Lecture 11: The Importance of Data Representation Video
  12. Lecture 12: Pharmacogenomics Video
  13. Lecture 13: Case Hx: Complex Traits Video
  14. Lecture 15: Microarray Disease Classification Video
  15. Lecture 16: Microarray Disease Classification II Video
  16. Lecture 17: Direct Prediction of Outcome / Mortality Video
  17. Lecture 18: Case Hx: Cancer Diagnostics Video
  18. Lecture 19: Modeling and Reverse Engineering Video
  19. Lecture 20: Practical Genomic Medicine Video

Syllabus and materials

At MIT OpenCourseWare, as the course publishes them.

Credits and licence

Institution
Massachusetts Institute of Technology
Department
Health Sciences and Technology
Teacher
Prof. Isaac Kohane
Term
Spring 2004
Level
Graduate
Language
English
Subjects
Biology, Medicine and health
Source
MIT OpenCourseWare
Licence
CC BY-NC-SA 4.0, as MIT OpenCourseWare states it. Non-commercial use only. MIT OpenCourseWare's terms
Attribution
Prof. Isaac Kohane. Genomic Medicine. Spring 2004. Massachusetts Institute of Technology: MIT OpenCourseWare, https://ocw.mit.edu/. License: Creative Commons BY-NC-SA.
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