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Course10210645640 lectures

Advances in Omics

Prof. Nagarjun Vijay · IISER Bhopal

Start with lecture 1 At NPTEL

About

The course begins with a historical perspective to genomics and how the human genome project catalyzed the development of Next-Generation sequencing technologies. Instead of following a standard textbook format of chapters, the course is designed to use the latest articles in leading journals to keep the course focused on the recent advances in the field. However, the course is well grounded in the basics and exposes the students to practical NGS data analysis. In contrast to traditional course on genomics and proteomics, this course has a strong evolutionary flavor.

Intended audience: BE/ME/MS/BSc/MSc/PhD

Prerequisites: Basics of biological molecules

Lectures

Week 1

  1. Introduction to Genomics - 1 YouTube
  2. Introduction to Genomics - 2 YouTube
  3. Advent of NGS YouTube
  4. Genome Assembly: Few Concepts and Terminology YouTube
  5. Genome Assembly Approaches YouTube

Week 2

  1. Pyrosequencing YouTube
  2. Reversible Chain Termination Based Sequencing YouTube
  3. Ph Sequencing YouTube
  4. Sequencing by Ligation (Solid) YouTube
  5. Sequencing by Ligation (Complete Genomics) YouTube

Week 3

  1. Other Short-Read Sequencing Technologies - Part-1 YouTube
  2. Other Short-Read Sequencing Technologies - Part-2 YouTube
  3. Long-Read Sequencing YouTube
  4. Single Molecule Long-Read Sequencing YouTube
  5. The Omics Data Avalanche YouTube

Week 4

  1. Evolutionary Biology & Genomics YouTube
  2. Ancient Genomics YouTube
  3. Whole-Genome Duplication YouTube
  4. Tests of Selection YouTube
  5. Genomics in Experimental Evolution YouTube

Week 5

  1. Making Sense of Genomic Sequences YouTube
  2. Transcriptomics: New Tools Leading to Deeper Insights YouTube
  3. Single Cell Transcriptomics and Beyond YouTube
  4. Proteomics: A Brief Introduction YouTube
  5. Protein Quantification YouTube

Week 6

  1. Introduction to Linux for Omics YouTube
  2. The Linux Command Line Interface YouTube
  3. Using the CLI-1:NCBI Datasets YouTube
  4. Using the CLI-2: Short Read Archive Toolkit YouTube
  5. UCSC and IGV genome browsers YouTube

Week 7

  1. Mega Omics Projects YouTube
  2. Genotype-Tissue Expression (GTEx) YouTube
  3. Encyclopedia of DNA Element (ENCODE) YouTube
  4. The Cancer Genome Atlas (TCGA) YouTube
  5. Eukaryotic Genome Sequencing Consortia YouTube

Week 8

  1. The Postomics Era YouTube
  2. RNA-Seq Differential Expression Analysis YouTube
  3. Gene Loss & its Consequences YouTube
  4. Establishing Gene loss: Few Examples YouTube
  5. Course Summary YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IISER Bhopal
Department
Biotechnology
Teacher
Prof. Nagarjun Vijay
Level
Graduate
Language
English
Subjects
Biology
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge. Coordinated by IIT Madras.
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