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Course10210675240 lectures

Cell Signaling

Prof. Ram Kumar Mishra · IISER Bhopal

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About

The course will emphasize on the fact that all living beings respond to environmental as well as cues initiated from other living organisms. Our growth (post-partum and embryonic more so) is well connected to responses we mount to the signaling. In this Course I will primarily focus on how living beings engage in signaling to stay healthy and grow normally. The focus will largely be on the receptors prevalent in the animal kingdom primarily in Mammals, but I will also introduce aspects of microbial and plant signaling events.

Prerequisites: A course in Cell Biology and Molecular Biology

Lectures

Week 1

  1. What is Signaling? YouTube
  2. Why do we need signaling? YouTube
  3. Types of Cell Signaling YouTube
  4. Signals: Nature and Composition YouTube
  5. Consequences of Signaling in context of Signal YouTube

Week 2

  1. Types of Receptors and their functioning YouTube
  2. Modes of regulation on signaling (Receptors, Signals, and Effectors) YouTube
  3. G-proteins, and Kinase activity regulation in Signaling YouTube
  4. Phosphorylation-dependent regulation in Signaling YouTube
  5. Kinase activity assessment, Types of Kinases, and Signaling system of Microbial world YouTube

Week 3

  1. Signaling by Two-component System YouTube
  2. Canonical and Hybrid Two-component system in Bacteria Life style cahnges YouTube
  3. The two-component system coordinates various microbial responses YouTube
  4. The two-component system coordinates sporulation and quorum sensing responses YouTube
  5. The two-component Signaling in plants YouTube

Week 4

  1. The Cytokinin Signaling, TCS and plant development YouTube
  2. The two-component Signaling in Ethylene, photomorphogenic, and diurnal responses YouTube
  3. Receptor Serine-Threonine Kinase Signaling YouTube
  4. Different modes of RLK Signaling in plants YouTube
  5. Receptor-Like Kinase (RLK) Signaling shaping plants YouTube

Week 5

  1. Signaling in animal world: Receptor Serine/Threonine kianse pathway YouTube
  2. Receptor Serine/Threonine kianse pathways and Bone morphogenesis YouTube
  3. Activin and AMH signaling through receptor Serine/Threonine kianse pathway YouTube
  4. Receptor Tyrosine Kinases (RTK) YouTube
  5. Activation of Receptor Tyrosine Kinases and their recognition YouTube

Week 6

  1. JAK-STAT pathway and Phosphoinositides-dependent Receptor Tyrosine Kinase Signaling YouTube
  2. Phosphoinositides-dependent Signaling downstream of RTK activation YouTube
  3. Contact-mediated bidirectional Receptor Tyrosine Kianse Signaling YouTube
  4. Contact-mediated Eph-Ephrin Signaling shapes tissue organization YouTube
  5. Contact-mediated Signaling by Notch-Delta combination YouTube

Week 7

  1. Integrin Signaling for cell motility, movement, and growth YouTube
  2. G-protein coupled receptor (GPCR): the basics and uniqueness YouTube
  3. G-protein coupled receptor mediated signaling pathways-I YouTube
  4. G-protein coupled receptor mediated signaling pathways-II YouTube
  5. G-protein coupled receptor mediated signaling pathways-III YouTube

Week 8

  1. Regulation of Signaling at receptor level YouTube
  2. Signaling by Channel-type receptors YouTube
  3. Water Channels and nuclear/cytosolic receptors YouTube
  4. Nuclear receptors with TF activity, and signaling co-receptors YouTube
  5. A Snapshot and brief summary of the Cell Signaling YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IISER Bhopal
Department
Biotechnology
Teacher
Prof. Ram Kumar Mishra
Level
Graduate
Language
English
Subjects
Biology
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge. Coordinated by IIT Madras.
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