Course10210600240 lectures
Evolution in the Genomic Era
Prof. Nagarjun Vijay · IISER Bhopal
About
The course begins with a historical perspective to evolution and the important personalities that shaped early ideas. Prominent examples and events that laid the foundation of evolutionary biology are discussed. The next section covers the theory proposed by Darwin and its historical context. Importantly, the contributions of other contemporaries such as Wallace are also discussed. The rediscovery of the works of Mendel and the ensuing debates to reconcile evolution with the concept of particulate inheritance are covered with historical examples. The third week ends by looking at the impact of the genomics era. The subsequent weeks introduce some core concepts in evolutionary biology and the link between genotype & phenotype. Demonstrations will introduce the students to the use of computational tools.
Intended audience: BE/ME/MS/BSc/MSc/PhD
Prerequisites: Basics of biological molecules, Zoology, Botany
Lectures
Week 1
- Introduction to Evolutionary Genomics
- Proto-Evolutionary Thought and Early Foundations
- From Fixity to Mutability, Deep Time, and Fossils
- Pre-Darwinian Evolution: Buffon, Lamarck, Egypt, and Cuvier
- Before Darwin I: Ibis, Uniformitarianism, Catastrophism, Lyell, and Embryology
- Before Darwin II: Voyages, Biogeography, Malthus, Vestiges, and Convergence
Week 2
- Darwin’s Beagle Voyage: Biogeography, Fossils, and Natural Selection
- Darwin’s Island Laboratories, Tree of Life, and Natural Selection
- Darwin’s Origin of Species: Structure and Four Principles
- Wallace, Natural Selection, and Darwin’s Broader Legacy
- Darwin’s Reception: Jenkin’s Critique, Inheritance, and Modern Synthesis
Week 3
- Modern Synthesis I: Inheritance, Traits, Mutationism, and Gradualism
- Modern Synthesis II: Microevolution, Macroevolution, Species, and Adaptation
- Beyond Modern Synthesis I: Evo-Devo, Neutral Theory, Clocks, Punctuated Equilibrium
- Beyond Modern Synthesis II: EES, Niche Construction, Selection, and Transitions
- Applications of Evolutionary Genomics
Week 4
- Reintroducing Evolution: Evidence, Trees, and Four Evolutionary Forces
- Adaptive Evolution: Selection, Fitness, and Limits of Adaptation
- Neutral Evolution: Drift, Bottlenecks, Founder Effects, and Selection Signatures
- Sexual Selection: Competition, Choice, Post-Mating Selection, and Dimorphism
- Evolutionary Contingency: Mutations and Fitness Effects
Week 5
- Model Organisms, Sticklebacks, HWE, and Deviations
- Undertanding Deterministic Selection and Drift with Evidence
- HWE Deviations: Migration, Recombination, LD, and Adaptive Architecture
- Genotype to Phenotype: Trait Architecture and Evolutionary Forces
- Speciation: From Population Divergence to New Species
Week 6
- From Morphology to Molecular Phylogenetics
- Genetic Markers – Choosing the Right Molecular Lens
- From Phylogenetics to Phylogenomics: Trees and Discordance
- Substrates for Evolution I: Gene Content, Structural Variation, and Phylogenomics
- Substrates for Evolution II: Regulation, Gene Expression, Genomes, and Phenotypes
Week 7
- Molecular Signatures of Selection from Sequence Evolution
- Molecular Tests of Selection: dN/dS Analysis
- Beyond dN/dS: McDonald-Kreitman Test and Adaptive Evolution
- Beyond dN/dS: Lineage Selection, Convergence, and Gene Loss
Week 8
Syllabus and materials
At NPTEL, as the course publishes them.
Credits and licence
- Institution
- IISER Bhopal
- Department
- Biotechnology
- Teacher
- Prof. Nagarjun Vijay
- Level
- Graduate
- Language
- English
- Subjects
- Biology
- Source
- NPTEL
- Licence
- CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
- Attribution
- NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge. Coordinated by IIT Madras.
- Who can watch
- NPTEL gives no rating. Invisible Network shows it to Tweens profiles and older, judged from what the source says about it. How courses are placed
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