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Course10210105840 lectures

Introduction to Mechanobiology

Prof. Shamik Sen · IIT Bombay

Start with lecture 1 At NPTEL

About

Mechanobiology is an upcoming interdisciplinary field of science where concepts of mechanics, biology and engineering are combined to understand the basics of different cellular processes ranging from cell division to cell differentiation and death.

Intended audience: Biotech/Biosciences/Bioengineering/Physics/Mechanical Engineering/Chemical Engineering

Prerequisites: B.Sc/B. Tech: Biotech/Biosciences/Bioengineering MSc/M.Tech: Biotech/Biosciences/Bioengineering

Lectures

Week 1

  1. Lecture 1: Need to Study Mechanobiology YouTube
  2. Lecture 2: Cell as a Tent, Individual Components YouTube
  3. Lecture 3 : Cell-ECM Crosstalk YouTube
  4. Lecture 4 : ECM Proteins: Collagen YouTube
  5. Lecture 5 : Measuring Properties of Collagen Networks YouTube

Week 2

  1. Lecture 6 : Properties of Collagen Networks YouTube
  2. Lecture 7 : Rheology YouTube
  3. Lecture 8 : Rheology of Biopolymer Networks YouTube
  4. Lecture 9 : Atomic Force Microscopy (AFM) YouTube
  5. Lecture 10 : Design of Protein Constructs for AFM YouTube

Week 3

  1. Lecture 11 : Protein Unfolding using AFM YouTube
  2. Lecture 12 : Protein Unfolding using AFM YouTube
  3. Lecture 13 : Focal Adhesions: Focal Adhesion Proteins YouTube
  4. Lecture 14 : Focal Adhesion Organization YouTube
  5. Lecture 15 : Focal Adhesions: Role of Forces YouTube

Week 4

  1. Lecture 16 : Cytoskeleton: Actin YouTube
  2. Lecture 17 : Force-velocity Relationships of Actin Networks YouTube
  3. Lecture 18 : Mesenchymal Cell Migration YouTube
  4. Lecture 19 : Actin Dynamics during Mesenchymal Migration YouTube
  5. Lecture 20 : Actin Dynamics during Mesenchymal Migration YouTube

Week 5

  1. Lecture 21 : Adhesion Independent Migration YouTube
  2. Lecture 22 : Adhesion Independent & Collective Cell Migration YouTube
  3. Lecture 23 : Collective Cell Migration YouTube
  4. Lecture 24 : Mechanobiology of Stem Cell Fate - I YouTube
  5. Lecture 25 : Mechanobiology of Stem Cell Fate - II YouTube

Week 6

  1. Lecture 26 : Mechanobiology of Stem Cell Fate – III YouTube
  2. Lecture 27 : Mechanobiology of Diseases: Cancer I YouTube
  3. Lecture 28 : Mechanobiology of Diseases: Cancer II YouTube
  4. Lecture 29 : Mechanobiology of Diseases: Cancer III YouTube
  5. Lecture 30 : Mechanobiology of Diseases: Atherosclerosis & Hypertension YouTube

Week 7

  1. Lecture 31 : Mechanobiology of Diseases: Muscular Dystrophy YouTube
  2. Lecture 32 : Nuclear Mechanotransduction: LINC complex YouTube
  3. Lecture 33 : Nuclear Mechanotransduction: LINC Complex in Cell Migration YouTube
  4. Lecture 34 : Nuclear Mechanotransduction: Gene Regulation YouTube
  5. Lecture 35 : Mechanical Forces & DNA damage YouTube

Week 8

  1. Lecture 36 : Techniques in Mechanobiology: Hydrogels YouTube
  2. Lecture 37 : Techniques in Mechanobiology: AFM YouTube
  3. Lecture 38 : Techniques in Mechanobiology: Traction Force Microscopy, Trypson Deadhesion & Laser Ablation YouTube
  4. Lecture 39 : Techniques in Mechanobiology: Microfabrication YouTube
  5. Lecture 40 : Techniques in Mechanobiology: FRET YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Bombay
Department
Biotechnology
Teacher
Prof. Shamik Sen
Level
Undergraduate
Language
English
Subjects
Biology
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
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