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CourseCHEM 125a37 lectures

Freshman Organic Chemistry I

J. Michael McBride · Yale University

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About

This is the first semester in a two-semester introductory course focused on current theories of structure and mechanism in organic chemistry, their historical development, and their basis in experimental observation. The course is open to freshmen with excellent preparation in chemistry and physics, and it aims to develop both taste for original science and intellectual skills necessary for creative research.

Lectures

  1. How Do You Know? Lecture 1 · Audio
  2. Force Laws, Lewis Structures and Resonance Lecture 2 · Audio
  3. Double Minima, Earnshaw's Theorem and Plum-Puddings Lecture 3 · Audio
  4. Coping with Smallness and Scanning Probe Microscopy Lecture 4 · Audio
  5. X-Ray Diffraction Lecture 5 · Audio
  6. Seeing Bonds by Electron Difference Density Lecture 6 · Audio
  7. Quantum Mechanical Kinetic Energy Lecture 7 · Audio
  8. One-Dimensional Wave Functions Lecture 8 · Audio
  9. Chladni Figures and One-Electron Atoms Lecture 9 · Audio
  10. Reality and the Orbital Approximation Lecture 10 · Audio
  11. Orbital Correction and Plum-Pudding Molecules Lecture 11 · Audio
  12. Overlap and Atom-Pair Bonds Lecture 12 · Audio
  13. Overlap and Energy-Match Lecture 13 · Audio
  14. Checking Hybridization Theory with XH3 Lecture 14 · Audio
  15. Chemical Reactivity: SOMO, HOMO, and LUMO Lecture 15 · Audio
  16. Recognizing Functional Groups Lecture 16 · Audio
  17. Reaction Analogies and Carbonyl Reactivity Lecture 17 · Audio
  18. Amide, Carboxylic Acid and Alkyl Lithium Lecture 18 · Audio
  19. Oxygen and the Chemical Revolution (Beginning to 1789) Lecture 19 · Audio
  20. Rise of the Atomic Theory (1790-1805) Lecture 20 · Audio
  21. Berzelius to Liebig and Wöhler (1805-1832) Lecture 21 · Audio
  22. Radical and Type Theories (1832-1850) Lecture 22 · Audio
  23. Valence Theory and Constitutional Structure (1858) Lecture 23 · Audio
  24. Determining Chemical Structure by Isomer Counting (1869) Lecture 24 · Audio
  25. Models in 3D Space (1869-1877); Optical Isomers Lecture 25 · Audio
  26. Van't Hoff's Tetrahedral Carbon and Chirality Lecture 26 · Audio
  27. Communicating Molecular Structure in Diagrams and Words Lecture 27 · Audio
  28. Stereochemical Nomenclature; Racemization and Resolution Lecture 28 · Audio
  29. Preparing Single Enantiomers and the Mechanism of Optical Rotation Lecture 29 · Audio
  30. Esomeprazole as an Example of Drug Testing and Usage Lecture 30 · Audio
  31. Preparing Single Enantiomers and Conformational Energy Lecture 31 · Audio
  32. Stereotopicity and Baeyer Strain Theory Lecture 32 · Audio
  33. Conformational Energy and Molecular Mechanics Lecture 33 · Audio
  34. Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes Lecture 34 · Audio
  35. Understanding Molecular Structure and Energy through Standard Bonds Lecture 35 · Audio
  36. Bond Energies, the Boltzmann Factor and Entropy Lecture 36 · Audio
  37. Potential Energy Surfaces, Transition State Theory and Reaction Mechanism Lecture 37 · Audio

Syllabus and materials

At Open Yale Courses, as the course publishes them.

Credits and licence

Institution
Yale University
Department
Chemistry
Teacher
J. Michael McBride
Term
Fall 2008
Level
Undergraduate
Language
English
Subjects
Chemistry
Source
Open Yale Courses
Licence
CC BY-NC-SA 3.0 US, as Open Yale Courses states it. Non-commercial use only. Open Yale Courses's terms
Attribution
Open Yale Courses, Yale University. Licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 licence; third-party material in the lectures is not.
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