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CourseCHEM 125b38 lectures

Freshman Organic Chemistry II

J. Michael McBride · Yale University

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About

This is a continuation of Freshman Organic Chemistry I (CHEM 125a), the introductory course on current theories of structure and mechanism in organic chemistry for students with excellent preparation in chemistry and physics. This semester treats simple and complex reaction mechanisms, spectroscopy, organic synthesis, and some molecules of nature.

Lectures

  1. Mechanism: How Energies and Kinetic Order Influence Reaction Rates Lecture 1 · Audio
  2. Peculiar Rate Laws, Bond Dissociation Energies, and Relative Reactivities Lecture 2 · Audio
  3. Rate and Selectivity in Radical-Chain Reactions Lecture 3 · Audio
  4. Electronegativity, Bond Strength, Electrostatics, and Non-Bonded Interactions Lecture 4 · Audio
  5. Solvation, H-Bonding, and Ionophores Lecture 5 · Audio
  6. Brønsted Acidity and the Generality of Nucleophilic Substitution Lecture 6 · Audio
  7. Nucleophilic Substitution Tools - Stereochemistry, Rate Law, Substrate, Nucleophile, Leaving Group Lecture 7 · Audio
  8. Solvent, Leaving Group, Bridgehead Substitution, and Pentavalent Carbon Lecture 8 · Audio
  9. Pentavalent Carbon? E2, SN1, E1 Lecture 9 · Audio
  10. Cation Intermediates – Alkenes: Formation, Addition, and Stability Lecture 10 · Audio
  11. Carbocations and the Mechanism of Electrophilic Addition to Alkenes and Alkynes Lecture 11 · Audio
  12. Nucleophilic Participation During Electrophilic Addition to Alkenes: Halogen, Carbene, and Borane Lecture 12 · Audio
  13. Addition to Form Three-Membered Rings: Carbenoids and Epoxidation Lecture 13 · Audio
  14. Epoxide Opening, Dipolar Cycloaddition, and Ozonolysis Lecture 14 · Audio
  15. Metals and Catalysis in Alkene Oxidation, Hydrogenation, Metathesis, and Polymerization Lecture 15 · Audio
  16. Isoprenoids, Rubber, and Tuning Polymer Properties Lecture 16 · Audio
  17. Alkynes; Conjugation in Allylic Intermediates and Dienes Lecture 17 · Audio
  18. Linear and Cyclic Conjugation Theory; 4n+2 Aromaticity Lecture 18 · Audio
  19. Aromatic Transition States: Cycloaddition and Electrocyclic Reactions Lecture 19 · Audio
  20. Electronic and Vibrational Spectroscopy Lecture 20 · Audio
  21. Functional Groups and Fingerprints in IR Spectroscopy; Precession of Magnetic Nuclei Lecture 21 · Audio
  22. Medical MRI and Chemical NMR Lecture 22 · Audio
  23. Diamagnetic Anisotropy and Spin-Spin Splitting Lecture 23 · Audio
  24. Higher-Order Effects, Dynamics, and the NMR Time Scale Lecture 24 · Audio
  25. C-13 and 2D NMR – Electrophilic Aromatic Substitution Lecture 25 · Audio
  26. Aromatic Substitution in Synthesis: Friedel-Crafts and Moses Gomberg Lecture 26 · Audio
  27. Triphenylmethyl and an Introduction to Carbonyl Chemistry Lecture 27 · Audio
  28. Mechanism and Equilibrium of Carbonyl Reactions Lecture 28 · Audio
  29. Imines and Enamines; Oxidation and Reduction Lecture 29 · Audio
  30. Oxidation States and Mechanisms Lecture 30 · Audio
  31. Periodate Cleavage, Retrosynthesis, and Green Chemistry Lecture 31 · Audio
  32. Measuring Bond Energies: Guest Lecture by Prof. G. Barney Ellison Lecture 32 · Audio
  33. Green Chemistry; Acids and Acid Derivatives Lecture 33 · Audio
  34. Acids and Acid Derivatives Lecture 34 · Audio
  35. Acyl Insertions and α-Reactivity Lecture 35 · Audio
  36. α-Reactivity and Condensation Reactions Lecture 36 · Audio
  37. Proving the Configuration of Glucose and Synthesizing Two Unnatural Products Lecture 37 · Audio
  38. Review: Synthesis of Cortisone Lecture 38 · Audio

Syllabus and materials

At Open Yale Courses, as the course publishes them.

Credits and licence

Institution
Yale University
Department
Chemistry
Teacher
J. Michael McBride
Term
Spring 2011
Level
Undergraduate
Language
English
Subjects
Chemistry
Source
Open Yale Courses
Licence
CC BY-NC-SA 3.0 US, as Open Yale Courses states it. Non-commercial use only. Open Yale Courses's terms
Attribution
Open Yale Courses, Yale University. Licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 licence; third-party material in the lectures is not.
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