Learn · Mass Spectrometry and its application in Molecular Medicine
Lecture 55 of 60Week 11
Imaging of kidney tissues of NP exposed rats and imaging of human prostate tissue
Prof. Amit Kumar Mandal · IISER Kolkata
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- Mass Spectrometry and its application in Molecular Medicine, IISER Kolkata (at NPTEL)
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All the lectures
- Introduction to soft ionisation mass spectrometry: ESI-MS and MALDI-MS
- Isotopic distribution of signals in mass spectra and deconvolution of mass spectra
- Resolution of mass spectra, accuracy in mass measurement and introduction of molecular medicine
- Mass spectra of human hemoglobin and glycated hemoglobin, a diagnostic marker of diabetes mellitus and glutathionyl hemoglobin, a marker of oxidative stress
- Mass spectrometry based quantification of oxidative stress in patients with chronic renal failure
- Introduction to tandem mass spectrometry and principle of de novo sequencing
- Chemical modification and enzyme digestion of a peptide: A step towards de novo sequencing
- De novo sequencing of a peptide from chemical derivatization and tandem mass spectra
- De novo sequencing: Identification of isobaric amino acid and disulfide connectivity
- De novo sequencing of a tryptic peptide from tandem mass spectra
- De novo sequencing from tandem-MS and SPITC derivatization to simplify tandem-MS
- Routine diagnosis of Hemoglobinopathy: A disease caused by genetic variant of hemoglobin
- Hemoglobinopathies: Identification and characterisation using bottom up proteomics approach--Part-1
- Hemoglobinopathies: Identification and characterisation using bottom up proteomics approach--Part-2
- A genetic variant of hemoglobin causing false elevation of HbA1c and hence false diagnosis of diabetes mellitus
- Nano-LC-ESI-MS based analysis of a proteome - A bottom up proteomics approach
- Iron salts as food fortificants to combat Iron Deficiency Anemia
- Nano ferric pyrophosphate as a food fortificant in a rat model: Bioavailability and toxicity assessment
- Nano ferric pyrophosphate as a food fortificant in a rat model: Toxicity assessment using biochemical, histopathological and proteomics approach
- Nano ferric pyrophosphate as a food fortificant in a rat model: Exploring biomarker of nano particle induced toxicity in rat plasma
- Biomarker of nano particles induced toxicity in a rat model: NanoLC-ESI-MS based plasma proteomics approach
- Quantitative proteomics of rat plasma proteins: Absolute quantification of Fetuin B, a biomarker of nano particle toxicity
- 2D gel electrophoresis based proteomics: principles and methods
- Differential plasma proteomics: 2D gel electrophoresis based approach
- Analysis of 2D gel spots followed by in-gel digestion to identify proteins usng MALDI-MS platform
- Mass spectrometry based absolute quantification of human plasma proteins
- Absolute quantification of plasma Apolipoprotein-AIV: A probale biomarker of attempted suicide
- MALDI-MS based identification of microorganism in clinical samples
- Native mass spectrometry using nano-ESI-MS platform
- Analysis of an array of glycated hemoglobin in patients with poorly controlled diabetes mellitus
- Molecular mechanism of sickle hemoglobin polymerisation
- Inhibition of sickle hemoglobin polymerisation upon glutathionylation
- Structural analysis of desorbed hemoglobin from nano particle surface
- Functional assay of human hemoglobin and its variants
- Application of native mas spectrometry to calculate equilibrium constant
- Bioconjugation of para-benzoquinone of cigarette smoke with human hemoglobin
- Bioconjugation of human hemoglobin with quinone as airborne enviroment pollutants
- Ion mobility mass spectrometry
- Introduction to hydrogen-deuterium-exchange mass spectrometry
- Rate law of hydrogen-deuterium-exchange kinetics
- Molecular insights in inhibition of HbS polymerisation upon oxygenation monitored by HDX-MS platform-part-I
- Molecular insights in inhibition of HbS polymerisation upon oxygenation monitored by HDX-MS platform-part-II
- Molecular insights in inhibition of HbS polymerisation upon oxygenation -part-III- and upon glutathionylation-part-I-monitored by HDX-MS platform
- Molecular insights in inhibition of HbS polymerisation upon glutathionylation-part-II
- N-acetyl cysteine as an antisickling agent in sickle cell disease
- Effect of quinones on morphology of human RBC
- Effect-of-NAC-to neturalise-quinone-and-in-vivo-HDX with human RBCs as a model system
- Application of HDX-MS in structural analysis of human hemoglobin in vivo
- Application of HDX-MS in structural analysis of hemoglobin in vivo-and-desorbed-hemoglobin from nano particle-surface
- Application-of-HDX-MS-and -CD-spectroscopy-to-monitor-structural changes-of human hemoglobin from nano particle surface
- Structure-function correlation of Hb Beckman, a genetic variant of human hemoglobin, using HDX-MS
- Structure-function correlation of glutathionyl hemoglobin, a posttranslational variant of human hemoglobin, using HDX-MS
- Imaging mass spectromery of biological tissue samples using MALDI mass spectrometry platform
- Kidney tissue imaging in a nano particle exposed rat model
- Imaging of kidney tissues of NP exposed rats and imaging of human prostate tissue
- Imaging of human prostate cancer tissue using MALDI-MS
- Imaging of human prostate cancer tissue using MALDI-MS and analysis of tissue proteomics data
- Desorption Electrospary Ionisation based Mass Spectrometric Imaging of Prostate Cancer Tissue
- Fast photochemical oxidation of protein combined to mass spectrometry for prtein footprinting both in vitro and in vivo
- Biosimilar-monitored through mass spectrometric techniques