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Course102106345156 lectures

Classics in Neuroscience

Prof. Varadhan SKM · IIT Madras

Start with lecture 1 At NPTEL

Lectures

week-01

  1. History of Neuroscience - Introduction: Part 1 Video
  2. History of Neuroscience - Introduction: Part 2 Video
  3. Factors that produce discoveries Video
  4. Importance of the 1950s in Neuroscience Video
  5. Advances in Molecular Biology (Genes to DNA) Video
  6. Discovery of the structure of the DNA Video
  7. How DNA works Video
  8. Molecular biology of the human brain Video

week-02

  1. Signaling molecule: The First growth Factor Video
  2. Nerve Growth Factor Video
  3. Organizing the Connections Video
  4. Axonal Transport Video
  5. Signaling molecules: The First Neurotransmitter in the brain Video
  6. The concept of Lock and Key Video
  7. The Soup vs Sparks Debate Video
  8. Intracellular Electrode, Neurotransmitter in the Brain, Dales Law Video
  9. Early evidence of Acetylcholine and Glutamate Video
  10. Early evidence of GABA and Serotonin Video
  11. Catecholamine and Hormones Video
  12. Second messengers and Hormones Video
  13. Pheromones Video

week-03

  1. Revolution in Cytology Video
  2. Synapse and the 'Neuronism vs Reticularism' debate Video
  3. Contributions by Rene Couteaux and George Koelle Video
  4. Chemical Synapse Video
  5. Synapse and the Neuromuscular Junction Video
  6. The Electrical Synapse and Myelin Video
  7. Physiology: The Action Potential - Part 1 Video
  8. Recording nerve impulses and single action potentials Video
  9. Recording from nerve and plant cells Video
  10. Recording Local circuits, Hodgkin and Huxely contributions - Part 1 Video
  11. Hodgkin and Huxely model - part 2 & Kenneth Cole Contributions Video
  12. GHK equation and HH action potentials Video

week-04

  1. First Electrophysiological Evidence for Synaptic Transmission Video
  2. Bernard Katz Video
  3. End-Plate Potential and Synaptic Quanta Video
  4. Eccles and Spinal motor neuron Video
  5. Invertebrate simple systems: Aplysia Video
  6. Other studies of sensory responses Video
  7. Legacy of Golgi and Ramo`n y Cajal Video
  8. Dynamic polarization of Neuron Video
  9. Modern Research Video
  10. Synaptic Integration and Action Potential Initiation Video
  11. Active properties of dendrites Video
  12. Dendritic dominance Video
  13. Dendritic spines Video
  14. Rethinking the concept of Neuron Doctrine Video

week-05

  1. Muscle spindles Video
  2. Spinal cord pathways Video
  3. Retinal Processing Video
  4. Keffler Hartline Video
  5. Stephen Kuffler and Horace Barlow Video
  6. Expansion of the Reflex concept Video
  7. Central Pttern genrators Video
  8. The cortical column Video
  9. Vernon Mountcastle Video
  10. Central Visual Processing Video
  11. Central Visual Processing and Feature Detectors Video
  12. Intracellular recordings from the brain - Part 1 Video
  13. Intracellular recordings from the brain - Part 2 Video
  14. Two motor systems Video
  15. Auditory cortex and The pattern theory of olfaction Video

week-06

  1. Arousal and Reticular activating system Video
  2. Sleep and Rapid Eye Movements Video
  3. Operant Conditioning by brain stimulation Video
  4. Hypothalamus and Feeding Behavior Video
  5. Brain as a gland Video
  6. Hypothalamic-Neurohypophyseal System Video
  7. Hypothalamic-Adenohypophyseal System Video
  8. Founding Modern Neuroanatomy Video
  9. Psychology and Ethology Video
  10. Karl Lashley Video
  11. Donald Hebb Video
  12. Limbic system- Limbic Lobe and Papez Circuit Video
  13. Limbic system-Kluver-Bucy Syndrome Video
  14. The Limbic system & Amygdala Video
  15. The Hippocampus and Patient H.M Video
  16. Brenda Milner Video

week-07

  1. Neurology: Foundations of Brain Imaging Video
  2. The Neurological unit of the Boston City Hospital Video
  3. Derek Denny-Brown, Raymond Adams and C. Miller Fisher Video
  4. Montreal Neurological Institute Video
  5. Cerebral Circulation Video
  6. Spreading depression of Leo and Migraine Video
  7. The Eradication of Polio Video
  8. Origin of Neurosurgery Video
  9. Harvey Cushing Video
  10. Pituitary Surgery Video
  11. Stereotaxy Video
  12. Epilepsy Video
  13. Psychosurgery Video

week-08

  1. Antipsychotic Drugs Video
  2. Reserpine Video
  3. Monoamine Oxidase Inhibitors Video
  4. Lithium Video
  5. Benzodiazepines Video
  6. Stress Video
  7. Theoretical Neuroscience: Brain as computer and Computer as Brain Video
  8. John Atanasoff Video
  9. John von Newmann Video
  10. Game and Information theory Video
  11. Cybernetics and Artificial Intelligence Video
  12. Towards Networks of Realistic Neurons: von Newman's Last word Video

week-09

  1. Santiago Ramon y Cajal, "The Peasant Genius" Video
  2. "Cajal- a giant wakes up" Video
  3. Cajal's modifications to the Golgi method and studies of embryos and various systems Video
  4. Law of dynamic polarization, support from others studies Video
  5. Santiago Ramon y Cajal - Career turning point and Palm Sunday years Video
  6. Cajal’s trailblazing discoveries that earned him the Nobel Prize Video
  7. "Enduring Legacy of Cajal" Video
  8. Robert Barany - Early life and prior work done by other scientists Video
  9. Robert Barany - The serendipitous discovery of the caloric test Video
  10. Robert Barany - Vestibular System and connection to Cerebellum Video
  11. Robert Barany - Modern Applications of Barany's work - Space medicine and Astronaut training Video
  12. Robert Barany - Summary of Contributions Video

week-10

  1. Charles Sherrington Personal Background Video
  2. Charles Sherrington - quiet mind expt, Neuroplasiticity, animal locomotion studies Video
  3. Charles Sherrington - Reciprocal innervation, Pain & Emotion, Mind & Body Video
  4. Charles Sherrington's Magnum Opus - The integrative action of the nervous system Video
  5. Charles Sherrington - Insights into life and work by Molnar & Brown Video
  6. Charles Sherrington - Summary of contributions Video
  7. Edgar Adrian, Keith Lucas and Novel instruments used in Neurophysiology Video
  8. Edgar Adrian - Early life, All or none principle in neurons, Key findings with Keith Lucas Video
  9. Edgar Adrian - Work with Alexander Forbes, Gasser & Erlanger (St. Louis connection) Video
  10. Edgar Adrian - "Failed experiment", Perseverance in science Video
  11. Edgar Adrian - Recording from single sensory and motor neurons Video
  12. Edgar Adrian - Nobel Prize, Admin work, Legacy Video
  13. Edgar Adrian - Adventures with EEG Video
  14. Edgar Adrian - Mapping cerebellar cortex, Cerebral cortex, Brain & Behavior, Olfaction Video
  15. Hodgkin & Huxley - Biographical background, Scientific backdrop and state of Neurophysiology Video
  16. Hodgkin & Huxley - Meeting of great minds & Challenges faced - Part 01 Video
  17. Hodgkin & Huxley - Meeting of great minds & Challenges faced - Part 02 Video

week-11

  1. Bernard Katz - personal background, scientific backdrop, soup vs spark debate Video
  2. Bernard Katz - Quantal nature of synaptic transmission, Vesicle hypothesis, foundational work Video
  3. Bernard Katz - del Castillo model of receptor activation, role of calcium in synapses, sodium Video
  4. Bernard Katz Paper: The fine structure of neuromuscular junction of the frog Video
  5. Roger Sperry - Personal Background, Split brain patients, Hemispheric specialization Video
  6. Roger Sperry: Split Brain patients and Dichotomous consciousness Video
  7. Roger Sperry: Unified consciousness & Behavioural differences in split brain patients, Video
  8. Roger Sperry, Gazzaniga's Interpreter theory, Impact on Psychology and Neuroscience, Nobel Prize Video
  9. Roger Sperry's Chemoaffinity hypothesis paper Video
  10. Roger Sperry paper "Mentalism: Yes, Dualism:No" Video

week-12

  1. Jens Christian Skou Part 1 :The Story of Jens Christian Skou's life in science Video
  2. Jens Christian Skou: Sodium Potassium pump overview & Nobel Prize Video
  3. Jens Christian Skou: Paper- "The Influence of Some Cations on an Adenosine Triphosphate Video
  4. Arvid Carlsson - Personal Background, Education & Early Career, Pivot, Nobel prize contributions Video
  5. Arvid Carlsson: History of L Dopa Video
  6. Arvid Carlsson - Antipsychotics, Dopamine hypothesis, Serotonin and SSRIs, Omeprazole Video
  7. Eric Kandel - Early life and nobel prize winning work Video
  8. Eric Kandel - Synaptic Plasticity Video
  9. Eric Kandel - Aplysia work, Short and long term memory & mechanisms Video
  10. Paul Greengard - The Phosphorylation Paradigm Video
  11. David Hubel & Torsten Wiesel - early life, education and collaboration Video
  12. Hubel & Wiesel - Effect of early visual deprivation on cortical function Video
  13. Hubel & Wiesel: Effect of visual misalignment on binocular integration Video
  14. Hubel & Wiesel: Limited capacity for recovery following early visual deprivation Video

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Madras
Department
Biotechnology
Teacher
Prof. Varadhan SKM
Level
Undergraduate
Language
English
Subjects
Biology
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
Who can watch
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