Learn · Classics in Neuroscience
Lecture 24 of 156week-03
Contributions by Rene Couteaux and George Koelle
Prof. Varadhan SKM · IIT Madras
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- Classics in Neuroscience, IIT Madras (at NPTEL)
- Licence
- CC BY-NC-SA, as NPTEL states it. Non-commercial use only.
- Attribution
- NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
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- Teens profiles and older. How courses are placed
All the lectures
- History of Neuroscience - Introduction: Part 1
- History of Neuroscience - Introduction: Part 2
- Factors that produce discoveries
- Importance of the 1950s in Neuroscience
- Advances in Molecular Biology (Genes to DNA)
- Discovery of the structure of the DNA
- How DNA works
- Molecular biology of the human brain
- Signaling molecule: The First growth Factor
- Nerve Growth Factor
- Organizing the Connections
- Axonal Transport
- Signaling molecules: The First Neurotransmitter in the brain
- The concept of Lock and Key
- The Soup vs Sparks Debate
- Intracellular Electrode, Neurotransmitter in the Brain, Dales Law
- Early evidence of Acetylcholine and Glutamate
- Early evidence of GABA and Serotonin
- Catecholamine and Hormones
- Second messengers and Hormones
- Pheromones
- Revolution in Cytology
- Synapse and the 'Neuronism vs Reticularism' debate
- Contributions by Rene Couteaux and George Koelle
- Chemical Synapse
- Synapse and the Neuromuscular Junction
- The Electrical Synapse and Myelin
- Physiology: The Action Potential - Part 1
- Recording nerve impulses and single action potentials
- Recording from nerve and plant cells
- Recording Local circuits, Hodgkin and Huxely contributions - Part 1
- Hodgkin and Huxely model - part 2 & Kenneth Cole Contributions
- GHK equation and HH action potentials
- First Electrophysiological Evidence for Synaptic Transmission
- Bernard Katz
- End-Plate Potential and Synaptic Quanta
- Eccles and Spinal motor neuron
- Invertebrate simple systems: Aplysia
- Other studies of sensory responses
- Legacy of Golgi and Ramo`n y Cajal
- Dynamic polarization of Neuron
- Modern Research
- Synaptic Integration and Action Potential Initiation
- Active properties of dendrites
- Dendritic dominance
- Dendritic spines
- Rethinking the concept of Neuron Doctrine
- Muscle spindles
- Spinal cord pathways
- Retinal Processing
- Keffler Hartline
- Stephen Kuffler and Horace Barlow
- Expansion of the Reflex concept
- Central Pttern genrators
- The cortical column
- Vernon Mountcastle
- Central Visual Processing
- Central Visual Processing and Feature Detectors
- Intracellular recordings from the brain - Part 1
- Intracellular recordings from the brain - Part 2
- Two motor systems
- Auditory cortex and The pattern theory of olfaction
- Arousal and Reticular activating system
- Sleep and Rapid Eye Movements
- Operant Conditioning by brain stimulation
- Hypothalamus and Feeding Behavior
- Brain as a gland
- Hypothalamic-Neurohypophyseal System
- Hypothalamic-Adenohypophyseal System
- Founding Modern Neuroanatomy
- Psychology and Ethology
- Karl Lashley
- Donald Hebb
- Limbic system- Limbic Lobe and Papez Circuit
- Limbic system-Kluver-Bucy Syndrome
- The Limbic system & Amygdala
- The Hippocampus and Patient H.M
- Brenda Milner
- Neurology: Foundations of Brain Imaging
- The Neurological unit of the Boston City Hospital
- Derek Denny-Brown, Raymond Adams and C. Miller Fisher
- Montreal Neurological Institute
- Cerebral Circulation
- Spreading depression of Leo and Migraine
- The Eradication of Polio
- Origin of Neurosurgery
- Harvey Cushing
- Pituitary Surgery
- Stereotaxy
- Epilepsy
- Psychosurgery
- Antipsychotic Drugs
- Reserpine
- Monoamine Oxidase Inhibitors
- Lithium
- Benzodiazepines
- Stress
- Theoretical Neuroscience: Brain as computer and Computer as Brain
- John Atanasoff
- John von Newmann
- Game and Information theory
- Cybernetics and Artificial Intelligence
- Towards Networks of Realistic Neurons: von Newman's Last word
- Santiago Ramon y Cajal, "The Peasant Genius"
- "Cajal- a giant wakes up"
- Cajal's modifications to the Golgi method and studies of embryos and various systems
- Law of dynamic polarization, support from others studies
- Santiago Ramon y Cajal - Career turning point and Palm Sunday years
- Cajal’s trailblazing discoveries that earned him the Nobel Prize
- "Enduring Legacy of Cajal"
- Robert Barany - Early life and prior work done by other scientists
- Robert Barany - The serendipitous discovery of the caloric test
- Robert Barany - Vestibular System and connection to Cerebellum
- Robert Barany - Modern Applications of Barany's work - Space medicine and Astronaut training
- Robert Barany - Summary of Contributions
- Charles Sherrington Personal Background
- Charles Sherrington - quiet mind expt, Neuroplasiticity, animal locomotion studies
- Charles Sherrington - Reciprocal innervation, Pain & Emotion, Mind & Body
- Charles Sherrington's Magnum Opus - The integrative action of the nervous system
- Charles Sherrington - Insights into life and work by Molnar & Brown
- Charles Sherrington - Summary of contributions
- Edgar Adrian, Keith Lucas and Novel instruments used in Neurophysiology
- Edgar Adrian - Early life, All or none principle in neurons, Key findings with Keith Lucas
- Edgar Adrian - Work with Alexander Forbes, Gasser & Erlanger (St. Louis connection)
- Edgar Adrian - "Failed experiment", Perseverance in science
- Edgar Adrian - Recording from single sensory and motor neurons
- Edgar Adrian - Nobel Prize, Admin work, Legacy
- Edgar Adrian - Adventures with EEG
- Edgar Adrian - Mapping cerebellar cortex, Cerebral cortex, Brain & Behavior, Olfaction
- Hodgkin & Huxley - Biographical background, Scientific backdrop and state of Neurophysiology
- Hodgkin & Huxley - Meeting of great minds & Challenges faced - Part 01
- Hodgkin & Huxley - Meeting of great minds & Challenges faced - Part 02
- Bernard Katz - personal background, scientific backdrop, soup vs spark debate
- Bernard Katz - Quantal nature of synaptic transmission, Vesicle hypothesis, foundational work
- Bernard Katz - del Castillo model of receptor activation, role of calcium in synapses, sodium
- Bernard Katz Paper: The fine structure of neuromuscular junction of the frog
- Roger Sperry - Personal Background, Split brain patients, Hemispheric specialization
- Roger Sperry: Split Brain patients and Dichotomous consciousness
- Roger Sperry: Unified consciousness & Behavioural differences in split brain patients,
- Roger Sperry, Gazzaniga's Interpreter theory, Impact on Psychology and Neuroscience, Nobel Prize
- Roger Sperry's Chemoaffinity hypothesis paper
- Roger Sperry paper "Mentalism: Yes, Dualism:No"
- Jens Christian Skou Part 1 :The Story of Jens Christian Skou's life in science
- Jens Christian Skou: Sodium Potassium pump overview & Nobel Prize
- Jens Christian Skou: Paper- "The Influence of Some Cations on an Adenosine Triphosphate
- Arvid Carlsson - Personal Background, Education & Early Career, Pivot, Nobel prize contributions
- Arvid Carlsson: History of L Dopa
- Arvid Carlsson - Antipsychotics, Dopamine hypothesis, Serotonin and SSRIs, Omeprazole
- Eric Kandel - Early life and nobel prize winning work
- Eric Kandel - Synaptic Plasticity
- Eric Kandel - Aplysia work, Short and long term memory & mechanisms
- Paul Greengard - The Phosphorylation Paradigm
- David Hubel & Torsten Wiesel - early life, education and collaboration
- Hubel & Wiesel - Effect of early visual deprivation on cortical function
- Hubel & Wiesel: Effect of visual misalignment on binocular integration
- Hubel & Wiesel: Limited capacity for recovery following early visual deprivation