Course10210600142 lectures
Epigenetics
Prof. Arumugam Rajavelu · IIT Madras
About
Epigenetics is new branch of biology discipline which deals about the study of changes of gene activity without altering the underlying DNA sequence and can be strongly influenced by environmental factors. The eukaryotes are subjected to cell and tissues specific differential gene expression, despite every cells contains the same genetic information. The critical regulators which control these processes are epigenetic players. The fine-tuning of gene expression in every cells are essential for successful development of cells/organisms. Mis-regulation of epigenetics players leads to many chronic diseases. Therefore, it is essential to understand the fundamental process of genes regulation. This course will provide the platform to learn the basics of Molecular Epigenetics, a new layer of gene regulation in eukaryotes and epigenome projects.
Intended audience: Final year B.Tech / M.Sc / M.Tech / MS / PhD Life Sciences
Prerequisites: Molecular Biology
Lectures
Week 1
Week 2
- Introduction to Epigenetic players
- DNA methylation
- De novo DNA methylation
- Functions and regulation of DNMTs
Week 3
- Erasure of DNA methylation
- Epitranscriptome
- Regulators of Epitrasncriptome
- Epigenetic methods Part I
Week 4
- Epigenetic methods Part II and Epigenome Editing
- Introduction to chromatin epigenetics
- Nucleosome assembly & histone inheritance
- Chromatin remodelling
- comprehensive check Week 3&4
Week 5
- Histone code: Acetylation
- Chromatin Epigenetics Methods
- Histone code: HAT & HDAC
- Basics of Histone lysine methylation
Week 6
- Histone code: H3K4 methylation
- Histone code: H3K9 methylation
- Histone code: H3K27 methylation
- Histone code: H3K36 and H4K20
- Comprehensive check Week 5 & 6
Week 7
- Histone core modifications and its fucntions
- Epigenetic Readers - Part 1
- Epigenetic Readers - Part 2
Week 8
Week 9
Week 10
Week 11
Week 12
Syllabus and materials
At NPTEL, as the course publishes them.
Credits and licence
- Institution
- IIT Madras
- Department
- Biotechnology
- Teacher
- Prof. Arumugam Rajavelu
- Level
- Undergraduate
- Language
- English
- Subjects
- Biology
- Source
- NPTEL
- Licence
- CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
- Attribution
- NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
- Who can watch
- NPTEL gives no rating. Invisible Network shows it to Teens profiles and older, judged from what the source says about it. How courses are placed