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Introduction to Cell Biology

Prof. Nagaraj Balasubramanian and Prof. Girish Ratnaparkhi · IISER Pune

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About

This course aims to introduce students to biomolecules and important fundamental concepts in cellular biochemistry, genetics and cellular organisation. It is aimed to give you an insight into how biomolecules work and help drive cellular architecture and function in a eukaryotic cell. In the first part, we focus on the information that makes the cell tick; from its storage in DNA to its conversion to executive molecules such as RNA and protein that perform essential routine processes in the cell. The central dogma is used as a guide to explore the structure of DNA, RNA and Protein and also explore the mechanisms of DNA replication, transcription and translation. Also touched upon are other important molecules such as water, carbohydrates and lipids. In the second part, we introduce basic mechanisms of heredity, as discovered by Gregor Mendel, in a modern context. In the third part, we will be discussing cell theory and the evolution of complexity in cells and the role compartmentalisation plays in mediating the same. The organisation of cells starting from the cell membrane as we move into the cell will be discussed. We will be looking at the role cytoskeleton have in cellular organisation and function. We will also be discussing organisation, role and regulation of cell organelles, everything from the endomembrane system to lysosomes to the nucleus. Eventually, we will be briefly discussing how all these cellular components come together to drive the process of cell division.

Intended audience: First year undergraduate Biology students

Prerequisites: Any student who is starting a BSc course in Biology would find this useful.

Lectures

Week 1

  1. An Overview of Central Dogma of Molecular Biology - Part 1 YouTube
  2. An Overview of Central Dogma of Molecular Biology - Part 2 YouTube
  3. Central Dogma : The DNA Structure - Part 1 YouTube
  4. Central Dogma : The DNA Structure - Part 2 YouTube
  5. Central Dogma : The DNA Structure - Part 3 YouTube
  6. Central Dogma : Replication of DNA - Part 1 YouTube
  7. Central Dogma : Replication of DNA - Part 2 YouTube

Week 2

  1. Central Dogma: Transcription - Part 1 YouTube
  2. Central Dogma: Transcription - Part 2 YouTube
  3. Central Dogma: Transcription - Part 3 YouTube
  4. Central Dogma: Tranlation- Part 1 YouTube
  5. Central Dogma: Tranlation- Part 2 YouTube
  6. Central Dogma: Tranlation- Part 3 YouTube
  7. Protein Structure, Folding and Function - Part 1 YouTube
  8. Protein Structure, Folding and Function - Part 2 YouTube
  9. Secondary Strcuture of Proteins: Ramachandran Plot - Part 1 YouTube
  10. Secondary Strcuture of Proteins: Ramachandran Plot - Part 2 YouTube
  11. Protein Structure, Folding and Function - Part 3 YouTube
  12. Protein Structure, Folding and Function - Part 4 YouTube
  13. Protein Structure, Folding and Function - Part 5 YouTube

Week 3

  1. Protein Structure, Folding and Function - Part 6 YouTube
  2. Enzymes, Carbohydrates and Lipids YouTube
  3. Introduction to Genetics - Part 1 YouTube
  4. Introduction to Genetics - Part 2 YouTube
  5. Introduction to Genetics - Part 3 YouTube
  6. Mendilian and Non-Mendilian Genetics - Part 1 YouTube
  7. Mendilian and Non-Mendilian Genetics - Part 2 YouTube
  8. Mendilian and Non-Mendilian Genetics - Part 3 YouTube

Week 4

  1. Introduction to Microscopy - Part 1 YouTube
  2. Introduction to Microscopy - Part 2 YouTube
  3. Introduction to Microscopy - Part 3 YouTube
  4. Biology of Cells - Part 1 YouTube
  5. Biology of Cells - Part 2 YouTube
  6. Complexity and Compartmentalization in Cells - Part 1 YouTube
  7. Complexity and Compartmentalization in Cells - Part 2 YouTube
  8. Endosymbiont Theory YouTube

Week 5

  1. Structure of the Cell: Cell Wall and Cell Membrane YouTube
  2. Structure of the Cell: Discussion Session YouTube
  3. Plasma Membrane: The Boundaries of Life YouTube
  4. Plasma Membrane: Discussion Session YouTube
  5. Introduction to Cytoskeleton - Part 1 YouTube
  6. Cytoskeleton: Discussion Session 1 YouTube

Week 6

  1. Introduction to Cytoskeleton - Part 2 YouTube
  2. Cytoskeleton: Discussion Session 2 YouTube
  3. Motor Proteins in Cell YouTube
  4. Motor Proteins in Cell: Discussion Session YouTube
  5. Discussion on Directionality of Motor Protein YouTube

Week 7

  1. Endomembrane System of Cells - Part 1 YouTube
  2. Endomembrane System of Cells: Discussion Session 1 YouTube
  3. Endomembrane System of Cells - Part 2 YouTube
  4. Endomembrane System of Cells: Discussion Session 2 YouTube
  5. Endomembrane System of Cells - Part 3 YouTube
  6. Endomembrane System of Cells: Discussion Session 3 YouTube

Week 8

  1. Endomembrane System of Cells - Part 4 YouTube
  2. Endomembrane System of Cells: Discussion Session 4 YouTube
  3. Cell Division YouTube
  4. Cell Division: Discussion session YouTube
  5. Discussion Session on Organization and Function of a Cell YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IISER Pune
Department
Biotechnology
Taught by
Prof. Nagaraj Balasubramanian, Prof. Girish Ratnaparkhi
Level
Undergraduate
Language
English
Subjects
Biology
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge. Coordinated by IIT Madras.
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