Course10810812471 lectures
Electronic Systems for Cancer Diagnosis
Prof. Hardik Jeetendra Pandya · IISc Bangalore
About
This course is designed with an aim of educating students on the process flow for designing electronic systems for tissue-based cancer diagnosis. An exposure towards developing strategies to discriminate pathological cells from normal ones based on the electrophysiological properties of cells. Design and integrate biochip with electronic module for understanding the electro-thermo-mechanical properties of tissues. microtechnology and its use to fabricate sensors and systems. Students will have an exposure towards how to fabricate the sensors and its application in real world. Several examples of engineering devices used in clinical research will be also covered. Both conventional (class 1000) and non-conventional (class 10000) clean room and some equipment within it will also be shown. Below are some of the course outcomes.The first objective of this course is to understand cancer and its properties: Breast Cancer and Oral CancerThe second objective is to educate the students on the process flow for designing electronic systems for tissue-based cancer diagnosisThe third objective is to develop skills to design electronic systems for cytology-based studiesFourth objective is to develop skills to integrate biochips with electronic system for cancer diagnosisThe fifth objective is to understand how to work in a conventional (class 1000) and non-conventional (class 10000) clean room environment and understand several equipmentsThe final objective is to learn and understand in detail how to design electronic systems with the preexisting knowledge of basic electronics and to add on the 3D printing skills.
INTENDED AUDIENCE : Engineering Students, Faculty from Engineering Colleges
PREREQUISITES : Basic Electronics/Microfabrication
Lectures
Week 1 Tissue and Cell Culture Techniques
- Tissue and Cell Culture Techniques: Introduction
- Tissue and Cell Culture Techniques: Methods
- Tissue and Cell Culture Techniques: Devices
- Cleanroom Equipments
- Cleanroom Equipments Contd…
Week 2 Photolithography and micromachining techniques
- Introduction to photolithography
- Photolithography: Mask Aligner
- Photolithography: Designing Mask Aligner
- Micromachining Techniques
Week 3 Tissue Related Cancers- Breast Cancer and Oral Cancer
- Breast Cancer and Oral Cancer Statistics
- Fabrication of MEMs-based Biochip for cancer diagnosis
- Fabrication of MEMs-based Biochip for cancer diagnosis Contd..
- Fabrication of Piezoresistive Sensor
- Fabrication of Piezoresistive Sensor Contd..
- Fabrication of SU-8 pillar on piezoresistive Sensor
Week 4 Bio-MEMS for Breast Cancer Diagnosis
- Portable Cancer Diagnostic Tool Using a Disposable MEMS-Based Biochip
- Mechanical Phenotyping of Breast Cancer using MEMS
- Electrical characterization of Breast Tissue Cores
- Fabrication of MEMS-based sensor for electro-mechanical phenotyping of breast cancer
- Fabrication of electro-mechanical sensor contd..
- Assemby of the electro-mechanical sensor
- Silicon substrate devices for breast cancer diagnosis
Week 5 Cell & Tissue Morphology
- Understanding the methods and mechanism to study cell morphology
- Cytology - A detail study on Spin Coater and Cytospin
- Techniques in oral cytology studies
- Techniques in cell morphology analysis
- Comparitive study on diagnostic tools for oral cancer screening
Week 6 Amplifiers and Filters
- Basic building blocks of Electronics System: Amplifiers
- Basic building blocks of Electronics System: Amplifiers (contd..)
- Basic building blocks of Electronics System: Amplifiers (contd..)
- Basic building blocks of Electronics System: Filters
- Basic building blocks of Electronics System: Filters (contd..)
- Basic building blocks of Electronics System: Filters (contd..)
Week 7 Filters and Data Converters
- Basic building blocks of Electronics System: Data Converteres
- Basic building blocks of Electronics System: Data Converteres (contd.. )
- Basic building blocks of Electronics System: Signal Conditioning Circuits
- Etching Process and Figure of Merits
Week 8 Practical Applications: ECG Signal Processing
- ECG Signal Processing to calculate BPM
- ECG Signal Processing to calculate BPM (contd...)
- ECG Signal Processing to calculate BPM (contd...)
- ECG Signal Processing to calculate BPM (contd...)
Week 9 Bio-MEMS Applications
- ECG Signal Processing to calculate BPM (contd...)
- ECG Signal Processing to calculate BPM (contd...)
- MEMS based Force Sensor for Catheter Contact Force Measurement
- 3D Printing: Introduction and Work Flow
- 3D Fabrication Techniques
Week 10 Lab: Introduction to Clean Room and Cleanroom Equipments
- Gowning Procedure in Clean Room
- Introduction to Equipments: Desiccators
- PDMS Moulding procedure
- Introduction to Equipments: Pristaltic Pump
- Introduction to Equipments: Stereo Microscopy, Metallurgical Microscopy, Inverted Microscopy
- Micromanipulator
Week 11 Demonstration of Cleanroom Equipments
- Biosafety Cabinet & Ultrasonicbath
- Incubator Shaker
- Hotplate and Microcentrifuge
- Autoclave
- Impedance Analyser
- Rapid Prototyping using 3D Printer
- Etching Process
- Electronic System for Drug Screening
Week 12 Data Acquisition and simulation of MEMS sensors
- Introduction to Equipments: DAQ
- Introduction to Equipments: DAQ contd…
- Electronic Module for Gas sensor
- Fabrication process flow for a metal oxide gas sensor
- MEMS Simulation using Comsol Multiphysics
- Introduction to COMSOL Multiphysics
- COMSOL Examples for MEMS Applications
- COMSOL Examples for MEMS Applications (cotd…)
- Deomonstaration oof Thermal Acutator and Understanding of Application Builder
- Closed loop control of temperature sensor
- Experimental Set-up of closed loop control of temperature sensor
Syllabus and materials
At NPTEL, as the course publishes them.
Credits and licence
- Institution
- IISc Bangalore
- Department
- Electrical Engineering
- Teacher
- Prof. Hardik Jeetendra Pandya
- Level
- Undergraduate
- Language
- English
- Subjects
- Engineering
- Source
- NPTEL
- Licence
- CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
- Attribution
- NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
- Who can watch
- NPTEL gives no rating. Invisible Network shows it to Teens profiles and older, judged from what the source says about it. How courses are placed