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Course10410807841 lectures

Principles and Applications of NMR Spectroscopy

Prof. H. S. Atreya · IISc Bangalore

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Lectures

Introduction to NMR spectroscopy

  1. Lec1- Introduction to NMR spectroscopy Video
  2. Lec2-The alignment of nuclear spins in presence of magnetic field Video
  3. Lec3-Introduction to rotating frame Video
  4. Lec4-Free induction decay and Fourier transformation of FID Video
  5. Lec5-NMR Hardware Video

Chemical shifts and J-coupling

  1. Lec6-The concept of chemical shift Video
  2. Lec7-Factors that affect chemical shifts Video
  3. Lec8-Chemical shift referencing Video
  4. Lec9-J- coupling Video
  5. Lec10-Recap of basics Video

One-dimensional proton NMR

  1. Introduction to general one dimensional NMR experiment Video
  2. Practical aspects of recording a 1D NMR experiment I Video
  3. Practical aspects of recording a 1D NMR experiment II Video
  4. Practical aspects of recording a 1D NMR experiment III Video
  5. NMR Data processing Video

One dimensional NMR of X-nuclei (13C, 15N, 31P and 19F)

  1. Lec16-Basic aspects of 1D proton NMR analysis Video
  2. Lec17-Analysis of an example 1D proton spectrum Video
  3. Lec18-Analysis of 1D 1H NMR spectra of molecules I Video
  4. Lec19-Analysis of 1D 1H NMR spectra of molecules II Video
  5. Lec20-1D 13C NMR Video

Homonuclear 2D NMR

  1. Lec21-Why do we need 2D NMR Video
  2. Lec22-A qualitative explanation of how 2D NMR experiment works Video
  3. Lec23-Principles of 2D COSY and Total correlation spectroscopy (2D TOCSY) Video
  4. Lec24-2D NOE-spectroscopy Video
  5. Lec25-2D NOESY and 2D ROESY Video

Heteronuclear 2D NMR

  1. Lec26-What is heteronuclear correlation NMR spectroscopy Video
  2. Lec27-Sensitivity enhancement of heternuclei via polarization transfer Video
  3. Lec28-Heteronucler multiple quantum NMR spectroscopy (2D HMQC) and Heteronuclear single quantum NMR spectroscopy (2D HSQC) Video
  4. Lec29-Practical aspects of recording and processing 2D HMQC or HSQC Video
  5. Lec30-HMBC and its utility Video

Structure determination of molecules

  1. Lec31-2D HSQC TOCSY and its analysis with examples Video
  2. Lec32-Structure determination of molecules by NMR Video
  3. Lec33-Structure determination of peptides I Video
  4. Lec34-Structure determination of peptides II Video
  5. Lec35-Structure determination of peptides III Video

Advanced topics (Solvent suppression, Drug Discovery, DOSY)

  1. Lec36-Chemical exchange Video
  2. Lec37-Hydrogen or deuterium exchange Video
  3. Lec38-Diffusion ordered spectroscopy DOSY I Video
  4. Lec39-DOSY II Video
  5. Lec40-STD NMR for drug target interactions Video

Live Session

  1. Live Session 05-03-2020 Video

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IISc Bangalore
Department
Chemistry and Biochemistry
Teacher
Prof. H. S. Atreya
Level
Undergraduate
Language
English
Subjects
Chemistry
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
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