Course10410812465 lectures
One and Two Dimensional NMR Spectroscopy for Chemists
Prof. N. Suryaprakash · IISc Bangalore
About
In this course, I will discuss fundamental concepts of NMR spectroscopy, experimental determination of NMR spectral parameters, their interpretation, selective and broadband homo and Heteronuclear spin decoupling, numerous examples of the analysis of NMR spectra of 1H, 13C and other heteronuclei will be given. The relaxation processes, their measurement and utility in understanding molecular dynamics, the polarization transfer mechanism, the spectral editing techniques, such as, APT, DEPT, INEPT will also be discussed. Two dimensional NMR and the commonly employed experiments, viz., COSY, TOCSY, HSQC, HMQC, HMBC, NOESY, etc will be discussed with number of examples. The practical aspects of one and two dimensional NMR data acquisition and processing will also be highlighted. The solid state NMR, magic angle spinning and cross polarization will also be discussed.
Intended audience: It is for chemistry students, pharmaceutical students, biology students
Lectures
WEEK 1 Concepts of NMR spin physics - 1
- NMR an historical perspective and NMR active nuclei
- Spin Angular Momentum and Magnetic moment
- Interaction of Spins with the magnetic field
- Larmor Precession and Energy of interaction
- NMR detection and sensitivity
WEEK 2 Concepts of NMR spin physics - 2
- Inducing Resonance and Bulk Magnetization
- Signal detection and Rotating Frame Concept
- Pulse phase and signal phase
- FID and Fourier Transformation
- Selection rules and transitions
WEEK 3 NMR Internal interaction parameters
- External and Internal interactions in NMR
- Chemical Shifts
- NMR Spectrum and chemical equivalence
- Conversion of frequency and ppm
- Field dependence and factors affecting chemical shift
WEEK 4 Chemical Shifts and Couplings
- Factors contributing to chemical shifts
- Factors contributing to chemical shifts -2
- Scalar Couplings
- Scalar Couplings -2
- Energy levels of coupled spins
WEEK 5 Coupled spin systems and multiplicity patterns
- Spin system classification and multiplicity
- Multiplicity pattern of coupled spins
- Active and passive coupling
- Coupling among equivalent spins
- Coupling among equivalent spins – 2
WEEK 6 Multiplicity patterns and nomenclature of coupled spins
- Coupling among non-equivalent spins
- Geminal and Vicinal couplings
- Spin system Nomenclature
- Isotope effect
- Analysis of Strongly coupled spin systems
WEEK 7 Multiplicity patterns and nomenclature of coupled spins - 2
- Eigen values of A2 and AMX spin systems
- Analysis of Three spin coupled systems
- Analysis of Proton NMR spectra
- Analysis of Proton NMR spectra – 2
- Analysis of Proton NMR spectra – 3
WEEK 8 13C-NMR spectra
- Basics of 13C-NMR
- Coupled and Decoupled 13C-Spectra
- Broadband decoupling in 13C-NMR
- Analysis of 13C spectra and DEPT
- Heteronuclear couplings and satellite analysis
WEEK 9 Heteronuclear spectra
- Heteronuclear couplings and satellite analysis -2
- Coupling among magnetic equivalent nuclei and isotope effect
- Analysis of spectra of other nuclei
- Spin Echoes
- Polarization transfer techniques
WEEK 10 NOE and Two-dimensional NMR
WEEK 11 Two dimensional Techniques
- Two dimensional NMR
- Two dimensional COSY
- COSY and examples
- Variants of COSY and TOCSY spectra
- Heteronuclear correlation and inverse detection
WEEK 12 Part 1 1D Data acquisition and processing
Syllabus and materials
At NPTEL, as the course publishes them.
Credits and licence
- Institution
- IISc Bangalore
- Department
- Chemistry and Biochemistry
- Teacher
- Prof. N. Suryaprakash
- Level
- Graduate
- Language
- English
- Subjects
- Chemistry
- Source
- NPTEL
- Licence
- CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
- Attribution
- NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
- Who can watch
- NPTEL gives no rating. Invisible Network shows it to Tweens profiles and older, judged from what the source says about it. How courses are placed