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Course10410512063 lectures

Organic Chemistry in Biology and Drug Development

Prof. Amit Basak · IIT Kharagpur

Start with lecture 1 At NPTEL

About

In the biosphere, the chemistry must be considered in the context of the cell, or an organ, or even a whole organism. That makes mimicking of biological processes to be extremely challenging as the reaction needs to be performed with perfect orthogonality to other functional entities present in a biological system. Today, with the advancement of various spectroscopic and molecular biology techniques and with a better understanding of chemical principles, functions of various bio molecules have been unravelled which has paved the way for development of newer drugs. The present course is an attempt to bridge the gap in our understanding of biological systems and processes at the molecular and functional level. The course first introduces the various kinds of bio molecules, macro to medium size to small, their structures and functions followed by molecular engineering to manipulate their activity and biosynthesis. That creates a perfect platform for the next module on drug design and discovery

INTENDED AUDIENCE : Chemistry, Biochemistry, Chemical Biology, Pharmacy Students/faculty

PREREQUISITES : Basic Organic Chemistry

Lectures

Week 1 :

  1. Lecture 01: A brief introduction to Molecules of Life: Structure of Amino acids and their various charged forms YouTube
  2. Lecture 02: Biological Macromolecules and Small molecules: Importance and functions YouTube
  3. Lecture 03: Amino Acids: The building block of proteins YouTube
  4. Lecture 04: Amino acids: separation and detection, Electrophoresis and Ninhydrin reaction YouTube

Week 2 :

  1. Lecture 05 : Method of determination of Amino acid sequence: primary structure of polypeptide/protein YouTube
  2. Lecture 06 : Selective peptide bond cleavage: Enzymatic and Non-enzymatic methods YouTube
  3. Lecture 07 : Peptide synthesis: Protecting groups for amine and carboxyl functionality YouTube
  4. Lecture 08 : Peptide synthesis (continued): Protection, coupling and deprotection methods YouTube
  5. Lecture 09 : Recent development of coupling agents; Merrifield’s method of solid phase peptide synthesis YouTube

Week 3 :

  1. Lecture 10 : Hierarchial structure of proteins: Secondary, tertiary and quaternary structure YouTube
  2. Lecture 11 : Ramachandran plot and protein purification techniques YouTube
  3. Lecture 12 : Protein purification techniques (continued).. YouTube
  4. Lecture 13 : Introduction to Enzymes and its kinetics YouTube
  5. Lecture 14 : Enzyme catalysed reactions and introduction to catalytic activity of proteases YouTube

Week 4 :

  1. Lecture 15 : Enzyme Kinetics (Contd.) YouTube
  2. Lecture 16 : Concept of Enzyme Inhibition YouTube
  3. Lecture 17 : Concept of Enzyme Inhibition (Contd.) YouTube
  4. Lecture 18 : Problems on Enzyme Kinetics and Enzyme Inhibition YouTube
  5. Lecture 19 : Synthetic Biology YouTube
  6. Lecture 20 : Synthetic Biology (Contd.) YouTube

Week 5 :

  1. Lecture 21 : Synthetic Biology (Contd.) YouTube
  2. Lecture 22 : Nucleic Acid YouTube
  3. Lecture 23 : Nucleic Acid (Contd.) YouTube
  4. Lecture 24 : DNA sequencing method YouTube
  5. Lecture 25 : DNA sequencing method (Contd.) YouTube
  6. Lecture 26 : DNA sequencing method (Contd.) YouTube

Week 6 :

  1. Lecture 27 : Synthesis of oligonucleotide YouTube
  2. Lecture 28 : Central dogma: DNA replication, transcription and translation YouTube
  3. Lecture 29 : Central dogma: DNA replication, transcription and translation (Contd.) YouTube
  4. Lecture 30 : Central dogma: DNA replication, transcription and translation (Contd.) YouTube
  5. Lecture 31 : Central dogma: DNA replication, transcription and translation (Contd.) YouTube
  6. Lecture 32 : Central dogma: DNA replication, transcription and translation (Contd.) YouTube

Week 7 :

  1. Lecture 33 : Molecular Biology YouTube
  2. Lecture 34 : Molecular Biology (Contd.) YouTube
  3. Lecture 35 : Chemistry of cofactors/coenzymes YouTube
  4. Lecture 36 : Chemistry of cofactors/coenzymes (Contd.) YouTube

Week 8 :

  1. Lecture 37 : Chemistry of cofactors/coenzymes (Contd.) YouTube
  2. Lecture 38 : Chemistry of cofactors/coenzymes (Contd.) YouTube
  3. Lecture 39 : Chemistry of cofactors/coenzymes (Contd.) YouTube
  4. Lecture 40 : Chemistry of cofactors/coenzymes (Contd.) YouTube

Week 9 :

  1. Lecture-41: Introduction to Drug Discovery Process YouTube
  2. Lecture-42: Fundamental Principles of Drug Development Process YouTube
  3. Lecture-43: Combinatorial chemistry YouTube
  4. Lecture-44: Neurotransmitters YouTube
  5. Lecture-45: Catechol amine based and GABA neurotransmitters YouTube
  6. Lecture-46: Hypertension: humoral mechanism and renin/angiotensin system YouTube
  7. Lecture-47: Inhibitor design of angiotensin converting enzyme YouTube

Week 10 :

  1. Lecture 48: Antimicrobial drugs YouTube
  2. Lecture 49: Chemistry of penicillins YouTube
  3. Lecture 50:Resistance to beta-lactam antibiotics YouTube
  4. Lecture 51: Mechanistic studies of beta-lactamase YouTube
  5. Lecture 52: Non beta-lactam antibiotics YouTube
  6. Lecture 53: Mechanistic enzymology of Isopenicillin N synthase YouTube

Week 11 :

  1. Lecture 54 : Polyketide Biosynthesis YouTube
  2. Lecture 55 : Biosynthesis of macrolide polyketides and introduction to virus YouTube
  3. Lecture 56 : Anti-viral drugs YouTube

Week 12 :

  1. Lecture 57 : Cancer and Chemotherapy YouTube
  2. Lecture 58 : Ant-cancer drugs (contd) YouTube
  3. Lecture 59 : Aromatase inhibition and Anti-ulcer drugs YouTube
  4. Lecture 60 : Cholesterol lowering agents YouTube
  5. Lecture 61 : Cholesterol Biosynthesis YouTube
  6. Lecture 62 : Pharmakinetics and pharmadynamics YouTube
  7. Lecture 63 : QSAR principles YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Kharagpur
Department
Chemistry and Biochemistry
Teacher
Prof. Amit Basak
Level
Graduate
Language
English
Subjects
Chemistry
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
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