Podcasts · The Human Upgrade: Biohacking for Longevity & Performance

I Tried EVERY Legal Focus Drug, Here’s What Actually Works : 1496

5 Jul 2026 · 17 min · Episode 1496

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Try Danger Coffee: https://dangercoffee.com/

Try Suppgrade Labs: https://shopsuppgradelabs.com/

I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash.

The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state.

Thank you to our sponsors!

• ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. • EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. • iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Timestamps:

0:00 – The Longevity Switch

0:47 – Why Mitochondria Matter

2:28 – What Mitophagy Is

2:46 – How Mitophagy Works

4:18 – What Shuts It Off

8:54 – The Damage Compounds

9:22 – How to Turn It Back On

10:31 – Signal 1: Fasting

11:48 – Signal 2: Exercise (REHIT)

12:30 – Signal 3: Cold Exposure

13:22 – Signal 4: NAD+

14:29 – Signal 5: Urolithin A and Spermidine

Connect with Dave Asprey!

Website: https://daveasprey.com

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Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey’s BEYOND Conference: https://beyondconference.com/

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

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Links in the notes 3

• https://www.emr-tek.com/DAVE
• https://art19.com/privacy
• https://art19.com/privacy#do-not-sell-my-info