Podcasts · This Week in Virology
TWiV 1275: An amazing sequence and a gutsy therapy
· 1 h 49 min · Episode 1275
Episode TWiV 1275: An amazing sequence and a gutsy therapy
TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
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Links for this episode
• Support science education at MicrobeTV • Immune 100 live at the Incubator • Spliced segments of adenovirus mRNA (PNAS) • An amazing sequence in adenovirus mRNA (Cell) • Nobel Prize for mRNA splicing (Nobel) • A predominant undecanucleotide in adenovirus late mRNAs (Cell) • Splicing RNA with Phillip A. Sharp (ASM) • Protein production in the gut by engineered phage (Nat Biotech) • Engineered phage T4 (Curr Op Virol) • Timestamps by Jolene Ramsey. Thanks!
Weekly Picks
Brianne – Can You Identify These Lines from Classic SciFi Novels? Kathy – Saturday Morning Physics, Photograph 51 and JCE article Rich – Wikipedia:Wiki Science Competition 2025 in the United States Jolene – Data visualization workshop Vincent – Transformer: The Deep Chemistry of Life and Death by Nick Lane
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
Links in the notes 20
- https://en.wikipedia.org/wiki/Vincent_Racaniello
- https://medschool.umich.edu/profile/879/katherine-spindler
- https://bbarkerdrew.com/
- https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065
- https://www.microbe.tv/contribute
- https://www.eventbrite.com/e/immune-100-live-in-nyc-tickets-1797664816859?aff=oddtdtcreator
- https://pmc.ncbi.nlm.nih.gov/articles/PMC431482/
- https://pubmed.ncbi.nlm.nih.gov/902310/
- https://www.nobelprize.org/prizes/medicine/1993/press-release/
- https://pubmed.ncbi.nlm.nih.gov/884734/
- https://www.microbe.tv/twiv/twiv-462/
- https://www.nature.com/articles/s41587-025-02570-7
- https://doi.org/10.1016/j.coviro.2022.101255
- https://ramseylab.vercel.app/
- https://www.nytimes.com/interactive/2025/11/24/books/review/classic-sf-quotes.html
- https://www.youtube.com/watch?v=yvY61ArnxPg&list=PLkCzlk8e8aNfPZoSgvp6m-aRmY4lsUbD6&index=3&pp=iAQB
- https://www.youtube.com/watch?v=48A-tlOvml0&t=2354s
- https://pubs.acs.org/doi/10.1021/ed076p378
- https://en.wikipedia.org/wiki/Wikipedia:Wiki_Science_Competition_2025_in_the_United_States
- https://bookdown.org/taiawu/data_viz_course/
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