Learn · Introduction to Evolutionary Dynamics
Lecture 60 of 62week-12
Week 12 : Lecture 60 : Synonymous mutations have fitness effects. Mutation Accumulation Experiments.
Prof. Supreet Saini · IIT Bombay
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- From
- Introduction to Evolutionary Dynamics, IIT Bombay (at NPTEL)
- Licence
- CC BY-NC-SA, as NPTEL states it. Non-commercial use only.
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All the lectures
- Week 1: Lecture 1 : Story of proposal of the theory of natural selection.
- Week 1 : Lecture 2 : Natural Selection; Patrick Matthew. History of life on earth
- Week 1 : Lecture 3 : Where did life come from?
- Week 1 : Lecture 4 : Elements of theory of natural selection.
- Week 1 : Lecture 5 : Limitations of Darwins proposal of theory of natural selection.
- Week 2 : Lecture 6 : Natural selection in action in ecology.
- Week 2 : Lecture 7 : Central Dogma of Molecular Biology.
- Week 2 : Lecture 8 : Gene expression in biology
- Week 2 : Lecture 9 : Numbers in E. coli
- Week 2 : Lecture 10 : Growth and evolution in microbial populations.
- Week 3 : Lecture 11 : Mutations and errors in DNA replication.
- Week 3 : Lecture 12 : How does E. coli divide?
- Week 3 : Lecture 13 : How does evolution take place in sexually reproducing organisms?
- Week 3 : Lecture 14 : Growth in batch culture.
- Week 3 : Lecture 15 : How to define fitness in a batch culture?
- Week 4 : Lecture 16 : Model for growth in exponential growth.
- Week 4 : Lecture 17 : Logistic model for growth.
- Week 4 : Lecture 18 : Growth in a chemostat.
- Week 4 : Lecture 19 : Modeling genotype competition in a chemostat.
- Week 4 : Lecture 20 : Mutations and their selection coefficients.
- Week 5 : Lecture 21 : Distribution of fitness effects (DFE)
- Week 5 : Lecture 22 : Sequence Space and Fitness Landscape.
- Week 5 : Lecture 23 : Epistasis and structure of landscape.
- Week 5 : Lecture 24 : Epistasis and structure of landscape.
- Week 5 : Lecture 25 : Landscape of antibiotic resistance.
- Week 6 : Lecture 32 : IPsec and Virtual Private Networks (VPNs) for Network-Layer Security: Part 1
- Week 6 : Lecture 33 : IPsec and Virtual Private Networks (VPNs) for Network-Layer Security: Part 2
- Week 6 : Lecture 34 : IPsec and Virtual Private Networks (VPNs) for Network-Layer Security: Part 3
- Week 6 : Lecture 35 : Securing Wireless LANs : Part 1
- Week 6 : Lecture 36 : Securing Wireless LANs : Part 2
- Week 7 : Lecture 31 : Marbles in a jar continued.
- Week 7 : Lecture 32 : Moran Process
- Week 7 : Lecture 33 : Transition probability in Moran process.
- Week 7 : Lecture 34 : Fixation probability.
- Week 7 : Lecture 35 : Fixation probability of a neutral mutation.
- Week 8 : Lecture 36 : Fixation probability of a beneficial mutation.
- Week 8 : Lecture 37 : Fixation probability of a beneficial mutation - contd.
- Week 8 : Lecture 38 : Fixation probability of a beneficial mutation - contd.
- Week 8 : Lecture 39 : Time of occurance of mutations.
- Week 8 : Lecture 40 : Graphical representation of evolving populations.
- Week 9 : Lecture 41 : Time of fixation of mutations.
- Week 9 : Lecture 42 : Estimating t_wait.
- Week 9 : Lecture 43 : Traveling wave model of microbial evolution.
- Week 9 : Lecture 44 : Deriving traveling wave model equations.
- Week 9 : Lecture 45 : dN/dS
- Week 10 : Lecture 46 : dN/dS contd., and how to do an evolution experiment in lab?
- Week 10 : Lecture 47 : Serial Subculture Experiment.
- Week 10 : Lecture 48 : Evolution in Chemostat & Mutation Accumulation Experiment.
- Week 10 : Lecture 49 : Megaplate Experiment.
- Week 10 : Lecture 50 : Long Term Evolution Experiment (LTEE)
- Week 11 : Lecture 51 : Fitness trajectory with number of generations.
- Week 11 : Lecture 52 : Second order selection - mutation rate.
- Week 11 : Lecture 53 : Do fitness landscapes have a peak?
- Week 11 : Lecture 54 : Do fitness landscapes have a peak?.. Contd.
- Week 11 : Lecture 55 : Metabolic innovation in a lab evolution experiment?
- Week 12 : Lecture 56 : Selection vs. Drift
- Week 12 : Lecture 57 : Historical Contingency in evolution.
- Week 12 : Lecture 58 : Unicellularity to Multicellularity.
- Week 12 : Lecture 59 : Adaptive diversification in microbial populations.
- Week 12 : Lecture 60 : Synonymous mutations have fitness effects. Mutation Accumulation Experiments.
- Live Session 10-02-2025
- Live Session 03-03-2025