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Course10410513960 lectures

Overview and Integration of Cellular Metabolism

Prof. Aritri Bir and Prof. Arindam Ghosh · IIT Kharagpur

Start with lecture 1 At NPTEL

About

Every single cell in human body is constantly engaged in millions of chemical reactions that are vital to the survival of the cell and, by extension, the entire human body. The term "metabolism" is used to describe the sum total of a cell's chemical reactions. It encompasses intake, utilization, transport, breakdown and formation of different biomolecules which themselves are interconnected to each other through a complex metabolic web. The course will provide a detailed in-depth knowledge to the major metabolic pathways from a clinical perspective. It will also discuss the important human diseases related to metabolism.

Intended audience: MBBS students, Post Graduate students of MD Biochemistry, Senior Residents of Biochemistry, Young Biochemistry teaching faculties, MSc Medical Biochemistry students, BDS students, BSc Nursing. BSc Biological Science, BSc Nutrition, Students preparing for NEET PG and NEET SS examinations.

Prerequisites: Basic concepts in Chemistry and Biology

Lectures

Week 1

  1. Lecture 01: Bioenergetics: Understanding the significance in Biological Systems YouTube
  2. Lecture 02: Regulation of Enzyme Activity YouTube
  3. Lecture 03: Digestion and Absorption of Carbohydrates YouTube
  4. Lecture 04: Glycolysis, alcohol and lactic acid fermentation YouTube
  5. Lecture 05: Biochemistry of TCA Cycle (I) YouTube

Week 2

  1. Lecture 06: TCA Cycle (II) – Regulation and special characteristics. YouTube
  2. Lecture 07: Neoglucogenesis YouTube
  3. Lecture 08: Regulation of Glycolysis and Neoglucogenesis (I) YouTube
  4. Lecture 09: Regulation of Glycolysis and Neoglucogenesis (II) Cori Cycle, Rapoport Leubering Cycle, Futile Cycle YouTube
  5. Lecture 10: Hexose Monophosphate Shunt : Steps and Phases YouTube

Week 3

  1. Lecture 11: Hexose Monophosphate Shunt : Regulation and Significance YouTube
  2. Lecture 12: Glycogen Metabolism (I) YouTube
  3. Lecture 13: Glycogen Metabolism (II) YouTube
  4. Lecture 14: Glycogen Metabolism (III) YouTube
  5. Lecture 15: Glycogen Metabolism (IV) YouTube

Week 4

  1. Lecture 16: Galactose Metabolism and Associated Disorders YouTube
  2. Lecture 17: Fructose Metabolism and Associated Disorders YouTube
  3. Lecture 18: Regulation of Blood Glucose YouTube
  4. Lecture 19: Diabetes Mellitus and Metabolic Alterations YouTube
  5. Lecture 20: Digestion and absorption of Lipid. YouTube

Week 5

  1. Lecture 21: Lipoprotein Metabolism (I) YouTube
  2. Lecture 22: Lipoprotein Metabolism (II) YouTube
  3. Lecture 23: Lipoprotein metabolism (III) YouTube
  4. Lecture 24: Fatty acid catabolism (Oxidation of Fatty acids) - I YouTube
  5. Lecture 25: Fatty acid catabolism (Oxidation of Fatty acids) - II YouTube

Week 6

  1. Lecture 26: Fatty acid catabolism (Oxidation of Fatty acids) - III YouTube
  2. Lecture 27: Metabolism of Ketone Bodies YouTube
  3. Lecture 28: Biosynthesis of Fatty acid and its regulation YouTube
  4. Lecture 29: Biosynthesis of triacylglycerol, phosphoglycerides and sphingolipids YouTube
  5. Lecture 30: Cholesterol Metabolism YouTube

Week 7

  1. Lecture 31: Digestion and absorption of Protein YouTube
  2. Lecture 32: Transformation of Amino acids YouTube
  3. Lecture 33: Metabolism of Ammonia and ammonia toxicity YouTube
  4. Lecture 34: Urea cycle- Steps, Significance and Energetics YouTube
  5. Lecture 35: Urea Cycle – Regulation and Enzyme Deficiency Disorders YouTube

Week 8

  1. Lecture 36: Metabolism of Phenylalanine and Associated Disorders YouTube
  2. Lecture 37: Tyrosine Metabolism - I YouTube
  3. Lecture 38: Tyrosine Metabolism – II (Catecholamines) YouTube
  4. Lecture 39: Tyrosine Metabolism - III YouTube
  5. Lecture 40: Tryptophan Metabolism YouTube

Week 9

  1. Lecture 41: Metabolism of Sulphur containing Amino acids (Methionine and Cysteine) YouTube
  2. Lecture 42: Metabolism of Glycine and its disorders YouTube
  3. Lecture 43: Metabolism of Serine, Threonine and Alanine YouTube
  4. Lecture 44: Branched chain amino acid metabolism and their disorders YouTube
  5. Lecture 45: Metabolism of Histidine, Proline, Arginine and Lysine YouTube

Week 10

  1. Lecture 46: Heme Metabolism – I (Heme Synthesis and Regulation) YouTube
  2. Lecture 47: Heme Metabolism – II (Disorders of Heme Synthesis - Porphyrias) YouTube
  3. Lecture 48: Heme Metabolism -III (Heme Degradation, Transport and Bilirubin Metabolism) YouTube
  4. Lecture 49: Disorders of Bilirubin Metabolism YouTube
  5. Lecture 50: Nucleotide Metabolism – I (Purine Metabolism) YouTube

Week 11

  1. Lecture 51: Nucleotide Metabolism – II (Disorders of Purine Metabolism) YouTube
  2. Lecture 52: Nucleotide Metabolism – III (Pyrimidine Metabolism and Disorders) YouTube
  3. Lecture 53: Inborn errors of Metabolism YouTube
  4. Lecture 54: Integration of Metabolism I (Cellular and Organ level integration) YouTube
  5. Lecture 55: Integration of Metabolism II (Starve feed cycle) YouTube

Week 12

  1. Lecture 56: Integration of Metabolism III (Metabolic Control Analysis) YouTube
  2. Lecture 57: Obesity, Metabolic Syndrome and Role of Adipokines YouTube
  3. Lecture 58: Fatty Liver and alcohol metabolism YouTube
  4. Lecture 59: Energy metabolism and Nutritional disorders, Protein Energy Malnutrition and Dietary Fibres YouTube
  5. Lecture 60: Metabolism in Cancer Cells YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Kharagpur
Department
Chemistry and Biochemistry
Taught by
Prof. Aritri Bir, Prof. Arindam Ghosh
Level
Undergraduate
Language
English
Subjects
Chemistry
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
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