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Course10410513340 lectures

Principles and applications of enolate alkylation: A unique strategy for construction of C-C (sp3 -sp3) bonds in asymmetric fashion

Prof. Samik Nanda · IIT Kharagpur

Start with lecture 1 At NPTEL

Lectures

week-01

  1. Lecture : 01 - Enolate generation, structure of enolates and related topic - I Video
  2. Lecture : 02 - Enolate generation, structure of enolates and related topic - II Video
  3. Lecture : 03 - Enolate generation, structure of enolates and related topic - III Video
  4. Lecture : 04 - Different mode of asymmetric induction in enolate alkylation Video
  5. Lecture : 05 - Revisit again, Different mode of asymmetric induction in enolate alkylation Video

week-02

  1. Lecture : 06 - Substrate directed stereocontrol in acyclic and cyclic system Video
  2. Lecture : 07 - Substrate directed enolate alkylation in bicyclic system Video
  3. Lecture : 08 - Seebach’s SRS principle and related systems Video
  4. Lecture : 09 - Seebach’s SRS principle and related systems -II Video
  5. Lecture : 10 - Seebach’s SRS principle and related systems - III Video

week-03

  1. Lecture : 11 - Evans oxazolidinone and related systems - I Video
  2. Lecture : 12 - Evans oxazolidinone and related systems - II Video
  3. Lecture : 13 - Evans oxazolidinone and related systems - III Video
  4. Lecture : 14 - Evans oxazolidinone and related systems - IV Video
  5. Lecture : 15 - Evans oxazolidinone and related systems - V Video

week-04

  1. Lecture : 16 - Helmchen’s auxiliary, Oppolzer’s sultam based auxiliary Video
  2. Lecture : 17 - Camphor based N-acyloxazolidinones as chiral auxiliary Video
  3. Lecture : 18 - Myer’s ephedrine, Chiral Weinreb amide equivalents and related systems Video
  4. Lecture : 19 - Myer’s ephedrine and related systems Video
  5. Lecture : 20 - Chiral Weinreb amide equivalents and related systems Video

week-05

  1. Lecture : 21 - Meyer’s oxazoline based alkylation - I Video
  2. Lecture : 22 - Meyer’s oxazoline based alkylation - II Video
  3. Lecture : 23 - Meyer’s bicyclic lactam based enolate alkylation Video
  4. Lecture : 24 - Meyer’s bicyclic lactam based alkylation Video
  5. Lecture : 25 - Meyer’s bicyclic lactams, Gleason’s bicyclic thioglycolate lactam based systems Video
  6. Lecture : 26 - Few problem solving from Meyer’s oxazoline/bicyclic lactam based alkylation Video

week-06

  1. Lecture : 27 - Schollkopf’s bis-lactim ether and related systems; Auxiliary induced chiral relay Video
  2. Lecture : 28 - Chiral relay systems in amino acid derived enolate alkylation Video
  3. Lecture : 29 - Wiliams oxazinone, Yamada's chiral glycine enolate and related system Video
  4. Lecture : 30 - Tricycloiminolactone as chiral glycine equivalents Video
  5. Lecture : 31 - Najera's auxiliary, Davies diketopoperazine and related system Video

week-07

  1. Lecture : 32 - Ender’s RAMP/SAMP,Coltart’s cyclic carbamate hydrazone,Ellman’s sulfinamide & related Video
  2. Lecture : 33 - Ender’s RAMP/SAMP based systems Video
  3. Lecture : 34 - Ender’s RAMP/SAMP based systems Video
  4. Lecture : 35 - Ender’s RAMP/SAMP, Coltart’s cyclic carbamate hydrazone,Ellman’s sulfinamide Video

week-08

  1. Lecture : 36 - Coltart’s cyclic carbamate hydrazone and its exploration Video
  2. Lecture : 37 - Memory of chirality in enolate alkylation Video
  3. Lecture : 38 - Organocatalytic methods for enolate alkylation (SOMO activation) Video
  4. Lecture : 39 - Enantioselective alkylation with chiral PTC Video
  5. Lecture : 40 - Overall analysis of the entire discussion Video

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Kharagpur
Department
Chemistry and Biochemistry
Teacher
Prof. Samik Nanda
Level
Undergraduate
Language
English
Subjects
Chemistry
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
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