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Course10410513060 lectures

Biological Inorganic Chemistry

Prof. Debashis Ray · IIT Kharagpur

Start with lecture 1 At NPTEL

About

The extraordinary important role of metal ions in biology, heath, diseases and medicine has become increasingly evident over the last three decades or more. The inorganic aspects of life processes and biological processes can be understood from the viewpoint of the coordination chemistry of metal ions. The study of metal ions in biological systems can only be appreciated from a multidisciplinary approach. It stays within the rapidly growing interface between inorganic chemistry and the living world. It is increasingly recognized that selected metal ions are involved in cellular and subcellular functions.

Intended audience: MSc, MTech and MPharm

Prerequisites: 1. Coordination Chemistry 2. Basic Bioinorganic Chemistry

Lectures

Week 1

  1. Lecture 01 - Metal Ions In Biological Systems YouTube
  2. Lecture 02 - Metallobiosite structures YouTube
  3. Lecture 03 - Biomolecular structure and molecular biology component YouTube
  4. Lecture 04 - Structures of nucleic acids YouTube
  5. Lecture 05 - Coordination Chemistry in action YouTube

Week 2

  1. Lecture 06 : Coordination of peptide building blocks YouTube
  2. Lecture 07 : Occurrence and availability YouTube
  3. Lecturer 08 : Potential ligands of different types YouTube
  4. Lecture 09 : Metal ion insertion YouTube
  5. Lecture 10 : Organic cofactors and siderophores YouTube

Week 3

  1. Lecture 11 : Introduction YouTube
  2. Lecture 12 : CD and Raman spectroscopy YouTube
  3. Lecture 13 : EPR YouTube
  4. Lecture 14 : NMR and X-ray YouTube
  5. Lecture 15 : Electrochemical methods YouTube

Week 4

  1. Lecture 16 : Metal ion assimilation YouTube
  2. Lecture 17 : Transport of metal ions in bacteria and plants YouTube
  3. Lecture 18 : Transport of metal ions in fungi and mammals YouTube
  4. Lecture 19 : Homeostasis in bacteria and plants YouTube
  5. Lecture 20 : Homeostasis in fungi and mammals YouTube

Week 5

  1. Lecture 21 : Transport across membranes YouTube
  2. Lecture 22 : Ion channels and ion pumps YouTube
  3. Lecture 23 : K+ channels YouTube
  4. Lecture 24 : Na+ channels YouTube
  5. Lecture 25 : Na+-K+ ATPase YouTube

Week 6

  1. Lecture - 26 : Mg2+ dependent enzymes and kinases YouTube
  2. Lecture - 27 : Phosphatases & enolases YouTube
  3. Lecture - 28 : Photoreception and enzymes YouTube
  4. Lecture - 29 : Ca2+ transporting, binding and sensor proteins YouTube
  5. Lecture - 30 : Cell signaling by Ca2+ binding and sensing YouTube

Week 7

  1. Lecture - 31 : Functions of iron ions and iron ion proteins YouTube
  2. Lecture - 32 : Heme proteins for O2 transport and storage YouTube
  3. Lecture - 33 : Activators of O2 and electron transport proteins YouTube
  4. Lecture - 34 : Iron-sulfur proteins YouTube
  5. Lecture - 35 : Mononuclear and dinuclear non-heme enzymes YouTube

Week 8

  1. Lecture - 36 : Oxygen transport and SOD activity YouTube
  2. Lecture - 37 : Type 1 blue copper proteins YouTube
  3. Lecture - 38 : Type 2 non-blue copper proteins YouTube
  4. Lecture - 39 : Type 3 dinuclear copper proteins YouTube
  5. Lecture - 40 : Multicopper and mixed-copper enzymes YouTube

Week 9

  1. Lecture - 41 : Coordination chemistry and function of zinc ions YouTube
  2. Lecture - 42 : Carbonic anhydrase and lyases YouTube
  3. Lecture - 43 : Carboxypeptidase and metalloproteinases YouTube
  4. Lecture - 44 : Alcohol dehydrogenase and bita -lactamase YouTube
  5. Lecture - 45 : Alkaline phosphatase and adenosine deaminase YouTube

Week 10

  1. Lecture - 46 : Redox catalysis by manganese ions YouTube
  2. Lecture - 47 : Catalysis by manganese and cobalt ions YouTube
  3. Lecture - 48 : Cobalt ion dependent proteins and enzymes YouTube
  4. Lecture - 49 : Nickel proteins and enzymes YouTube
  5. Lecture - 50 : More nickel ion bearing enzymes YouTube

Week 11

  1. Lecture - 51 : Carbon, hydrogen and oxygen YouTube
  2. Lecture - 52 : Nitrogen and Silicon YouTube
  3. Lecture - 53 : Phosphorus YouTube
  4. Lecture - 54 : Sulfur and Selenium YouTube
  5. Lecture - 55 : Chlorine and Iodine YouTube

Week 12

  1. Lecture - 56 : Brain & blood-brain barrier (BBB) YouTube
  2. Lecture - 57 : Zinc and copper ions YouTube
  3. Lecture - 58 : Iron ions YouTube
  4. Lecture - 59 : Metal ion based drugs and metallotherapeutics YouTube
  5. Lecture - 60 : Chemotherapy, radiotherapy and contrast agents YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Kharagpur
Department
Chemistry and Biochemistry
Teacher
Prof. Debashis Ray
Level
Graduate
Language
English
Subjects
Chemistry
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
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