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Course10410512740 lectures

Structure, Stereochemistry and Reactivity of Organic Compounds and Intermediates: A Problem-solving Approach

Prof. Amit Basak · IIT Kharagpur

Start with lecture 1 At NPTEL

Lectures

Module 01:

  1. Lecture 01: Introduction to structure and stereochemistry of organic molecules: salient features of symmetry elements; Role of principal axis, sigma plane, centre of symmetry, and alternating axis of symmetry in deciding chirality Video
  2. Lecture 02: Introduction to point group notation, classification, symmetry number and order Video
  3. Lecture 03: Examples of various point group notations, chiral and achiral point groups, examples of various point groups Video
  4. Lecture 04: Solving problems on point groups (Cn, Cnv, Cnh, Dnd) Video
  5. Lecture 05: Conformational Analysis of Perhydrophenanthrene Video
  6. Lecture 06: Concept Clearing Session on Achiral Point Groups Video

Module 02:

  1. Lecture 07: Axial, Planar and Helical Chirality, assignment of absolute configuration to such molecules Video
  2. Lecture 08: Concept of pseudoasymmetry; Reflection variance/invariance problem; methods of nomenclature system Video
  3. Lecture 09: Conformational analysis of bicyclic systems: the Decalins Video
  4. Lecture 10: Conformational analysis of Perhydrophenanthrene Video
  5. Lecture 11: Conformational analysis of Perhydroanthracene Video
  6. Lecture 12: Revisiting conformational analysis of Perhydrophenanthrene Video
  7. Lecture 13: Revisiting conformational analysis of Perhydroanthracene Video

Module 03:

  1. Lecture 14: Introduction to Linear Polarized light and interaction with chiral materials; Circular Birefringence, Circular Dichroism Video
  2. Lecture 15: ORD, CD and Cotton Effect (CE); Empirical rule to determine the sign of CE, 2-axial haloketone rule Video
  3. Lecture 16: Octant rule: application to substituted cyclohexanone and decalone system Video
  4. Lecture 17: Application of Octant rule to tricyclic system; drawing of octant projection Video
  5. Lecture 18: Application of Octant rule to steroidal ketones; drawing of octant projection Video

Module 04:

  1. Lecture 19: Stereoelectronic effects on conformation and reactivity Video
  2. Lecture 20: Examples of anomeric effect and Stereoelectronic effect Video
  3. Lecture 21: Baldwin rules Video
  4. Lecture 22: Cyclization in enolic systems Video
  5. Lecture 23: Problem solving on Baldwin rules Video

Module 05:

  1. Lecture 24: Reactive Functionalities: Chemistry of Alkynes Video
  2. Lecture 25: Reactive Functionalities: Chemistry of Alkynes (contd), arynes and enediynes Video
  3. Lecture 26: Reactive Functionalities: Enediynes (contd), allenes and Ketenes Video
  4. Lecture 27: Beta - Lactam Synthesis Video

Module 06:

  1. Lecture 28: Chemistry of radicals Video
  2. Lecture 29: Reactivity of radicals: Frontier orbital approach. Video
  3. Lecture 30: Radical mediated C-C bond formation. Video
  4. Lecture 31: Radical mediated C-C bond formation (contd). Video
  5. Lecture 32: Radical mediated decarboxylation and deoxygenation Video

Module 07:

  1. Lecture 33: Dynamic Stereochemistry: Conformationally rigid and mobile systems Video
  2. Lecture 34: Dynamic Stereochemistry: Conformational analysis of elimination and addition Video
  3. Lecture 35: Dynamic Stereochemistry: Stereoselectivity in carbonyl reduction Video
  4. Lecture 36: Dynamic Stereochemistry: Reactivity of unsaturated carbonyl and enolate systems Video

Module 08:

  1. Lecture 37: Dynamic Stereochemistry: Enolate as nucleophile Video
  2. Lecture 38: Dynamic Stereochemistry: stereochemical issues in cyclohexenone reduction and alpha-electrophilic substitution in carbonyls Video
  3. Lecture 39: Dynamic Stereochemistry: Asymmetric aldol reactions Video
  4. Lecture 40: Dynamic Stereochemistry: Asymmetric aldol reaction (Contd) Video

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Kharagpur
Department
Chemistry and Biochemistry
Teacher
Prof. Amit Basak
Level
Undergraduate
Language
English
Subjects
Chemistry
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
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