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Course10410113560 lectures

NMR Spectroscopy for Structural Biology

Prof. Ashutosh Kumar and Prof. R. V Hosur · IIT Bombay

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About

This course will start with Basic principles of NMR, Discuss practical aspects of NMR spectroscopy, peptide NMR, Protein NMR, Nucleic acids NMR. We will teach with examples how to solve structure and measure dynamics using NMR.

Intended audience: M.Sc./ PhD students & Scientist, and Scientists working in Biopharma Industries.

Prerequisites: Under graduate level understanding of Physics and Mathematics, Basic course on NMR spectroscopy.INTENDED AUDIENCE: M.Sc./ PhD students & Scientist, and Scientists working in Biopharma Industries.

Lectures

Week 1

  1. Lecture 1 : NMR Basic Concepts - I YouTube
  2. Lecture 2 : NMR Basic Concepts - II YouTube
  3. Lecture 3 : NMR Basic Concepts - III YouTube
  4. Lecture 4 : NMR Basic Concepts - IV YouTube
  5. Lecture 5 : NMR Spectra of Molecules YouTube

Week 2

  1. Lecture 6 : Chemical Shifts and Coupling constant YouTube
  2. Lecture 7 : Fine Structures in NMR Spectra YouTube
  3. Lecture 8 : Pulse Excitation and FT-NMR YouTube
  4. Lecture 9 : Practical Aspects of FT-NMR - I YouTube
  5. Lecture 10 : Practical Aspects of FT-NMR - II YouTube

Week 3

  1. Lecture 11 : Practical Aspects of FT-NMR 3 YouTube
  2. Lecture 12 : Practical Aspects of FT-NMR 4 YouTube
  3. Lecture 13 : Polarization Transfer Technique YouTube
  4. Lecture 14 : Polarization Transfer Technique 2 YouTube
  5. Lecture 15 : General Concept of Multidimensional NMR 1 YouTube

Week 4

  1. Lecture 16 : General Concept of Multidimensional NMR 2 YouTube
  2. Lecture 17 : 2-D NMR or 2-D Co-relation spectroscopy : General concept 1 YouTube
  3. Lecture 18 : 2-D NMR or 2-D Co-relation spectroscopy : General concept 2 YouTube
  4. Lecture 19 : 2-D NMR or 2-D Co-relation spectroscopy : General concept 3 YouTube
  5. Lecture 20 : Introduction to NOESY and HSQC 1 YouTube

Week 5

  1. Lecture 21 : Introduction to NOESY and HSQC 2 YouTube
  2. Lecture 22 : Introduction to NOESY and HSQC 3 YouTube
  3. Lecture 23 : Introduction to NOESY and HSQC 4 YouTube
  4. Lecture 24 : Application of NMR in the area of structural Biology: Structure of DNA and RNA 1 YouTube
  5. Lecture 25 : Application of NMR in the area of structural Biology: Structure of DNA and RNA 2 YouTube

Week 6

  1. Lecture 26 : Application of NMR in the area of structural Biology: Structure of DNA and RNA 3 YouTube
  2. Lecture 27 : Application of NMR in the area of structural Biology: Structure of DNA and RNA 4 YouTube
  3. Lecture 28 : Application of NMR in the area of structural Biology: Structure of DNA and RNA 5 YouTube
  4. Lecture 29 : Application of NMR in the area of structural Biology: Structure of DNA and RNA 6 YouTube
  5. Lecture 30 : Application of NMR in the area of structural Biology: Structure of DNA and RNA 7 YouTube

Week 7

  1. Lecture 31 : Determination of Structure and Dynamics of Proteins-1 YouTube
  2. Lecture 32 : Determination of Structure and Dynamics of Proteins-2 YouTube
  3. Lecture 33 : Determination of Structure and Dynamics of Proteins-3 YouTube
  4. Lecture 34 : Determination of Structure and Dynamics of Proteins-4 YouTube
  5. Lecture 35 : Determination of Structure and Dynamics of Proteins-5 YouTube

Week 8

  1. Lecture 36 : Determination of Structure and Dynamics of Proteins-6 YouTube
  2. Lecture 37 : NMR Analysis of Protein Dynamics I YouTube
  3. Lecture 38 : NMR Analysis of Protein Dynamics II YouTube
  4. Lecture 39 : NMR Analysis of Protein Dynamics III YouTube
  5. Lecture 40 : NMR Analysis of Protein Dynamics IV YouTube

Week 9

  1. Lecture 41 : Protein-Ligand and Protein-Protein Interaction YouTube
  2. Lecture 42 : NMR Analysis of Ligand specific parameters in a Protein-Ligand Interaction I YouTube
  3. Lecture 43 : NMR Analysis of Ligand specific parameters in a Protein-Ligand Interaction II YouTube
  4. Lecture 44 : NMR Analysis of Protein Specific Parameters in a Protein-Ligand Interaction I YouTube
  5. Lecture 45 : NMR Analysis of Protein Specific Parameters in a Protein-Ligand Interaction II YouTube

Week 10

  1. Lecture 46 : NMR in Drug Design YouTube
  2. Lecture 47 : NMR in Drug Discovery YouTube
  3. Lecture 48 : NMR in Drug metabolism I YouTube
  4. Lecture 49 : NMR in Drug metabolism II YouTube
  5. Lecture 50 : NMR in Drug metabolism III YouTube

Week 11

  1. Lecture 51 : Probing Protein Dynamics by NMR Spectroscopy I YouTube
  2. Lecture 52 : Probing Protein Dynamics by NMR Spectroscopy II YouTube
  3. Lecture 53 : Probing Protein Dynamics by NMR Spectroscopy III YouTube
  4. Lecture 54 : Probing Protein Dynamics by NMR Spectroscopy IV YouTube
  5. Lecture 55 : Probing Protein Dynamics by NMR Spectroscopy V YouTube

Week 12

  1. Lecture 56 : Basics of solid state NMR spectroscopy - I YouTube
  2. Lecture 57 : Basics of solid state NMR spectroscopy - II YouTube
  3. Lecture 58 : Basics of solid state NMR spectroscopy - III YouTube
  4. Lecture 59 : Basics of solid state NMR spectroscopy - IV YouTube
  5. Lecture 60 : Basics of solid state NMR spectroscopy - V YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Bombay
Department
Chemistry and Biochemistry
Taught by
Prof. Ashutosh Kumar, Prof. R. V Hosur
Level
Graduate
Language
English
Subjects
Chemistry
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
Who can watch
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