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Course10410113358 lectures

Classics in Total Synthesis - I

Prof. Krishna P Kaliappan · IIT Bombay

Start with lecture 1 At NPTEL

About

Some of the classical total synthesis of natural and unnatural products reported between 1950-2000 will be discussed in details. This course will be ideal for 2nd year MSc students and 1st year Ph.D students. This course will be followed by part-II where some important total synthesis of natural products disclosed between 2001 to-date will be discussed.

Intended audience: Chemistry Masters students/Chemistry PhD students.

Prerequisites: BSc and MSc (1st year)INTENDED AUDIENCE: Chemistry Masters students/Chemistry PhD students.

Lectures

Week 1

  1. Lecture 1: Overview- 1 YouTube
  2. Lecture 2: Overview-2 YouTube
  3. Lecture 3: Overview -3 YouTube
  4. Lecture 4: Illudin M(Kinder) Illudin C (Funk) YouTube
  5. Lecture 5: FR900848 (Barrett) YouTube

Week 2

  1. Lecture 6: Cubane YouTube
  2. Lecture 7: Endiandric Acids YouTube
  3. Lecture 8: Penicillin (Sheehan) YouTube
  4. Lecture 9: Thienamycin (Merck) YouTube
  5. Lecture 10: Prostaglandin (Corey) YouTube

Week 3

  1. Lecture 11: Prostaglandin (Johnson and Stork) YouTube
  2. Lecture 12: Biotin & Lactacystin (i) Corey, ii) Baldwin) YouTube
  3. Lecture 13: Triquinanes: Isocomene 1) M. Pirrung 2) Fitjer YouTube
  4. Lecture 14: Triquinanes: αβ -Isocomene and Silphipherfol-6-en-5-one (Rawal) YouTube
  5. Lecture 15: Triquinanes by radical cyclisation: Hirsutene&Capnellene (Curran) YouTube

Week 4

  1. Lecture 16: Triquinanes by radical cyclisation: Silphiperfolene&Modhephene (Curran) YouTube
  2. Lecture 17: Triquinanes by photochemical reaction (Demuth & Uyehara YouTube
  3. Lecture 18: Triquinanes by photochemical reaction (Oda, Wender&Chanon) YouTube
  4. Lecture 19: Triquinanes by Thermal Metathesis (Mehta) YouTube
  5. Lecture 20: Triquinanes by other reactions YouTube

Week 5

  1. Lecture 21: Longifolene YouTube
  2. Lecture 22: Carpanone YouTube
  3. Lecture 23: Mevinolin YouTube
  4. Lecture 24: Gibberellic acid (Corey) YouTube

Week 6

  1. Lecture 25: Gibberellic acid by Yamada YouTube
  2. Lecture 26: Perhydrohistrionicotoxin YouTube
  3. Lecture 27: Strychnine (Woodward) YouTube
  4. Lecture 28: Strychnine (1) Rawal, 2) Overman) YouTube
  5. Lecture 29: Strychnine (Kuehne) YouTube

Week 7

  1. Lecture 30: Reserpine (Woodward) YouTube
  2. Lecture 31: Yohimbine YouTube
  3. Lecture 32: Quinine YouTube
  4. Lecture 33: Dendrobine YouTube
  5. Lecture 34: Morphine (Gates) YouTube

Week 8

  1. Lecture 35: Morphine (Parker & White) YouTube
  2. Lecture 36: Methylhomosecodaphniphyllate & Secodaphnyphillane YouTube
  3. Lecture 37: Lysergic acid YouTube
  4. Lecture 38: Galanthamine YouTube
  5. Lecture 39: Epibatidine YouTube

Week 9

  1. Lecture 40: Swainsonine YouTube
  2. Lecture 41: Staurosporine YouTube
  3. Lecture 42: Manzamine A YouTube
  4. Lecture 43: Progesterone YouTube
  5. Lecture 44: Steroids YouTube

Week 10

  1. Lecture 45: Estrone YouTube
  2. Lecture 46: Taxol (Nicolaou) YouTube
  3. Lecture 47: Taxol (Holton) YouTube
  4. Lecture 48: Taxol (Danishefsky) YouTube
  5. Lecture 49: Taxol (Wender) YouTube

Week 11

  1. Lecture 50: Eleutherobin (Nicolaou) YouTube
  2. Lecture 51: Eleutherobin (Danishefsky) YouTube
  3. Lecture 52: Phorbol (Wender) YouTube
  4. Lecture 53: Periplanone YouTube
  5. Lecture 54: Discodermolide YouTube

Week 12

  1. Lecture 55: Epothilones by Nicolaou YouTube
  2. Lecture 56: Epothilones by 1.Schinzer 2. Danishefsky YouTube
  3. Lecture 57: Vineomycinone B2 YouTube
  4. Lecture 58: Zaragozic Acid C YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Bombay
Department
Chemistry and Biochemistry
Teacher
Prof. Krishna P Kaliappan
Level
Graduate
Language
English
Subjects
Chemistry
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
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