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Course10410111760 lectures

NMR Spectroscopy for Chemists and Biologists

Prof. Ashutosh Kumar and Prof. R. V Hosur · IIT Bombay

Start with lecture 1 At NPTEL

About

This course will start with Basic principles of NMR, walk through the analysis of spectra and demonstrate the application of multidimensional NMR spectroscopy in Chemistry and structural Biology.

INTENDED AUDIENCE: M. Sc./ PhD and Scientists working in Pharma and Biopharma Industries

PREREQUISITES: Under graduate level understanding of Physics and Mathematics

INDUSTRY SUPPORT : Biocon, Wockhardt, Aurobindo Biopharma etc

Lectures

Week 1 - Basic Concepts in NMR

  1. Lecture 1 : Basic concepts YouTube
  2. Lecture 2 : Resonance absorption YouTube
  3. Lecture 3 : Bloch Equations YouTube
  4. Lecture 4 : Relaxation YouTube
  5. Lecture 5 : Introduction to Chemical Shift YouTube

Week 2 - High Resolution NMR Spectra of Molecules

  1. Lecture 6 : Factors affecting Isotropic Chemical Shifts YouTube
  2. Lecture 7 : Spin-Spin Coupling YouTube
  3. Lecture 8 : Interpretation of multiplet structure using first order analysis YouTube
  4. Lecture 9 : Analysis of NMR spectra of molecules YouTube
  5. Lecture 10 : Quantum Mechanical Analysis-Part I YouTube

Week 3 - Fourier Transform NMR

  1. Lecture 11 : Quantum Mechanical Analysis-Part I I YouTube
  2. Lecture 12 : Dynamic effects in the NMR Spectra YouTube
  3. Lecture 13 : Fourier Transform NMR YouTube
  4. Lecture 14 : Theorems on Fourier Transform YouTube
  5. Lecture 15 : Practical aspects of Fourier Transform NMR spectra YouTube

Week 4 Fourier Transform NMR (continued)

  1. Lecture 16 : Data Processing in Fourier Transform NMR YouTube
  2. Lecture 17 : Dynamic range in Fourier Transform NMR YouTube
  3. Lecture 18 : Spin Echo and Solvent Suppression YouTube
  4. Lecture 19 : Spin Decoupling in FT NMR and Relaxation Measurements YouTube
  5. Lecture 20 : Polarization Transfer YouTube

Week 5 - Polarization Transfer

  1. Lecture 21 : Nuclear Overhauser Effect YouTube
  2. Lecture 22 : Steady state NOE and Transient NOE YouTube
  3. Lecture 23 : Distance and NOE YouTube
  4. Lecture 24 : Selective Population Inversion YouTube
  5. Lecture 25 : INEPT and Sensitivity Enhancement YouTube

Week 6

  1. Lecture 26 : Rotating Frame Experiments YouTube
  2. Lecture 27 : Density matrix description of NMR - I YouTube
  3. Lecture 28 : Density matrix description of NMR - II YouTube
  4. Lecture 29 : Density matrix description of NMR - III YouTube
  5. Lecture 30 : Time evolution of density operator YouTube

Week 7 - Product Operator Formalism

  1. Lecture 31 : Density matrix description of NMR - IV YouTube
  2. Lecture 32 : Evolution of density operator in the presence of RF YouTube
  3. Lecture 33 : Product operator formalism YouTube
  4. Lecture 34 : Product operator formalism Continued YouTube
  5. Lecture 35 : Product operator formalism Continued YouTube

Week 8 - Basis Operators and Spin Echo

  1. Lecture 36 : Time evolution of basis operators YouTube
  2. Lecture 37 : Observable and Non-observable basis operators, Spin echo YouTube
  3. Lecture 38 : Spin echo Continued YouTube
  4. Lecture 39 : INEPT YouTube
  5. Lecture 40 : Multidimensional NMR Spectroscopy YouTube

Week 9 - Two Dimensional NMR Spectroscopy

  1. Lecture 41 : Two Dimensional NMR- Part I YouTube
  2. Lecture 42 : Two Dimensional NMR- Part II YouTube
  3. Lecture 43 : Types of 2D NMR Spectra YouTube
  4. Lecture 44 : Two Dimensional Separation of Interaction in NMR YouTube
  5. Lecture 45 : Two Dimensional Correlation Experiments YouTube

Week 10 - Two Dimensional Correlation Experiments

  1. Lecture 46 : Two Dimensional Correlation Experiments II YouTube
  2. Lecture 47 : Two Dimensional Correlation Experiments III YouTube
  3. Lecture 48 : Double Quantum Filtered COSY (DQF-COSY) YouTube
  4. Lecture 49 : Two Dimensional Nuclear Overhauser Effect Spectroscopy (2D- NOESY) YouTube
  5. Lecture 50 : Constant-time COSY YouTube

Week 11 - 2D Heteronuclear Experiments

  1. Lecture 51 : Scaling in 2D NMR YouTube
  2. Lecture 52 : Total Correlation Spectroscopy YouTube
  3. Lecture 53 : 2D Heteronuclear Experiment I YouTube
  4. Lecture 54 : 2D Heteronuclear Experiment II YouTube
  5. Lecture 55 : Multidimensional NMR YouTube

Week 12 - Peptide Structure Determination and Protein-Ligand Interaction

  1. Lecture 56: Structure Determination of Peptides by NMR- I YouTube
  2. Lecture 57: Structure Determination of Peptides by NMR- II YouTube
  3. Lecture 58: Protein-Ligand Interaction- I YouTube
  4. Lecture 59: Protein-Ligand Interaction- II YouTube
  5. Lecture 60: Diffusion Ordered Spectroscopy YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Bombay
Department
Chemistry and Biochemistry
Taught by
Prof. Ashutosh Kumar, Prof. R. V Hosur
Level
Graduate
Language
English
Subjects
Chemistry
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
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