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Metals In Biology

Prof. D. Maiti · IIT Bombay

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About

Metals are the vital component of any biosystem. Starting from transporting biochemicals to catalyzing biochemical transformations, almost every process requires presence of a metal center. In order to understand these processes knowledge of specific functions carried out by these metals are necessary. This course will be helpful to understand the fundamental properties of the metals present in biosystems and mechanism of their action.

INTENDED AUDIENCE : Chemistry, Biochemistry Students/faculty

Lectures

Week 1

  1. Lecture 1 : Importance of metals in biology YouTube
  2. Lecture 2 : Choice, uptake and assembly of metal ions in cells YouTube
  3. Lecture 3 : Control and use of metal ions concentration in biological systems YouTube
  4. Lecture 4 : Metal mediated folding of biopolymers YouTube
  5. Lecture 5 : Study of binding mode of calcium and zinc in proteins YouTube

Week 2

  1. Lecture 6 : Electron transfer (ET) in living systems YouTube
  2. Lecture 7 : Oxygen transport and activation YouTube
  3. Lecture 8 : Hydrolytic Enzymes- Part I-Carbonic anhydrase & Liver alcohol dehydrogenase YouTube
  4. Lecture 9 : Hydrolytic Enzymes- Part II-Carbopeptidase YouTube
  5. Lecture 10 : Hydrolytic Enzymes- Part III-Arginase & Urease YouTube

Week 3

  1. Lecture 11 : Hemerythrin and azidomethemerythrin YouTube
  2. Lecture 12 : Dioxygen reactivity in copper YouTube
  3. Lecture 13 : Cu-O2 intermediates YouTube
  4. Lecture 14 : Copper-Oxygen chemistry- Part I-Mononuclear copper-oxygen YouTube
  5. Lecture 15 : Copper-Oxygen chemistry- Part II-Cu-O2 complexes YouTube

Week 4

  1. Lecture 16 : Copper-Oxygen chemistry- Part III - Reactivity summary YouTube
  2. Lecture 17 : Iron Catalyzed oxidation of unactivated sp3 C-H bonds-Part I YouTube
  3. Lecture 18 : Iron catalyzed oxidation of unactivated sp3 C-H bonds-Part II YouTube
  4. Lecture 19 : Iron catalyzed oxidation of unactivated sp3 C-H bonds-Part III YouTube
  5. Lecture 20 : Nitrous oxide reductase and its model complex YouTube

Week 5

  1. Lecture 21 : Cytochrome C-oxidase YouTube
  2. Lecture 22 : Systematic variations in O-O stretch in Iron-oxo-copper ligand complex YouTube
  3. Lecture 23 : Mononuclear nonheme iron (NHI) enzymes YouTube
  4. Lecture 24 : Alpha-Keto Glutarate dependent Halogenases YouTube
  5. Lecture 25 : Cytochrome P450-Part I-Introduction YouTube

Week 6

  1. Lecture 26 : Cytochrome P450-Part II-Reactions YouTube
  2. Lecture 27 : Cytochrome P450-Part III- Mechanism YouTube
  3. Lecture 28 : Cytochrome P450- Part IV- Role of Cystine ligand and distal charge relay YouTube
  4. Lecture 29 : Methane monooxygenase YouTube
  5. Lecture 30 : Dinuclear Iron active sites for CH4 to CH4OH conversion & its Mechanism YouTube

Week 7

  1. Lecture 31 : Concerted Vs radical pathway for CH4 to CH4OH conversion YouTube
  2. Lecture 32 : Photosynthesis Part I YouTube
  3. Lecture 33 : Photosynthesis Part II YouTube
  4. Lecture 34 : Pumps and channels YouTube
  5. Lecture 35 : Quick summary on O2 transport YouTube

Week 8

  1. Lecture 36 : Summary of Dioxygen reactivity in copper YouTube
  2. Lecture 37 : Summary of Dioxygen reactivity in iron YouTube
  3. Lecture 38 : Summary of Fe-O2 chemistry YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Bombay
Department
Chemistry and Biochemistry
Teacher
Prof. D. Maiti
Level
Undergraduate
Language
English
Subjects
Chemistry
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
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