Course10410111540 lectures
Mechanisms in Organic Chemistry
Prof. Nandita Madhavan · IIT Bombay
About
The course can be broadly classified as a Physical Organic Chemistry course. Understanding organic reaction mechanisms are extremely useful in predicting the products and improving the reaction efficiency. A student needs to know basic concepts in order to be able to write reasonable reaction mechanisms. A mechanism cannot be considered valid unless there is experimental evidence to support it. The student needs to know basic experiments that can be used to validate reaction mechanisms. Learning outcomes for the course: At the end of the course, the student should be able to • Propose/write a mechanism for a given organic reaction. • Design experiments to determine reaction intermediates/mechanisms.
INTENDED AUDIENCE : Students studying Chemistry
PREREQUISITES : Basic Organic Chemistry
Lectures
Week 1
- Lecture 1 : Introduction to Reaction Mechanisms
- Lecture 2 : Writing Reaction Mechanisms: Arrow pushing
- Lecture 3 : Types of Polar Reactions
- Lecture 4 : The Radical Reactions
Week 2
- Lecture 5 : Reaction Co-ordinate Diagrams
- Lecture 6 : The Hammond Postulate
- Lecture 7 : Kinetic versus Thermodynamic Control
- Lecture 8 : Curtin-Hammett Principle
- Lecture 9 : An Introduction to Reaction Kinetics
Week 3
- Lecture 10 : Deriving the Rate Laws
- Lecture 11 : Distinguishing Reaction Mechanisms Using Rate Laws
- Lecture 12 : Methods to Monitor a Reaction
- Lecture 13 : The Hammett Equation
- Lecture 14 : Linear Free Energy Relationships (LFER)
Week 4
- Lecture 15 : Hammett Plots for Electronic Effects
- Lecture 16 : Scales used in Hammett Plots
- Lecture 17 : Deviation from Linear Free Energy Relationships
- Lecture 18 : LFER for Sterics: The Taft Parameters
- Lecture 19 : Solvent Effects: Part A
Week 5
- Lecture 20 : Solvent Effects: Part B
- Lecture 21 : Kinetic Isotope Effect
- Lecture 22 : Primary Kinetic Isotope Effect
- Lecture 23 : Secondary Kinetic Isotope Effect: Part A
- Lecture 24 : Secondary Kinetic Isotope Effect: Part B
Week 6
- Lecture 25 : Heavy Atom Isotope Effects
- Lecture 26 : Equilibrium Isotope Effects
- Lecture 27 : Isotope Labelling
- Lecture 28 : Trapping Intermediates: Part A
- Lecture 29 : Trapping Intermediates: Part B
Week 7
- Lecture 30 : Trapping Intermediates: Part C
- Lecture 31 : Checking for Common Intermediates
- Lecture 32 : Catalysis: Part A
- Lecture 33 : Catalysis: Part B
- Lecture 34 : Specific Catalysis
Week 8
Syllabus and materials
At NPTEL, as the course publishes them.
Credits and licence
- Institution
- IIT Bombay
- Department
- Chemistry and Biochemistry
- Teacher
- Prof. Nandita Madhavan
- Level
- Undergraduate
- Language
- English
- Subjects
- Chemistry
- Source
- NPTEL
- Licence
- CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
- Attribution
- NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
- Who can watch
- NPTEL gives no rating. Invisible Network shows it to Tweens profiles and older, judged from what the source says about it. How courses are placed