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Course10210508960 lectures

Fundamentals of Protein Chemistry

Prof. Swagata Dasgupta · IIT Kharagpur

Start with lecture 1 At NPTEL

About

The course provides an in-depth study into protein structure and function. Building up from an understanding of amino acids and the peptide bond that form the basics of protein structure, protein folding and denaturation will be studied followed by the techniques used for protein isolation and characterization. The importance of metalloproteins and motor proteins will be followed by a discussion on membrane proteins and transport. Important aspects of enzymes, their mechanisms, kinetics and inhibition will be looked into with specific examples. The discussion on protein interactions will cover protein-ligand and protein-protein interactions. Finally some special topics in Protein Chemistry will be discussed relevant to current literature.

Intended audience: Undergraduate and Graduate students

Prerequisites: Biochemistry

Lectures

Week 1

  1. Lecture 01 : Amino Acids - I YouTube
  2. Lecture 02 : Amino Acids - II YouTube
  3. Lecture 03 : Amino Acids - III YouTube
  4. Lecture 04 : The Peptide Bond YouTube
  5. Lecture 05 : Discussion Class YouTube

Week 2

  1. Lecture 06 : Primary Structure YouTube
  2. Lecture 07 : Secondary Structure YouTube
  3. Lecture 08 : Tertiary and Quaternary Structure YouTube
  4. Lecture 09 : Protein Interactions YouTube
  5. Lecture 10 : Discussion Class YouTube

Week 3

  1. Lecture 11 : Protein folding and structure YouTube
  2. Lecture 12 : Thermodynamics of Protein Folding YouTube
  3. Lecture 13 : Protein Structure Methods YouTube
  4. Lecture 14 : Protein Denaturation YouTube
  5. Lecture 15 : Discussion Class YouTube

Week 4

  1. Lecture 16 : Protein Isolation Methods YouTube
  2. Lecture 17 : Protein Purification YouTube
  3. Lecture 18 : Biophysical Methods - I YouTube
  4. Lecture 19 : Biophysical Methods - II YouTube
  5. Lecture 20 : Biophysical Methods III YouTube

Week 5

  1. Lecture 21 : Types of Protein ligand interactions YouTube
  2. Lecture 22 : Kinetics and Thermodynamics of protein-ligand binding YouTube
  3. Lecture 23 : Experimental methods in protein ligand interactions YouTube
  4. Lecture 24 : Protein ligand docking YouTube
  5. Lecture 25 : Discussion class YouTube

Week 6

  1. Lecture 26 : Enzymes I: Classification YouTube
  2. Lecture 27 : Enzymes - II YouTube
  3. Lecture 28 : Enzyme Mechanisms - I YouTube
  4. Lecture 29 : Enzyme Mechanisms - II YouTube
  5. Lecture 30 : Enzyme mechanisms - III YouTube

Week 7

  1. Lecture 31 : Enzyme Kinetics - I YouTube
  2. Lecture 32 : Enzyme Kinetics - II YouTube
  3. Lecture 33 : Enzyme Inhibition - I YouTube
  4. Lecture 34 : Enzyme Inhibition - II YouTube
  5. Lecture 35 : Discussion class YouTube

Week 8

  1. Lecture 36 : Motor Proteins - I YouTube
  2. Lecture 37 : Motor Proteins - II YouTube
  3. Lecture 38 : Metalloproteins - I YouTube
  4. Lecture 39 : Metalloproteins - II YouTube
  5. Lecture 40 : Myoglobin and Hemoglobin YouTube

Week 9

  1. Lecture 41 : Membrane Proteins - I YouTube
  2. Lecture 42 : Membrane proteins - II YouTube
  3. Lecture 43 : Membrane Transport - I YouTube
  4. Lecture 44 : Membrane Transport - II YouTube
  5. Lecture 45 : Electron Transport Chain YouTube

Week 10

  1. Lecture 46 : Protein Carbohydrate Interactions - I YouTube
  2. Lecture 47 : Protein Carbohydrate Interactions - II YouTube
  3. Lecture 48 : Protein Nucleic Acid Interactions - I YouTube
  4. Lecture 49 : Protein Nucleic Acid Interactions - II YouTube
  5. Lecture 50 : Protein Nucleic Acid Interactions - III YouTube

Week 11

  1. Lecture 51 : Protein Protein Interactions - I YouTube
  2. Lecture 52 : Protein Protein Interactions - II YouTube
  3. Lecture 53 : Protein Peptide Interactions YouTube
  4. Lecture 54 : Chaperone proteins YouTube
  5. Lecture 55 : Protein Nanoparticle Interactions YouTube

Week 12

  1. Lecture 56 : Oxidative stress in Proteins YouTube
  2. Lecture 57 : Enzyme action and Proteolytic cleavage YouTube
  3. Lecture 58 : Intrinsically disordered proteins YouTube
  4. Lecture 59 : Viral proteins YouTube
  5. Lecture 60 : Overview of Course YouTube

Syllabus and materials

At NPTEL, as the course publishes them.

Credits and licence

Institution
IIT Kharagpur
Department
Chemistry and Biochemistry
Teacher
Prof. Swagata Dasgupta
Level
Undergraduate
Language
English
Subjects
Chemistry
Source
NPTEL
Licence
CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
Attribution
NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
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