Course10210508960 lectures
Fundamentals of Protein Chemistry
Prof. Swagata Dasgupta · IIT Kharagpur
About
The course provides an in-depth study into protein structure and function. Building up from an understanding of amino acids and the peptide bond that form the basics of protein structure, protein folding and denaturation will be studied followed by the techniques used for protein isolation and characterization. The importance of metalloproteins and motor proteins will be followed by a discussion on membrane proteins and transport. Important aspects of enzymes, their mechanisms, kinetics and inhibition will be looked into with specific examples. The discussion on protein interactions will cover protein-ligand and protein-protein interactions. Finally some special topics in Protein Chemistry will be discussed relevant to current literature.
Intended audience: Undergraduate and Graduate students
Prerequisites: Biochemistry
Lectures
Week 1
- Lecture 01 : Amino Acids - I
- Lecture 02 : Amino Acids - II
- Lecture 03 : Amino Acids - III
- Lecture 04 : The Peptide Bond
- Lecture 05 : Discussion Class
Week 2
- Lecture 06 : Primary Structure
- Lecture 07 : Secondary Structure
- Lecture 08 : Tertiary and Quaternary Structure
- Lecture 09 : Protein Interactions
- Lecture 10 : Discussion Class
Week 3
- Lecture 11 : Protein folding and structure
- Lecture 12 : Thermodynamics of Protein Folding
- Lecture 13 : Protein Structure Methods
- Lecture 14 : Protein Denaturation
- Lecture 15 : Discussion Class
Week 4
- Lecture 16 : Protein Isolation Methods
- Lecture 17 : Protein Purification
- Lecture 18 : Biophysical Methods - I
- Lecture 19 : Biophysical Methods - II
- Lecture 20 : Biophysical Methods III
Week 5
- Lecture 21 : Types of Protein ligand interactions
- Lecture 22 : Kinetics and Thermodynamics of protein-ligand binding
- Lecture 23 : Experimental methods in protein ligand interactions
- Lecture 24 : Protein ligand docking
- Lecture 25 : Discussion class
Week 6
- Lecture 26 : Enzymes I: Classification
- Lecture 27 : Enzymes - II
- Lecture 28 : Enzyme Mechanisms - I
- Lecture 29 : Enzyme Mechanisms - II
- Lecture 30 : Enzyme mechanisms - III
Week 7
- Lecture 31 : Enzyme Kinetics - I
- Lecture 32 : Enzyme Kinetics - II
- Lecture 33 : Enzyme Inhibition - I
- Lecture 34 : Enzyme Inhibition - II
- Lecture 35 : Discussion class
Week 8
- Lecture 36 : Motor Proteins - I
- Lecture 37 : Motor Proteins - II
- Lecture 38 : Metalloproteins - I
- Lecture 39 : Metalloproteins - II
- Lecture 40 : Myoglobin and Hemoglobin
Week 9
- Lecture 41 : Membrane Proteins - I
- Lecture 42 : Membrane proteins - II
- Lecture 43 : Membrane Transport - I
- Lecture 44 : Membrane Transport - II
- Lecture 45 : Electron Transport Chain
Week 10
- Lecture 46 : Protein Carbohydrate Interactions - I
- Lecture 47 : Protein Carbohydrate Interactions - II
- Lecture 48 : Protein Nucleic Acid Interactions - I
- Lecture 49 : Protein Nucleic Acid Interactions - II
- Lecture 50 : Protein Nucleic Acid Interactions - III
Week 11
- Lecture 51 : Protein Protein Interactions - I
- Lecture 52 : Protein Protein Interactions - II
- Lecture 53 : Protein Peptide Interactions
- Lecture 54 : Chaperone proteins
- Lecture 55 : Protein Nanoparticle Interactions
Week 12
Syllabus and materials
At NPTEL, as the course publishes them.
Credits and licence
- Institution
- IIT Kharagpur
- Department
- Chemistry and Biochemistry
- Teacher
- Prof. Swagata Dasgupta
- Level
- Undergraduate
- Language
- English
- Subjects
- Chemistry
- Source
- NPTEL
- Licence
- CC BY-NC-SA, as NPTEL states it. Non-commercial use only. NPTEL's terms
- Attribution
- NPTEL states: "Distributed under Creative Commons Attribution-ShareAlike / CC BY - NC - SA", beside a BY-NC-SA badge.
- Who can watch
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