Catalytic Asymmetric Synthesis

by Tharmalingam Punniyamurthy

Catalytic asymmetric synthesis the synthesis of compound that favors the formation of a specific enantiomer or diastereomer via catalysis synthetic methods. Enantioselective synthesis is a key process in modern chemistry and is particularly important in the field of pharmaceuticals, as the different enantiomers or diastereomers of a molecule often have different biological activity.

Description from LibreTexts.

Publisher
Indian Institute of Technology Guwahati
Subjects
Chemistry, Organic Chemistry
Licence
CC BY-SA, as LibreTexts states it
Who can read
Tweens profiles and older, judged from its title and subjects

Contents

LibreTexts writes equations in TeX, and here they show as TeX; the PDF has them typeset.

  1. Front Matter
  2. TitlePage
  3. InfoPage
  4. Table of Contents
  5. Licensing
  6. 1: Reactions using Chiral Lewis Acids and Brønsted Acid
  7. 1.1: Brønsted Acid-Assisted Lewis Acid (BLA)
  8. 1.2: Lewis Acid-Assisted Lewis Acid (LLA)
  9. 1.3: LBA Catalysts
  10. 1.4: Problems + Reference
  11. 1.5: Chiral Phosphoric Acids (PAs)
  12. 2: Asymmetric Carbon-Carbon Bond Forming Reactions
  13. 2.1: Enantioselective Ene and Cycloaddition Reactions
  14. 2.2: Enantioselective Alkene Metathesis
  15. 2.3: Carbometallation and Carbocyclization Reactions
  16. 2.4: Metal-Catalyzed Asymmetric Conjugate Addition Reactions
  17. 2.5: Allylic Substitution with Carbon Nucleophiles
  18. 2.6: Problems and Reference
  19. 3: Synthesis via C-H Activation
  20. 3.1: Reactions with Metal Carbenoid
  21. 3.2: Reactions With Metal Nitrenoid and Direct C-H Oxidation
  22. 3.3: Problems and Reference
  23. 4: Carbon-Heteroatom Bond-Forming Reactions
  24. 4.1: Allylic Substitution Reactions
  25. 4.2: Aza-Claisen Rearrangement and Related Reactions
  26. 4.3: Hydroamination of Alkenes
  27. 4.4: Hydroalkoxylation of Allenes
  28. 4.5: Oxidation Reactions
  29. 4.6: Aziridination of Alkenes
  30. 4.7: Amination of Carbonyl Compounds
  31. 4.8: Boration of Alkenes
  32. 4.9: Hydrophosphonylation of Imines
  33. 4.10: Problems and Reference
  34. 5: Oxidation Reactions
  35. 5.1: Oxidation of Alcohols
  36. 5.2: Epoxidation of Allylic Alcohols
  37. 5.3: Epoxidation of Unfunctionalized Alkenes
  38. 5.4: Enantioselective Sulfoxidation
  39. 5.5: Baeyer-Villiger Oxidation (BVO)
  40. 5.6: Dihydroxylation, Aminohydroxylation and Aziridination Reactions
  41. 5.7: Problems and Reference
  42. 6: Hydrogenation Reactions
  43. 6.1: Reactions Carbon-Carbon Double Bonds
  44. 6.2: Reactions of Ketones
  45. 6.3: Reactions of Imines (C=N)
  46. 6.4: Problems and Reference
  47. 7: Reactions in Nonconventional Conditions
  48. 7.1: Reactions in Water
  49. 7.2: Reactions in Fluorous Solvents
  50. 7.3: Reactions in Supercritical Fluids (SCFs)
  51. 7.4: Reactions in Ionic Liquids (IL)
  52. 7.5: Microwave-Assisted Reactions
  53. 7.6: Problems and Reference
  54. 8: Asymmetric Hydrosilylation and Related Reactions
  55. 8.1: Hydrosilylation of Alkenes
  56. 8.2: Hydroboration, Hydroalumination and Hydrostannation of Alkenes
  57. 8.3: Problems and Reference
  58. 9: Carbonylation Reactions
  59. 9.1: Hydroformylation Reaction
  60. 9.2: Asymmetric Alkoxycarbonylation and Related Reactions
  61. 9.3: Co- and Terpolymerization of Alkenes with Carbon Monoxide
  62. 9.4: Problems and Reference
  63. 10: Organocatalysis
  64. 10.1: Chiral Proline Based Reactions
  65. 10.2: Alkaloid Based Reactions
  66. 10.3: Thiourea Based Catalysis
  67. 10.4: Problems and Reference
  68. 11: Enzyme-Catalyzed Asymmetric Reactions
  69. 11.1: Acylation of Alcohols and Amines
  70. 11.2: Formation of Carbon-Carbon Bonds
  71. 11.3: Reduction Reactions
  72. 11.4: Enantioselective Oxidations
  73. 11.5: Problems and Reference
  74. 12: Solutions
  75. 12.1: Asymmetric Carbon-Carbon Bond Forming Reactions
  76. 12.2: Asymmetric Hydrosilylation and Related Reactions
  77. 12.3: Carbon-Heteroatom Bond-Forming Reactions
  78. 12.4: Carbonylation Reactions
  79. 12.5: Enzyme-Catalyzed Asymmetric Reactions
  80. 12.6: Hydrogenation Reactions
  81. 12.7: Organocatalysis
  82. 12.8: Oxidation Reactions
  83. 12.9: Reactions in Nonconventional Conditions
  84. 12.10: Reactions Using Chiral Lewis and Brønsted Acids
  85. 12.11: Synthesis via C-H Activation
  86. Back Matter
  87. Index
  88. Index
  89. Glossary
  90. Detailed Licensing