Anaesthetic-Tricaine-Acts-Preferentially-on-Neural-Voltage-Gated-Sodium-Channels-and-Fails-to-Block-pone.0103751.s001

About

Movement of wild type (wt), fixe mutants (chrndsb13/sb13) or fixe sibling (chrndsb13/+ or chrnd+/+) fish in response to EES. Fish were treated with the water control or tricaine at standard or fivefold dose, as indicated before each clip. A pulse train of 0.1 s duration was applied every 5 seconds. Movie is sped up about 2.5-fold for ease of viewing. Note increased movement in response to the first pulse, possibly reflecting the need for channel activation for tricaine to bind to Nav channels. Heartbeat shows all fish are alive. In ‘fixe + 5X tricaine' clip, heartbeat shows fish are alive but fail to respond to stimulation.

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Wikimedia Commons, in Wikimedia Commons

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CC BY 4.0, as the Wikimedia Commons states it.

Rights statement

Creative Commons Attribution 4.0

Credit

Attili S, Hughes S

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