Chaste-An-Open-Source-C++-Library-for-Computational-Physiology-and-Biology-pcbi.1002970.s004

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3D off-lattice simulation confined to a 2D surface: small intestinal crypts and villus. Left: cells are labelled according to their ancestor cell; each crypt gives rise to a monoclonal population, with a multiclonal villus comprised of cells from each crypt. Right: the same simulation, here with cells labelled according to Delta levels (non-dimensionalised); Delta-Notch patterning occurs due to a signalling model inside each cell, which depends on the activity of neighbouring cells, and is thought to lead to differentiation into secretory and absorbative cell types. The simulation runs from to hours.

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Mirams G, Arthurs C, Bernabeu M, Bordas R, Cooper J, Corrias A, Davit Y, Dunn S, Fletcher A, Harvey D, Marsh M, Osborne J, Pathmanathan P, Pitt-Francis J, Southern J, Zemzemi N, Gavaghan D

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