Podcasts · Behind The Knife: The Surgery Podcast

Cancer Vaccines: The Future is Now

· 36 min · Episode 130 · Bonus

Episode Cancer Vaccines: The Future is Now

0:00 35:53

As cancer vaccines move into Phase II and III clinical trials, it is increasingly important for surgeons to understand their role in this evolving landscape. What exactly are these vaccines, how do they work, and what should the surgical community know about their implementation? Join BTK surgical education fellows Kara Button and Michelle LaBella as they sit down with Professor Robert Jones to break down the science of mRNA vaccines, the logistics of tissue procurement, and the future of cancer care.

Hosts:

- Professor Robert Jones: Consultant Liver Surgeon, Liverpool University Hospitals; UK National Institute for Healthcare Research, Co-Lead for the Cancer Vaccine Innovation Pathway, Bowel Cancer UK and Royal College of Surgeons UK Lead for Research into Advanced Bowel Cancer, and UK Chief Investigator for the BNT122-01 trial. https://www.linkedin.com/in/robert-jones-6103722a/

- Kara Button, DO: General Surgery Resident, Maine Medical Center; Behind the Knife Surgical Education Fellow.

- Michelle LaBella, MD: General Surgery Resident; University of North Carolina; Behind the Knife Surgical Education Fellow.

References:

https://clinicaltrials.biontech.com/trials/BNT122-01

Jones RP, Lee LYW, Corrie PG, et al. Individualized cancer vaccines versus surveillance after adjuvant chemotherapy for surgically resected high-risk stage 2 and stage 3 colorectal cancer: protocol for a randomized trial. BJS. 2023;110(12):1883-1884. doi:10.1093/bjs/znad332 https://pubmed.ncbi.nlm.nih.gov/37856683/

Tie J, Wang Y, Loree JM, et al. Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial. Nat Med. 2025;31(12):4291-4300. doi:10.1038/s41591-025-04030-w https://pubmed.ncbi.nlm.nih.gov/41115959/

Rojas LA, Sethna Z, Soares KC, et al. Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. Nature. 2023;618(7963):144-150. doi:10.1038/s41586-023-06063-y https://pubmed.ncbi.nlm.nih.gov/37165196/

https://www.cancer.ox.ac.uk/research/lynchvax#:~:text=The%20LynchVax%20program%2C%20funded%20by,individuals%20with%20this%20genetic%20condition

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