Podcasts · Technology · Science

Latent Space: The AI Engineer Podcast

Latent.Space

287 episodes

The main Latent Space podcast: AI engineering, Forward Deployed Engineering, AI for science, and ⚡ Lightning episodes. Other feeds: Engineering and FDE: https://podcast.latent.space/eng.xml; Science: https://podcast.latent.space/science.xml; Misc (Lightning and other shows): https://podcast.latent.space/misc.xml; Firehose (all available shows): https://podcast.latent.space/firehose.xml. Feed directory: https://latent.space/pods

Episodes page 1 of 6

  1. How Anthropic ships the #1 LLM in the World safely: Separating the Brain from the Hands

    · 1 h 47 min

    Katelyn Lesse and Angela Jiang join Latent Space to explain the engineering behind the Claude Platform: launching Opus 5.5, separating the model’s “brain” from the agent’s “hands,” scaling APIs, and building reliable…

  2. Why Agents Love Supabase

    · 1 h 17 min

    AI agents are creating more software—and that changes what a backend needs to do. Supabase co-founders Paul Copplestone and Ant Wilson join swyx to discuss running long-lived workloads alongside the database, making…

  3. ⚡ An Eval for AI Scientists That Knows the Answer Key - Ian Quigley, Leash Bio

    · 17 min

    Watch the full show on YouTube: https://www.youtube.com/watch?v=vhPCo-8K78U Full show notes and links

  4. Why AI Compute Comes in Rectangles — Erik Bernhardsson, Modal CEO

    · 1 h 26 min

    Warm welcome to Basil Chatha, our newest cohost from the Forward Deployed side of the AI Engineering world! We’ll be ramping up a new show with him and couldn’t pass up an interview with Modal’s CEO Eric on the…

  5. The Recommendation Engine for Commodity Traders — Anekha Sokhal, Moshi

    · 27 min

    Anekha Sokhal, CEO of Moshi, joins swyx to discuss building a recommendation engine for commodity traders, turning market data into useful signals, and designing AI that fits users’ workflows. Watch: YouTube · Moshi ·…

  6. AI for the Fortune 2000: How Tenex Builds an AI-Native SDLC — Alex Lieberman & CJ Hess

    · 44 min

    Alex Lieberman and CJ Hess join swyx at AI Engineer New York to discuss Tenex’s approach to AI-native engineering, paying for outcomes, MetaHarness, enterprise AI adoption and rebuilding SaaS. Show notes: Tenex:…

  7. The Programmable Data Center — Evan Conrad, SF Compute

    · 37 min

    This was recorded on the sidelines of the new Compute Trading track at AIE NYC. Catch us next at AIE CODE, our last flagship for the top agentic engineers in the world. In the early days of cloud, former guest Martin…

  8. 🔬 Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio

    · 1 h 50 min

    A few years ago I stumbled upon Leash Bio’s Substack, and was hooked. Be it their Kaggle competition that showed that no, we really haven’t solved protein-ligand binding, or their crazy discovery that knowing a…

  9. Dyna-2: General Purpose Physical Agents with Hour-Long Autonomy — Jason Ma, Dyna Robotics

    · 1 h 12 min

    Watch along AIE NYC and join us at AIE CODE in SF next month! This episode includes a live demo of the Taku robot that is best enjoyed on YouTube. Last month, Dyna made waves by announcing Dyna-2, a world-action model…

  10. 🔬 Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub

    · 32 min

    From the Bitter Lesson of AI scaling to the unsolved mysteries of protein folding, Google DeepMind’s Pushmeet Kohli and Biohub’s Sal Candido are rethinking what it takes to build AI that truly understands biology. In…

  11. 🔬 Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk

    · 1 h 24 min

    It’s hard to believe that Periodic was only launched last September: One year later, it is considered one of the pre-eminent AI scientist labs, with dizzying talent density and astonishing progress in the autonomous…

  12. ⚡️ Which GPU Clouds Are Actually Good? | ClusterMAX 3.0

    · 58 min

    Watch the full show on YouTube: https://www.youtube.com/watch?v=MWX36ZYnsm0 Full show notes and links

  13. Academia is for Ambition — Alex Zhang, MIT

    · 1 h 41 min

    Last call for regular tickets for AI Engineer NYC! As an exclusive for Latent Space subscribers, the first 30 of you can take a 30% off code if it helps - for new tickets only, no refunds! See you in 2 weeks! While we…

  14. Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week

    · 39 min

    Three months ago Dwarkesh, who has been posting incredible blogs and episodes about RL, posted a framing question for his video essay on RLVR which upset a lot of Computer Use folks: We are no strangers to learning in…

  15. Claude Code’s Next Era — Thariq Shihipar, Anthropic

    · 1 h 32 min

    We are excited to have Anthropic share their latest AI x Finance work at AI Engineer New York ( https://ai.engineer/nyc/2026 ), coming up in 2 weeks! In case you’ve been under a rock, here’s a non-exhaustive list of…

  16. OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha

    · 1 h 21 min

    From the earliest days of open-weight models to becoming the neutral routing layer for more than 10 million developers, OpenRouter is one of the clearest bets that the future of AI will be multi-model. In this episode,…

  17. Runway’s WorldPrompt and the Engineering of Real-Time Worlds

    · 1 h 36 min

    Earlier this month, world model company Runway introduced GWM Worlds 2, a research preview that “turns high-fidelity video and audio generation into real-time interactive simulation.” Runway calls this an…

  18. 🔬 Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)

    · 1 h 32 min

    The OpenAI → Hugging Face attack has people asking “what else do we need to worry about?” and Anthropic’s filters flag two things: cyber-security and biology. The natural question is: what about bio-security, then?…

  19. 🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science

    · 2 h 01 min

    How often do you get to talk to a guest who has both an Academy Award and who invented textbook machine learning algorithms? John Platt has an Oscar, two textbook algorithms, two named asteroids, and an Erdos-Bacon…

  20. Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI

    · 2 h 21 min

    Tickets for AIE NYC now open, and apply for the invite-only AIE CODE. Join us! We have an unusual relationship with today’s guest: for years since coauthoring the InstructGPT paper, Diogo Almeida had been saying that…

  21. ⚡️ A Worm With 302 Neurons Inspired Their Architecture — Ramin Hasani, Liquid AI

    · 1 h 10 min

    Watch the full show on YouTube: https://www.youtube.com/watch?v=V_9TCu_21SE Full show notes and links

  22. Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC

    · 1 h 26 min

    AIUC first got our attention with the NFDG backing, and have just announced a $40M series A today, with the most impressive industry advisor list we may have ever seen for an early startup behind AIUC-1, their agent…

  23. Humanity’s Last Invention — Richard Socher of Recursive

    · 1 h 32 min

    At 1:09:00 we talk about the rise of AI x Finance, and AIE NYC is one month away - our hotel block is 97% sold out, get tix & travel ASAP - we will announce speakers from Bridgewater, Ramp, Coatue, Mastercard,…

  24. 🔬 “We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing

    · 1 h 24 min

    A few years ago, Caltech Prof. and co-founder of Accelerated Understanding, Anima Anandkumar set out to develop the first open-source weather model with AI. Talking to experts in the field, she was met with skepticism.…

  25. ⏭️ Forward Deployed: Voice AI on what works in 2026

    · 37 min

    Watch the full show on YouTube: https://www.youtube.com/watch?v=MwNvowwcZOo Full show notes and links

  26. Simulation: the new Scaling Law — Joon Sung Park, Simile AI

    · 1 h 10 min

    When we first dicsussed the Summer of Simulative AI in 2024 we knew it would be a brief summer, but it has recently come back with a vengeance with SimGym in April and now Simile AI’s $2B Series B, backed by GreenOaks…

  27. ⚡️ Exo: Harnesses should see their own code and logs — Alex Krentsel, UC Berekeley / Google Research

    · 47 min

    Watch the full show on YouTube: https://www.youtube.com/watch?v=5lFD-34dhqE Full show notes and links

  28. 🔬 The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery

    · 1 h 35 min

    This January, four big AI × Pharma tools deals were announced at the huge JPM Pharma conference that takes over San Francisco every year. OpenAI-backed Chai Discovery (now worth $4B) was somehow at the heart despite…

  29. The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten

    · 1 h 41 min

    Watch the full episode on YouTube: We first covered Baseten last year when DeepSeek mania was at peak hype. Now they have raised a monster $13B round and become one of the new cohort of AI Infra decacorns that are…

  30. Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI

    · 1 h 09 min

    There are roughly 100x more people who use code than who can write code. As code that “just works” becomes easier to generate, this group may be the biggest prize of all — if you can get the agentic interface right. A…

  31. Inside the Model Factory — Eiso Kant, Poolside AI

    · 1 h 55 min

    In recent months, the open vs closed, and US vs China discussions on model ownership and sovereign/local AI have heated up to a fever pitch. So it is very very good news that Poolside AI are finally emerging with new…

  32. 🔬 Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)

    · 1 h 30 min

    Bet on information If test loss flatlines after 1.5B parameters while training loss continues to drop as you scale, that tells you that your model is limited by the amount of information in your data. Training on a…

  33. 🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences

    · 1 h 41 min

    Imagine a dark warehouse. Racks and racks of devices with wires, tubes, and electronics sticking out. The next AI data center? No. This is Lila Sciences ‘ dream for the future of science. A dark warehouse full of…

  34. ⚡️ Podcast Crossover: AIE, AGI, frontier lab strategy with @matthew_berman and @swyxtv

    · 28 min

    Watch the full show on YouTube: https://www.youtube.com/watch?v=bIOCKXcxloQ Full show notes and links

  35. Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO

    · 58 min

    We’ve been running a bit of an Agent Cloud series surveying all the top inference/compute/cloud providers, from Databricks to Daytona to Railway and, even further back, E2B, but we’re excited to conclude this series…

  36. 🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI

    · 1 h 49 min

    This episode has a fun personal twist: There’s a counterfactual world where I was employee #1 at Genesis Molecular AI, the company behind today’s episode. A certain introduction happened a few weeks too late and I had…

  37. ⚡️ The Blueprint for Autonomous Work Agents | Gavriel Cohen, NanoClaw

    · 23 min

    Watch the full show on YouTube: https://www.youtube.com/watch?v=hLUGXO5DSpo Full show notes and links

  38. Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks

    · 1 h 09 min

    We’re excited to have Databricks join us at AIEWF, among hundreds of the top companies in the AI Engineer ecosystem. LS subscribers can use their discount to get past the late bird pricing and access over $50k in…

  39. Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan

    · 1 h 06 min

    AI Engineer World’s Fair regular bird tix will sell out ~today! Join us next week ahead of the Late Bird price hike and get >$40,000 in sponsor credits for attending! Thanks to the US Government issuing an export…

  40. ⚡️ Every product of the future will be a living system — Ronak Malde, Trajectory.ai

    · 34 min

    Watch the full show on YouTube: https://www.youtube.com/watch?v=DcvgPEApHT8 Full show notes and links

  41. The Professor of Outputmaxxing — Anjney Midha, AMP

    · 59 min

    Last 4 days before regular tickets sell out at AI Engineer World’s Fair - this is the single biggest gathering of AI Engineers, Founders, Leaders, and Researchers in the world. Attendees get >$5000 worth of sponsor…

  42. 🔬 The Self-Driving Lab — Joseph Krause, Radical AI

    · 1 h 17 min

    On the Science pod, we’ve been covering a lot of the ground on how AI is revolutionizing STEM, but one of our favorite off the record topics since our launch is which field is harder to accelerate: math, bio, or…

  43. ⚡️ Making DeepSeek v4 outperform Opus 4.7 with Taste — @AhmadAwais , CommandCode.ai

    · 41 min

    Watch the full show on YouTube: https://www.youtube.com/watch?v=-rIAVuaRjOg Full show notes and links

  44. Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs

    · 1 h 16 min

    The new AIEWF website is live! Get your tickets booked ASAP as they -will- sell out. Take the AI Engineering Survey and get >$2k in credits and free AIE WF tickets! Most industry benchmarks compress intelligence and…

  45. 🔬 Scaling Past Informal AI - Carina Hong, Axiom Math

    · 1 h 33 min

    In 2025, seven-month-old startup Axiom solved all 12 of the problems Putnam exam (scoring 8/12 in the time limit) a prestigious undergraduate math exam. The 12/12 score is better than the top undergraduates (110/120)…

  46. ⚡️ Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build

    · 39 min

    We’ve informally heard that Satya is a listener to LS for a couple years now, but it was still absolutely surreal to meet him and do a live pod at Build, together with our friends at No Priors, the leading VC AI…

  47. GitHub's plan for Agents — Kyle Daigle, GitHub

    · 1 h 23 min

    I’m excited to work with Microsoft once again as the presenting sponsors of the AI Engineer World’s Fair! We’ll streaming live from MS Build today for a special crossover pod with our friends at No Priors and the one…

  48. Why Video Agent models are next — Ethan He, xAI Grok Imagine

    · 1 h 43 min

    We’re announcing AIEWF speakers this week! Take the AI Engineering Survey! Today’s guest Ethan first joined us for the LS Paper Club as the lead on NVIDIA Cosmos World Model, but then joined xAI and built Grok Imagine…

  49. The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray

    · 1 h 08 min

    The new AIEWF website is live! CFPs close in 2 days and we will run our first New Engineer Orientation this weekend, get your tickets booked ASAP as they -will- sell out. Take the AI Engineering Survey and get >$2k in…

  50. 🔬 ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub

    · 1 h 10 min

    Editor’s note: In our first BioHub pod with Priscilla and Mark they discussed their acquisition of EvoScale, led by Alex Rives, who is now Head of Science at BioHub. With ESM-1 they trained language models on millions…

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