Podcasts · From Our Neurons to Yours

After Ozempic: the revolution in peptide science | Jonathan Long

· 50 min · S9 E15

Episode After Ozempic: the revolution in peptide science | Jonathan Long

0:00 49:54

Health influencers and scientists have both gone crazy for peptides. The peptide health craze stems from a lot of online hype — centered on gray-market compounds that haven't been rigorously tested in humans and aren't regulated for safety or purity. But among scientists, there is a genuine "revolution" underway — spurred by technological developments revealing an order of magnitude more peptides in our bodies than we ever realized, and by the unexpected and unparalleled success of GLP-1 drugs like Ozempic. To learn more about what’s driving this excitement – and how much of the peptide hype is really worth your attention – we spoke with Stanford biochemist Jonathan Long, an associate professor of pathology at Stanford Medicine, an affiliate of the Wu Tsai Neurosciences Institute, and an Institute Scholar of Stanford Sarafan ChEM-H. Editor's Note: After we went to press, Colorado biotech Enveda announced promising but early Phase 1 safety results for ENV-308, an oral drug engineered to mimic Lac-Phe — the "exercise in a pill" molecule Long's lab first characterized in 2022. The trial didn't test actual weight-loss or fitness effects, so the real thing isn't here yet — but Long, a scientific advisor to Enveda, calls it "an extremely exciting potential scientific breakthrough." Read more

Learn more

• Long Lab of Chemical Physiology • An ‘Exercise Pill’ Just Cleared Its First Human Test (Gizmodo, 2026) • A pill that mimics exercise? Early results on drug designed to maintain both weight loss and muscle mass (STAT, 2026) • Peptides are everywhere. Here’s what you need to know. (MIT Technology Review, 2026) • Influencers are promoting peptides for better health. What does the science say? (NPR, 2026) • What doctors want patients to know about injectable peptides (American Medical Association, 2026) • Why Are People Injecting Themselves with Peptides? (The New Yorker, 2026) • Peptides are buzzing: But what does the science say? (Stanford Medicine, 2026) • Study of pythons’ extreme diet reveals new hunger-curbing molecule (Knight Initiative for Brain Resilience, 2026) • Unlocking the secrets of ketosis (Knight Initiative for Brain Resilience, 2024) • Weight loss caused by common diabetes drug tied to "anti-hunger" molecule in study (Stanford Medicine, 2024) • Q&A: Unlocking the secrets of taurine in obesity control (Knight Initiative for Brain Resilience, 2024) • Exercise and the brain (From Our Neurons to Yours, 2023) • Lac-Phe mediates the effects metformin on food intake and body weight (Nature Metabolism, 2024)

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