TdC 347: Cirrose descompensada - quando é ACLF?
· 28 min · S7 E347
Episode TdC 347: Cirrose descompensada - quando é ACLF?
Nordman Wall e Flávio Barbieri convidam Carolina Mendes para discutir o conceito e manejo da insuficiência hepática crônica agudizada, do inglês Acute-on-Chronic Liver Failure (ACLF), quadro clínico que vai além da cirrose hepática descompensada, somando disfunções orgânicas e maior mortalidade.
Referências:
• Arroyo V, Moreau R, Jalan R. Acute-on-chronic liver failure. N Engl J Med. 2020;382(22):2137-45. • Rashed E, Soldera J. CLIF-SOFA and CLIF-C scores for the prognostication of acute-on-chronic liver failure and acute decompensation of cirrhosis: a systematic review. World J Hepatol. 2022;14(12):2025-43. • European Association for the Study of the Liver. EASL Clinical Practice Guidelines on acute-on-chronic liver failure. J Hepatol. 2023;79(2):461-91. • Karvellas CJ, Bajaj JS, Kamath PS, et al. AASLD Practice Guidance on acute-on-chronic liver failure and the management of critically ill patients with cirrhosis. Hepatology. 2024;79(6):1463-502. • Artzner T, Fernandez J, Jalan R. Liver transplantation for patients with severe acute on chronic liver failure: it is time to change paradigms. Intensive Care Med. 2023;49(6):689-91. • Palliative care in the patient with acute-on-chronic liver failure. Clin Liver Dis (Hoboken). 2022;19(5):198-202. • Mezzano G, Juanola A, Cardenas A, et al. Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis. Gut. 2022;71(1):148-55. • Nagel M, Westphal R, Hilscher M, et al. Validation of the CLIF-C OF score and CLIF-C ACLF score to predict transplant-free survival in patients with liver cirrhosis and concomitant need for intensive care unit treatment. Medicina (Kaunas). 2023;59(5):866. • Hareesh GJ, Ramadoss R. Clinical profile, short-term prognostic accuracies of CLIF-C ACLF score and serial CLIF-C OF scores in acute-on-chronic liver failure patients: a prospective observational study. Indian J Crit Care Med. 2024;28(2):126-33. • Belli LS, Duvoux C, Artzner T, et al. Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe: results of the ELITA/EF-CLIF collaborative study (ECLIS). J Hepatol. 2021;75(3):610-22.
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