Podcasts · Psychiatry & Psychotherapy Podcast
Psychiatrist Effect in First-Episode Psychosis: HAMLETT Study, Antipsychotic Tapering, Dopamine Supersensitivity & Sex Differences with Franciska de Beer
· 1 h 12 min
Episode Psychiatrist Effect in First-Episode Psychosis: HAMLETT Study, Antipsychotic Tapering, Dopamine Supersensitivity & Sex Differences with Franciska de Beer
In this episode, Dr. Puder sits down with Franciska de Beer, MSc, first author of landmark HAMLETT-OPHELIA Consortium papers in JAMA Psychiatry, World Psychiatry, and Psychological Medicine. They dive deep into the psychiatrist effect in first-episode psychosis, revealing that individual psychiatrists explain approximately 10% of variance in positive symptom improvement and daily functioning, even after controlling for medication dose. The conversation explores groundbreaking HAMLETT findings on early antipsychotic tapering versus maintenance, dopamine supersensitivity after high-affinity D2 blockers, sex differences in treatment outcomes and clozapine levels during menopause, and why shared decision-making and reflective functioning matter more than ever in psychosis care.
By listening to this episode, you can earn 1.25 Psychiatry CME Credits.
Link to blog
Link to YouTube video
Links in the notes 3
- https://www.psychiatrypodcast.com/cme-program
- https://www.psychiatrypodcast.com/psychiatry-psychotherapy-podcast/episode-263-psychiatrist-effect-in-first-episode-psychosis-hamlett-study-antipsychotic-tapering-dopamine-supersensitivity-amp-sex-differences-with-franciska-de-beer
- https://youtu.be/B_QLIIglJ9k
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