Podcasts · The Curbsiders Internal Medicine Podcast

#494 C. diff, Diarrhea, the Microbiome, and New Therapies with Dr. Cynthia Sears. Live from Johns Hopkins Grand Rounds

· 53 min

Episode #494 C. diff, Diarrhea, the Microbiome, and New Therapies with Dr. Cynthia Sears. Live from Johns Hopkins Grand Rounds

0:00 53:25

Dominate C. diff! Learn to distinguish colonization from infection, select first-line therapies, and counsel patients on recurrence prevention and microbiome recovery. We’re joined by IDSA past president and expert on foodborne and intestinal infections, Dr. Cindy Sears (Johns Hopkins University) for a comprehensive update on Clostridioides difficile (C. diff, Cdiff, CDAD, CDI). Claim CME for this episode at curbsiders.vcuhealth.org! Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME Show Segments

• 00:00 Intro • 03:00 Guest bio and hobby • 04:25 Case of Charles Fleur Fontaine • 06:00 Risk factors and epidemiology • 08:00 Antibiotic hierarchy of risk • 10:00 Diagnosis, testing strategies • 14:00 Defining severity • 17:30 Treatment options • 20:00 Microbiome recovery strategies • 24:00 Probiotics and postbiotics • 27:00 Infection control counseling • 30:00 C. diff and colon cancer • 32:00 Recurrent C. diff strategies • 35:00 Why some FMT and bezlotoxumab were discontinued • 38:00 Microbiota replacement therapies • 43:00 Prophylaxis strategies • 45:00 Future therapies and ongoing research • 47:00 Audience Q&A • 52:00 Outro

Credits

• Written and Produced by: Matthew Watto, MD, FACP • Cover Art and Infographic by: • Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP • Reviewer: Sai S Achi MD,MBA,FACP • Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP • Technical Production: PodPaste • Guest: Cynthia Sears MD

Disclosures Dr. Sears reports no relevant financial disclosures. Dr. Williams financial relationships disclosed include a Merck grant or research support. This relationship has not ended. Sponsor: Mint Mobile This year, skip breaking a sweat AND breaking the bank. Get this new customer offer and your 3-month Unlimited wireless plan for just 15 bucks a month at mintmobile.com/CURB Sponsor: Panacea Financial Let Panacea Financial take the financial stress off your plate,so you can get back to doing what matters most. Visit panaceafinancial.com Sponsor: FIGS Get15% off your first order at wearfigs.com with the code FIGSRX

Links in the notes 7

The episode on the publisher’s site

Shows are listed from Apple Podcasts' charts and directory, and Podcast Index where it is used. Every show and episode belongs to its publisher and plays from the publisher's own feed; this site hosts none of them. Explicit shows are for adult profiles only, and children’s profiles hear only children’s shows. More about this list.